A5067408418- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- bioluminescence and chemiluminescence research
- Nanoplatforms for cancer theranostics
- Photosynthetic Processes and Mechanisms
- Light effects on plants
- Water Quality Monitoring and Analysis
- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Photochemistry and Electron Transfer Studies
- Porphyrin Metabolism and Disorders
- Free Radicals and Antioxidants
- Skin Protection and Aging
- Algal biology and biofuel production
- Dye analysis and toxicity
- Photoacoustic and Ultrasonic Imaging
- Insect and Pesticide Research
- Various Chemistry Research Topics
- Neonatal Health and Biochemistry
- Tendon Structure and Treatment
- Electrochemical Analysis and Applications
- Biocrusts and Microbial Ecology
- Molecular Sensors and Ion Detection
- Retinal Diseases and Treatments
- Environmental Toxicology and Ecotoxicology
Philadelphia College of Osteopathic Medicine
2020-2023
University of Utah
1993-2007
Czech Academy of Sciences, Institute of Macromolecular Chemistry
1997
University of Padua
1978
University of Minnesota
1962-1969
University of Utah Hospital
1969
United States Department of Veterans Affairs
1968
California Institute of Technology
1944
The load-strain and stress-relaxation behavior of wet rat tail tendon has been examined with respect to the parameters strain, rate straining, temperature. It is found that this mechanical reproducible after resting for a few minutes each extension so long as strain does not exceed about 4 per cent. If exceeded, becomes progressively easier extend but its length still returns original value extension. Extensions over 35 cent can be reached in way. Temperature no effect upon range 0-37...
Research in Photosynthesis Get access Photosynthesis. Edited by Gaffron H. Brown A. French C. S. Livingston R. Rabinowich E. I. Strehler B. L. Tolbert N. E.. 524 pp. Interscience Publishers, Inc., 250 Fifth Ave., New York 1, Y. ( 1957) $12.00 John D. Spikes University of Utah. Search for other works this author on: Oxford Academic Google Scholar AIBS Bulletin, Volume 8, Issue 3, June 1958, Page 30, https://doi.org/10.2307/1292394 Published: 01 1958
Abstract— Porphyrins used as sensitizers for the photodynamic therapy (PDT) of tumors are progressively destroyed (photobleached) during illumination. If porphyrin bleaches too rapidly, tumor destruction will not be complete. However, with appropriate sensitizer dosages and bleaching rates, irreversible injury to normal tissues surrounding tumor, which retain less sensitizer, may significantly decreased. This paper surveys quantum yields kinetics photobleaching four porphyrins:...
Abstract The efficiency of several porphyrins at 10 μ M and 83 as sensitizers the photooxidation 0.1 m tryptophan histidine via a singlet oxygen‐mechanism was studied in pH 7.4‐buffered aqueous solutions dispersions Triton X‐100 micelles. were either solubilized bulk medium or associated with micellar phase, whereas amino acids always located phase. With those porphyrins, such uroporphyrin I, meso‐tetra (4‐sulfonatophenyl)porphine, meso‐tetra(4‐carboxyphenyl)porphine...
As part of a study on the role Tyr residues in photosensitized intermolecular crosslinking proteins, we have surveyed kinetics rose bengal- and flavin mononucleotide (FMN)-sensitized photooxidation water-soluble N-(2-hydroxypropyl)methacrylamide copolymer with attached 6-carbon side chains terminating tyrosinamide groups (thus -OH group is free, but both amino carboxyl are blocked, simulating situation nonterminal protein). The photodynamic can result only from formation Tyr-Tyr (dityrosine)...
Three water soluble copolymers based on N-(2-hydroxypropyl)methacrylamide were prepared. Copolymer I contains adriamycin, a chemotherapeutic agent, attached via enzymatically degradable oligopeptide (glycylphenylalanylleucylglycine; G-F-L-G) side chains. The other two contained the photosensitizer, meso-chlorin e6 monoethylene diamine disodium salt (Mce6). In II, chlorin is G-F-L-G sequence, and it was bound by nondegradable glycyl spacer in III. Initially, characterized separately vitro...
Abstract— This paper describes an experimental study of the photo properties triplet (T,) states hematoporphyrin (HP) and coproporphyrin (CP), particularly in relation to their medium dependence reactivity towards oxygen. Triplet‐triplet absorption spectra HP CP have been determined aqueous buffer at pH = 7.4 water‐methanol water‐formamide mixtures. The corrected for ground state contributions show major peaks near 400 nm lesser 500 nm. Extinction coefficient measurements made dependences on...
Abstract— A kinetic investigation was performed on the photooxidation of methionine sensitized by various porphyrins at different oxygen concentrations. The rate found to be strongly dependent nature sensitizer. In case hematoporphyrin, chelation Mg 2+ and Zn especially Cu Fe caused a significant decrease photosensitizing efficiency. Fluorescence and/or flash photolysis studies showed that such is ascribed an enhancement non‐radiative decay first excited singlet state as well reduction...
Summary If trypsin is illuminated with visible light in the presence of an appropriate sensitizing dye and oxygen, a loss enzymatic activity observed. This phenomenon called photodynamic inactivation. Quantum requirement studies were made on this system using illumination provided by projector or high‐pressure mercury arc equipped multilayer interference filters. Light energy absorbed was measured vacuum thermocouplegalvanometer combination which calibrated standard lamp. Aliquots taken at...