A5045212907- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Medicinal Plants and Neuroprotection
- Inflammasome and immune disorders
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Fibroblast Growth Factor Research
- Medicinal Plant Pharmacodynamics Research
- Saffron Plant Research Studies
- Toxin Mechanisms and Immunotoxins
- Sirtuins and Resveratrol in Medicine
- Electric Vehicles and Infrastructure
- Ion Channels and Receptors
- Invertebrate Immune Response Mechanisms
- Phytochemistry and Bioactivity Studies
- Cardiovascular Function and Risk Factors
- Biological Stains and Phytochemicals
- Cardiac pacing and defibrillation studies
- Medicinal Plants and Bioactive Compounds
- Peroxisome Proliferator-Activated Receptors
Shanghai University of Medicine and Health Sciences
2021-2024
Shandong University
2023
Shanghai Medical College of Fudan University
2023
Pudong New Area People's Hospital
2015
Shanghai East Hospital
2014
Introduction: Inflammatory cytokines are closely associated with developing cardiac fibrosis. This research aimed to explore the significant role of IL-11 in atrial fibrosis progression and potential therapeutic targets. Methods: 207 AF patients 160 healthy subjects were included case-control study. Blood samples analyzed for level by enzyme-linked immunosorbent assay (ELISA). Angiotensin II (Ang II)-treated mouse models generated, expression mRNA protein was detected RT-qPCR Western blot....
Atrial fibrillation (AF) is the more significant portion of arrhythmia in clinical practice, with inflammation and fibrosis as its central pathological mechanisms. This study aimed to investigate angiopoietin-like 4 (ANGPTL4) effects on angiotensin II- (Ang II-) induced AF related pathophysiological C57BL/6J mice were randomized divided into three groups: control group, Ang II ANGPTL4 group treatment). Mice infused (2000 ng/kg/min) administrated recombinant human (rhANGPTL4, 20 μg/kg/day)...
Astragaloside IV (AS-IV) has been found to possess anti-oxidative, anti-inflammatory, and anti-apoptotic properties, but its effect on atrial fibrosis is yet be determined. This research investigates the protective role of AS-IV in angiotensin II (Ang II)-induced fibrillation (AF).
Under a two-part tariff, the user-side installation of photovoltaic and energy storage systems can simultaneously lower electricity charge demand charge. How to plan capacity location against backdrop fully installed system is critical element in determining economic benefits users. In view this, we propose an optimal configuration for multi-transformer-integrated industrial park microgrid. First, objective function planning built with income cost whole life cycle as core elements. This...
Cardiac fibrosis is a key biological process of cardiac remodeling and heart failure. Fatty acid-binding protein 4 (FABP4) lipid-binding that can regulate glucose lipid homeostasis, its expression was elevated in However, whether FABP4 involved remains unknown.The model established male C57BL/6 mice with subcutaneously infused angiotensin II (Ang-II) (2.8 mg/kg/day) for weeks. DMSO or inhibitor BMS309403 (50 intraperitoneally injected Ang II-infused mice, (BMS309403) ventricular tissue were...
Corilagin (Cor) is reported as beiing hepatoprotective, anti-inflammatory, antibacterial, and anti-oxidant, while the effect on atrial fibrosis remains unknown. Therefore, we investigated protective of Cor in angiotensin II (Ang II)-induced fibrillation (AF).
Slit guidance ligand 3 (SLIT3) has been identified as a potential therapeutic regulator against fibroblast activity and fibrillary collagen production in an autocrine manner. However, this research aims to investigate the role of SLIT3 cardiac fibrosis differentiation its underlying mechanism.
This research aimed to evaluate the therapeutic effect of corilagin (Cor) against angiotensin II (Ang II)-induced cardiac fibrosis and its underlying mechanisms. C57BL/6 mice (male, 8-10 weeks) received saline or Ang (2.0 mg/kg/day) via subcutaneous infusion intraperitoneal injection Cor (30 mg/kg) for 28 days. induction increased fibrotic area, whereas treatment inhibited area significantly. markedly reduced II-induced fibroblasts. significantly increase in expressions smooth muscle...
To discuss whether asiaticosides could effectively reduce the endothelial cell damage as a biochemical modulator, so to further inhibit post-stenting intima-media membrane hyperplasia.Human aortic smooth muscle cells and fibroblasts were selected divided into blank group, rapamycin group asiaticoside group. The expressions of TGF-beta1, Smad7 I-collagen gene determined by RT-PCR. expression quantity protein was assayed ELISA. coefficient drug interaction (CDI) between calculated....
To investigate the effect of stromal interaction molecule 1(STIM1) knockdown on proliferation and migration endothelial progenitor cells (EPCs) after vascular injury its mechanism.The rat bone marrow derived EPCs were divided into three groups: adenovirus negative control (group NSC), STIM1 vector transfection group si/rSTIM1) &human recombinant si/rSTIM1+hSTIM1). The expressions in each detected by reverse transcription PCR transfection; cell was tested [(3)H] thymidine incorporation assay...
Abstract Purpose Inflammatory cytokines are closely associated with developing cardiac fibrosis. This research aimed to explore the significant role of IL-11 in atrial fibrosis progression and potential therapeutic targets. Methods 367 subjects were included case-control study. Blood samples analyzed for level by enzyme-linked immunosorbent assay (ELISA). Angiotensin II (Ang II) treated mouse models generated expression mRNA protein detected RT-qPCR western blot. antagonist was used evaluate...
At present, the prediction of adverse events (AE) had practical significance in clinic and accuracy AE model after left atrial appendage closure (LAAC) needed to be improved. To identify a good based on machine learning for short- long-term LAAC.In this study, 869 patients were included from Department Cardiovascular Medicine Shanghai University Health Sciences Affiliated Zhoupu Hospital during 2017 2021. Univariate multivariate analyses conducted short-term LAAC determine possible risk...