Uncoupled bone remodeling in the subchondral (SB) has recently been considered as an important process progression of knee osteoarthritis (KOA). In this study, we aimed to investigate changes SB and articular cartilage using a mouse model destabilization medial meniscus (DMM) determine effects metabolism on KOA progression. DMM or sham surgery was performed left knees 40-week-old male wild-type (WT) mice Tsukuba hypertensive (THM), which exhibit high-turnover metabolism. Bone volume/tissue...

In 2013, we reported that local renin-angiotensin system (local RAS) components express during the hypertrophic differentiation of chondrocytes and can modulate it, using ATDC5 cell line involves from mesenchymal stem cells to calcified chondrocytes. However, expressions RAS in normal have not been revealed yet. The purpose this study is examine expression vivo conditions allowing expression. We stained five major regions 8-week-old C57BL/6 adult mice which exist, including epiphyseal plates...

Epidemiological studies have shown an association between hypertension and knee osteoarthritis (OA). The purpose of this study was to investigate whether activation the renin-angiotensin system (RAS) can aggravate mechanical loading-induced OA in mice. Eight-week-old male Tsukuba hypertensive mice (THM) C57BL/6 were divided into running non-running groups. Mice group forced run (25 m/min, 30 min/day, 5 days/week) on a treadmill. All four groups (n=10 each group) euthanized after 0, 2, 4, 6,...

A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report described the role of a RAS hypertrophic differentiation chondrocytes. To examine differentiation, we activated angiotensin II type 1 receptor (AT1R) and 2 (AT2R) separately cell line ATDC5, which involves from mesenchymal stem cells to Activation AT1R suppressed activation AT2R enhanced expression markers including X collagen, matrix metalloproteinase 13 runt-related...

Angiotensin II type 1 receptor (AT1R) appears to have a mechanosensing function in number of cell types. The purpose this study was examine whether AT1R expressed articular chondrocytes is involved osteoarthritis (OA) progression vivo and cyclic compressive loading activates the stimulates hypertrophic differentiation vitro. relationships between modified Mankin score for cartilage degeneration expression X collagen (Col X) were studied mouse knees with OA induced using...

There has been no consensus about how to determine the individual posterior tibial slope (PTS) intraoperatively. The purpose of this study was investigate whether plateau could be used as a reference for reproducing PTS during medial unicompartmental knee arthroplasty (UKA). Preoperative computed tomography (CT) data from 48 lower limbs UKA were imported into three-dimensional planning software. Digitally reconstructed radiographs created CT lateral plain and radiographic angle measured....

Previous studies have highlighted differences in the risk of periprosthetic fracture between tapered slip (TS) and composite beam (CB) stems. This biomechanical study explored fractures around these stems effect adding a 16-gauge calcar or diaphyseal wire to TS on their resistance torque. A power analysis determined sample size 7 specimens per group, assuming standard deviation 14.8 Nm peak torque, provide 90% detect difference at least 30 groups. Twenty-one (eight alone, six with wiring,...

ABSTRACT Introduction Acute Compartment Syndrome (ACS) is a severe trauma caused by elevated intra-muscle-compartment pressure (ICP). The current standard method for diagnosis to insert needle into the muscle sterilely under anesthesia. However, secure environment sometimes not easy and leads delays in diagnosis. Recently, we have focused on shear wave ultrasound elastography (SWE) as an alternative, which can be done concisely unclean without We would like report usefulness of SWE ACS using...

Synovial osteochondroma (SO) is a relatively uncommon tumor affecting the synovial joints that characterized by development of hyaline cartilage from membrane. The basic pathophysiology SO thought to be metaplastic change synovium cartilage. Large extra‑ or para‑articular lesions in Hoffa's fat pad are uncommon. A 56‑year‑old woman complained knee pain associated with large lesion on anterior right knee. She also had restricted range motion Examination revealed an elastic hard 8x9‑cm...

In designing bone fillers, hardness has heretofore not been a major concern. Fillers are typically very hard and thus often accelerate the collapse of adjacent bones. We developed novel, relatively soft filler, whose is similar to human cancellous bone. The structure simple: 0.14-mm-diameter pure titanium wire was rolled folded with both ends buried in central portion, resulting ball 4-mm diameter 83% internal void ratio, having 300-500 μm gaps. balls chemically washed an acidic solution at...

There is no consensus on intraoperative references for the posterior tibial slope (PTS) in medial unicompartmental knee arthroplasty (UKA). An arthroscopic hook probe placed second quarter of plateau (MTP) an anteroposterior direction may be used as a direct anatomical reference PTS. The purpose this study to investigate availability and accuracy method.Marginal osteophyte formation subchondral depression MTP angles between bony cartilage were retrospectively evaluated using preoperative...

Abstract Introduction: Recently, uncoupled bone remodeling in the subchondral (SB) has been considered an important process to promote knee osteoarthritis (KOA). However, it is unclear how SB metabolism early stage of KOA affects initiation and progression disease. This study aimed investigate relationship between changes disease process, using wild-type (WT) mice Tsukuba hypertensive (THM) with high-turnover metabolism. Methods Destabilization medial meniscus (DMM) or sham surgery was...