Abstract Aims This study aims to assess the prevalence of relative apical sparing pattern (RASP) in patients with severe symptomatic aortic stenosis (AS), referred for surgical valve replacement (AVR), evaluate its significance, possible relation amyloid deposition, and persistence after surgery. Methods results Prospective 150 consecutive [age 73 (interquartile range: 68–77), 51% women], AS AVR. All underwent cardiac magnetic resonance (CMR) before RASP was defined by [average longitudinal...

Abstract Background Sarcoidosis is a rare inflammatory disease characterized by the presence of myocardial noncaseating granulomas. Heart failure, conduction abnormalities and/or life-threatening arrhythmias are main manifestations cardiac sarcoidosis (CS). Cardiac magnetic resonance (CMR) plays major role in diagnostic suspicion involvement sarcoidosis. However, late gadolinium enhancement (LGE) patterns non-specific, and one should consider alternative or additional aetiologies for...

Myocardial fibrosis (MF) takes part in left ventricular (LV) remodelling patients with aortic stenosis (AS), driving the transition from hypertrophy to heart failure. The structural changes that occur this are not fully enlightened. aim of study was describe histopathological at endomyocardial biopsy (EMB) severe AS referred surgical valve replacement (AVR) and correlate them LV tissue characterization pre-operative cardiac magnetic resonance (CMR).

Abstract Left ventricular (LV) hypertrophy is a common finding in patients with severe aortic stenosis (AS). Cardiac magnetic resonance (CMR) the gold-standard technique to evaluate LV remodeling. Our aim was assess prevalence and describe patterns of adaptation AS before after surgical valve replacement (AVR). Prospective study 130 consecutive (71y [IQR 68–77y], 48% men) AS, referred for AVR. Patterns remodeling were assessed by CMR. Besides normal structure, four other considered:...

<b><i>Background:</i></b> In patients with heart failure (HF) and reduced ejection fraction (HFrEF) or without type 2 diabetes mellitus, the sodium-glucose cotransporter inhibitor (SGLT2i) dapagliflozin was recently shown to reduce risk of worsening HF death from cardiovascular causes in (DAPA-HF) trial. Our goal investigate how many a real-world setting would be eligible for according DAPA-HF enrolment criteria. <b><i>Methods:</i></b> This is...

Takotsubo syndrome (TTS) mimics acute coronary syndromes but can lead to serious cardiac complications, emphasizing the need for improved understanding and management.

Acute decompensated heart failure (ADHF) admissions are frequently complicated by different patterns of serum creatinine (SCr) elevation. We aimed to assess the prognostic impact worsening renal function (WRF) based on timing its occurrence.This was a retrospective cohort patients admitted for ADHF. Standard WRF defined as an increase in SCr ≥0.3 mg/dl during hospitalization. classified early (within 48 hours admission) or late (>48 hours). kidney injury (AKI) at admission rise from...

Hypertrophic cardiomyopathy is an inherited cardiac disease and a major cause of heart failure sudden death. Although it was first described more than 50 years ago, sarcomeric hypertrophic still lacks disease-specific treatment: the drugs routinely used alleviate symptoms but do not prevent or revert phenotype. With recent advances in knowledge genetics pathophysiology cardiomyopathy, new genetic pharmacological approaches have recently been identified studied that, by influencing different...

Heart transplant (HT) remains the gold standard treatment for selected patients with advanced heart failure (HF).1 However, increasing number of HT candidates and limited donor supply has led to extended waiting list times.2 Thus, may be at risk progressive clinical deterioration delisting due development contraindication(s).3 Left ventricular assist devices (LVADs) improve survival, reduce mortality, have significantly changed patient prioritization criteria in several countries.3-6 Yet,...

Exercise oscillatory ventilation (EOV) is a strong prognostic marker in patients with heart failure (HF) and left ventricular (LV) dysfunction. This phenomenon can be explained through single quantitative measurement of ventilatory instability, the loop gain. Therefore, we aimed to evaluate whether gain could better tool than subjective EOV evaluation identify HF higher risk major cardiovascular complications. was single-center retrospective study that included ejection fraction (LVEF) ≤ 50%...

Abstract Background Constrictive pericarditis remains a problematic diagnosis and thorough investigation is critical. Among possible aetiologies, immunoglobulin-G4 (IgG4)-related pericardial disease an unusual cause of constriction. We report challenging diagnostic case constriction due to IgG4-related disease. Case presentation A 68-year old male with history inferior myocardial infarction right ventricle (RV) involvement was thrice-hospitalized marked ascites peripheral oedema. Systemic...

