A5039195747- ATP Synthase and ATPases Research
- Agricultural Productivity and Crop Improvement
- Mitochondrial Function and Pathology
- Soil and Environmental Studies
- Cancer, Hypoxia, and Metabolism
- Aerospace, Electronics, Mathematical Modeling
- Agriculture and Biological Studies
- Berberine and alkaloids research
- Traditional Chinese Medicine Analysis
- Plant Growth Enhancement Techniques
- Allelopathy and phytotoxic interactions
- Phytochemistry and Biological Activities
- Plant-based Medicinal Research
- Social and Educational Sciences
- Morphological variations and asymmetry
- Botany and Plant Ecology Studies
- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Essential Oils and Antimicrobial Activity
- Seedling growth and survival studies
- Immune Cell Function and Interaction
- Chemical Reactions and Isotopes
Columbus State Community College
2021-2024
National Research Tomsk State University
2020-2024
American Chemical Society
2024
A.N. Bukeikhan Kazakh Research Institute of Forestry and Agroforestry
2023
The Ohio State University Wexner Medical Center
2018-2021
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2018
The Ohio State University
2018
Tumor hypoxia reduces the effectiveness of radiation therapy by limiting biologically effective dose. An acute increase in tumor oxygenation before treatment should therefore significantly improve cell kill after radiation. Efforts to oxygen delivery have not shown positive clinical results. Here we show that targeting mitochondrial respiration results a significant reduction cells' demand for oxygen, leading increased and response. We identified an activity FDA-approved drug papaverine as...
Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle. PDC is conserved E1-E2-E3 with PDHA1 and PDHB heterotetramer functioning as E1 subunit. contains three serine residues that can be reversibly phosphorylated by dedicated family of four inhibitory pyruvate kinases (PDHK1-4) two reactivating phosphatases (PDP1, 2). Hypoxia induces expression PDHK1 PDHK3 hyperphosphorylates...
In the ever-evolving landscape of cancer research, immuno-oncology stands as a beacon hope, offering novel avenues for treatment. This study capitalizes on vast repository immuno-oncology-related scientific documents within CAS Content Collection, totaling over 350,000, encompassing journals and patents. Through pioneering approach melding natural language processing with indexing system, we unveil 300 emerging concepts, depicted in comprehensive "Trend Landscape Map". These spanning...
Recreational load affects the quality of environment, which is confirmed by change fluctuating asymmetry silver birch leaves. The deviation level environmental minimal when normal. However, declining it leads to decrease in stability and state biome, observed sign magnitude changes as integral indicator developmental stability. purpose research was study leaves ( Betula pendula Roth) green zone Astana. objects were 19-year-old artificial plantings birch, some underwent intercropping practice...
Abstract The aim of this research is to determine optimal methods using stimulants in a pre-sowing treatment common pine seeds increase their germination and obtain high-quality planting material. A study has been performed forest nurseries the State Forest Natural Reserve (SFNR) “Ertis Ormany” (Pavlodar region) Arykbalyk Branch National Park (SNNP) “Kokshetau” (Akmola region). done with one-and two-year-old seedlings ordinary sowing 2017. presowing seed preparation carried out according six...
Climate change, man-made and anthropogenic factors have negatively affected the flora, therefore, reserves of wild-growing grasses in nature are sharply reduced. For this reason, mass cultivation medicinal herbs on plantations is becoming an important task.
 Aim research – development environmentally friendly rational technology for growing northern region Kazakhstan.
 Materials methods. The was carried out Akmola region, following species were selected as objects research:...
The genus Nepeta exhibits a wide spectrum of biological activity in medicine, agriculture, and the food industry. purpose research is to develop optimal agricultural technology for plantation cultivation cataria L. with preservation useful properties increase content essential oil conditions Northern Kazakhstan. objects are annual plants N. growing on Akmola region. It has been reliably proven that growth L., biomass, yield positively affected by application complex fertilizer N100P80K120....
Abstract Radiation therapy is a standard type of treatment modality used to achieve local control in more than 50% all cancer patients. However, tumor hypoxia reduces the effectiveness radiation by limiting biologically effective dose. Limited distribution oxygen direct consequence abnormalities vascular structure and angiogenesis that fails provide sufficient meet demands metabolically hyperactive cells. An acute increase oxygenation prior should therefore significantly improve cell kill...
Radiation therapy is a standard type of treatment modality used to achieve local control in more than 50% all cancer patients. However, tumor hypoxia reduces the effectiveness radiation by limiting biologically effective dose. Limited distribution oxygen direct consequence abnormalities vascular structure and angiogenesis that fails provide sufficient meet demands metabolically hyperactive cells. An acute increase oxygenation prior should therefore significantly improve cell kill after...
The purpose of the research is to determine rate influence weather conditions on rapidity growth planting stock Pinus sylvestris. objects were annual seedlings P. sylvestris growing in forest nurseries Pavlodar, North Kazakhstan, Akmola and Municipal Public Institution "Forestry "Bukpa" Regions. At highest average temperature season a lower sum precipitation Pavlodar region, best indicators quality seeds observed over three-year period research. When air high enough during season, there was...