A5087275715- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- Cytomegalovirus and herpesvirus research
- Animal Virus Infections Studies
University of Minnesota Medical Center
2023-2024
University of Minnesota
2021
Glycoprotein C (gC), one of ∼12 HSV-1 envelope glycoproteins, carries out several important functions during infection, including the enhancement virion attachment by binding to host cell heparan sulfate proteoglycans (HSPG). Here we report that gC can also enhance release cell-free progeny virions at end infectious cycle. This activity was observed in multiple cellular contexts Vero cells and immortalized human keratinocytes. In absence gC, bound more tightly infected cells, suggesting...
Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This "dirty" mouse offers platform studying acute transmission of between within hosts via mechanisms. We identified numerous other microbial species that transmit to mice, including prospective new...
Herpes simplex virus type-1 (HSV-1) protein ICP27 is an essential immediate early (IE) that promotes the expression of viral (E) and late (L) genes via multiple mechanisms. Our understanding this complex regulatory has been greatly enhanced by characterization HSV-1 mutants bearing engineered alterations in gene. However, much analysis performed interferon-deficient Vero monkey cells. Here, we assessed replication a panel several other cell types. shows lacking ICP27's amino (N)-terminal...