Wunderlich syndrome is a rare and possibly life-threatening haemorrhagic presenting as spontaneous nontraumatic renal rupture with subcapsular perinephric haemorrhage. Apixaban, direct oral anticoagulant recommended in patients atrial fibrillation, has previously been associated atraumatic solid organ but, to date, no case of apixaban-related reported. We report apixaban while addressing the difficulties face by clinicians when managing anticoagulation bleeding patients.

Abstract Introduction Mavacamten is a newly approved drug for obstructive hypertrophic cardiomyopathy (oHCM) and currently being studied in non-obstructive HCM (nHCM). Our goal was to evaluate how often patients with oHCM nHCM real-world cohort would be eligible the main mavacamten trials: EXPLORER-HCM, VALOR-HCM MAVERICK-HCM. Methods Single-centre retrospective study enrolling consecutive confirmed HCM, as per 2023 ESC Guidelines, at least yearly follow-up our center, from 2017-2023. Key...

Abstract Introduction Tafamidis 61mg was shown to be the first treatment reduce cardiovascular hospitalizations and improve survival in patients with Transthyretin Amyloid Cardiomyopathy (ATTR-CM). Real-world data on efficacy of transthyretin (TTR) stabilizers Heart Failure (HF) due ATTR-CM is scarce. Purpose We aimed assess use tafamidis our center, that features a dedicated Clinic. Methods conducted an all-comers single-centre prospective study consecutive symptomatic HF followed up...

Abstract Background The estimation of pretest probability (PTP) is a key step when evaluating patients with suspected coronary artery disease (CAD). Current European guidelines recommend using an algorithm based on age, sex, and symptom typicality. However, many cardiologists do not regularly use this method, relying instead overall clinical impression. aim study was to compare algorithmic prediction obstructive CAD in set symptomatic chronic syndrome (CCS). Methods In survey study, 10 from...

Abstract Introduction Cardiac amyloidosis due to transthyretin deposition (ATTR-CM) is often underdiagnosed. An increased left ventricular wall thickness (LVWT) should raise the suspicion for ATTR-CM, but it a very frequent and non-specific finding. In order improve diagnostic certainty, an echocardiographic score (Increased Wall Thickness [IWT] score) was recently proposed. The aim of our study assess performance IWT in independent population with LVWT. Methods We conducted retrospective...

Abstract Background myocardial adaptation to severe aortic stenosis (AS) is a complex process that involves fibrosis (MF) beyond cardiomyocyte hypertrophy. Perfusion impairment believed be involved in remodeling chronic pressure overload. Aim describe morphological and ultrastructural changes at EMB, possibly reflecting subendocardial ischemia, group of patients with AS referred surgical valve replacement (AVR), no previous history ischemic cardiomyopathy. Methods one-hundred-fifty-eight (73...

Abstract Background Myocardial fibrosis (MF) takes part in left ventricular (LV) remodeling patients with aortic stenosis (AS), driving the transition from hypertrophy to heart failure. The structural events that occur this are not fully enlightened. Aim To describe histopathology changes at endomyocardial biopsy (EMB) severe AS referred surgical valve replacement (AVR); correlate them LV tissue characterization pre-operative cardiac magnetic resonance (CMR). Methods One-hundred-fifty-eight...

Abstract Introduction Surgical aortic valve replacement (SAVR) is the treatment of choice for young patients with severe stenosis (AS) and low surgical risk. Left ventricular (LV) reverse remodeling (RR) after surgery expected to occur. However, this not always case following afterload relief, may impact prognosis. We aimed assess prognostic effect distinct definitions LV RR SAVR in long-term outcome AS. Methods Single-centre prospective study including referred due symptomatic AS, no...

Abstract Background Left ventricular (LV) remodeling in patients with severe aortic stenosis (AS) is believed to be reversible after pressure overload relieve, as provided by both surgical (SAVR) or transcatheter valve replacement. However, LV reverse (RR) far from uniform AS and the same clinical indication for treatment. Aim To determine prevalence imaging predictors of RR SAVR symptomatic AS. Methods single-center, prospective cohort study enrolling 119 (age 71±8y, 49% male; mean...

Abstract Introduction One crucial element in cardiopulmonary exercise testing (CPET) involves identifying the first and second ventilatory thresholds (VT), VT1 VT2, which hold known prognostic implications. If individual can sustain considerably beyond a third breakpoint (VT3 – Figure A) may emerge, coinciding with heightened hyperventilation to counter metabolic acidosis. Historically, this point has been mainly described among athletes its meaning is still not entirely clear. We aimed...

Abstract Background and Objectives One of the strongest prognostic parameters obtained during Cardiopulmonary exercise testing (CPET) in patients with heart failure (HF) is peak oxygen uptake (pVO2), as a standalone or percentage predicted (ppVO2) reached. However, traditional standards by which ppVO2 calculated have limitations, having been derived from small cohorts, lacking portability poorly represented women. Thus, we aim to compare FRIEND Registry equation previously used methods...