THE STANdard curative treatment option for hepatocellular carcinoma (HCC).However, the rate of long-term disease-free survival after liver resection remains unsatisfactory due to persistent high incidences HCC recurrence. 1 Many factors affect recurrence risk resection, including tumor size and stage, serum ␣-fetoprotein level, cirrhosis, hepatitis B e antigen (HBeAg) status, virus (HBV) viral load. 2-4Among these factors, HBV load is most clinically controllable.Higher has been reported be...

Hepatitis C virus (HCV) infection is causally associated with insulin resistance and diabetes mellitus. This population-based cohort study aimed to investigate whether antiviral therapy for HCV was improved clinical outcomes related diabetes. From the Taiwan National Health Insurance Research Database, 2,267,270 Taiwanese residents diagnosed mellitus were screened eligibility. defined by a specific diagnosis code measurement of serum antibody. After excluding patients serious comorbidity, we...

Abstract A question central to the Covid-19 pandemic is why mortality rate varies so greatly across countries. This study aims investigate factors associated with cross-country variation in mortality. was calculated as number of deaths per 100 cases. To identify rate, linear regressions were applied a cross-sectional dataset comprising 169 We retrieved data from Worldometer website, Worldwide Governance Indicators, World Development and Logistics Performance Indicators databases. negatively...

To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV.This nationwide cohort study screened 293,480 Taiwanese residents HCV infection excluded those substantial comorbidity. A total of 12,384 eligible patients who had received pegylated interferon plus ribavirin 1 October 2003 31 December 2010 were enrolled treated cohort; they matched : 2 24,768 untreated controls propensity score post-diagnosis treatment-free period. The...

Abstract Diet and exercise are conventional methods for controlling body weight linked to alterations in gut microbiota. However, the associations of diet, exercise, microbiota control obesity remain largely unknown. In present study, using 16S rRNA amplicon sequencing fecal transplantation (FMT), normal fat diet (NFD), their combination resulted improved metabolic profiles comparison sedentary lifestyle with high (HFD). Moreover, exerted more influence than shaping HFD-fed mice receiving...

Abstract Hepatocellular carcinoma (HCC) is characterized by a poor prognosis and one of the leading causes cancer-related death worldwide. Simvastatin, an HMG-CoA reductase inhibitor, which decreases cholesterol synthesis inhibiting mevalonate pathways widely used to treat cardiovascular diseases. Simvastatin exhibits anticancer effects against several malignancies. However, molecular mechanisms underlying simvastatin on HCC are still not well understood. In this study, we demonstrated...

Abstract Objectives The intestinal microbiota has been known to involve in obesity and host immune response. We aimed investigate the potential genetic function relation clinical presentation psoriasis patients. Methods Faecal predicted inferred from high‐throughput 16S ribosomal RNA sequencing were analysed between (n = 32) age‐, gender‐ body mass index ( BMI )‐matched non‐psoriasis subjects 64), a referral medical centre. correlation altered disease activity, arthritis systemic...

Background Scientists have demonstrated the efficacy of vaccines against severe acute respiratory syndrome coronavirus 2 in randomized controlled trials.However, extent to which reductions COVID-19 case fatality ratio (CFR) are attributable mass vaccination real world remains unclear.This study evaluated association vaccine coverage with CFR on a global scale. MethodsThe sample was longitudinal data set 90 countries over 25 weeks, from first week November 2020 third April 2021.CFR measured...

Abstract Hepatocellular carcinoma (HCC) frequently recurs after surgical resection. This population-based research aimed to investigate the association between postoperative antiviral treatment and risk of recurrent HCC in patients with hepatitis C virus (HCV) infection. By analyzing Taiwan National Health Insurance Research Database, we initially screened a total 100,938 diagnosed for first time October 2003 December 2010. Among 2,237 antiviral-naïve HCV-infected curatively resected HCC,...

Abstract Subtotal gastrectomy ( i.e. , partial removal of the stomach), a surgical treatment for early-stage distal gastric cancer, is usually accompanied by highly selective vagotomy and Billroth II reconstruction, leading to dramatic changes in environment. Based on accumulating evidence strong link between human gut microbiota host health, 2-year follow-up study was conducted characterize effects subtotal gastrectomy. Gastric predicted gene functions inferred from 16S rRNA sequencing were...

Summary Background Finite nucleos(t)ide analogue (NUC) therapy has been proposed as an alternative treatment strategy for chronic hepatitis B (CHB). Aim To quantify the incidence of severe flares following NUC cessation in everyday clinical practice. Methods This population‐based cohort study enrolled 10,192 patients (male 71.7%, median age 50.9 years, cirrhosis 10.7%) who had received first‐line NUCs at least 1 year before discontinuing treatment. The primary outcome was flare with hepatic...

<h3>Objective</h3> Current guidelines recommend screening for hepatocellular carcinoma (HCC) in high-risk populations. However, the effectiveness of reducing mortality has been challenged. In addition, it is unclear which subgroups benefit most from HCC screening. <h3>Design</h3> This nationwide cohort study identified a total 52 823 newly diagnosed patients between 1 January 2002 and 31 December 2007. These were classified into following cohorts according to time intervals they received...

Abstract Introduction The association between cancer and use of biologic therapy among rheumatoid arthritis (RA) patients remains controversial. We aimed to compare the relative risk development RA taking tumor necrosis factor α (TNFα) antagonists those nonbiologic disease-modifying anti-rheumatic drugs (nbDMARDs). Methods conducted a nationwide cohort study 1997 2011 using Taiwan National Health Insurance Research Database. newly diagnosed was compared starting TNF-α (biologics cohort)...

In Brief Purpose: The efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) in reducing the risk various de novo cancers has been reported; however, its role hepatocellular carcinoma (HCC) recurrence after liver resection still remains unknown. Methods: We have conducted a nationwide cohort study by recruiting all patients with newly diagnosed HCC who had received curative as their initial treatment. use NSAIDs and early examined multivariate stratified analyses. To avoid immortal time...

Rosacea has been linked to inflammatory bowel disease and small bacterial overgrowth. We aimed investigate the fecal microbial profiling potential gene functions between rosacea non-rosacea subjects. A case-control study. Fecal microbiome predicted genetic function inferred from high-throughput 16S ribosomal RNA sequencing were analyzed (n = 11) age-, gender- body mass index-matched subjects (n=110). The correlation altered as well lifestyle diet also investigated. significant reduction of...

Gastric intestinal metaplasia (IM) has been known as a premalignant condition, but estimates of its cancer risk vary widely. We aimed to analyze gastric IM by long-term cohort study.We conducted hospital-based study that included all patients with between 1992 and 2010, the development adenocarcinoma was evaluated until July 2011. Patients developing ≤180 days after index diagnosis were excluded. The incidence rate, cumulative incidence, standardized ratio (SIR) determined, hazard ratios...

The relationship between cancer and vitiligo has been explored but with inconsistent results. To examine the long-term risk in patients, we conducted a retrospective nationwide cohort study. From National Health Insurance Research Database of Taiwan, total 13,824 patients were identified matched 55,296 reference subjects without by age, gender, propensity score estimated major comorbidities from 1997 to 2013. Demographic characteristics compared these two groups. Incidence rate ratios hazard...