A5063391576- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Immunodeficiency and Autoimmune Disorders
- Ethics in Clinical Research
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Malaria Research and Control
- Meta-analysis and systematic reviews
University of Puerto Rico System
2021-2022
University of Puerto Rico, Medical Sciences Campus
2017-2021
National Alliance for Hispanic Health
2021
The demand for clinical trial participants is today one of the highest it has ever been and continues to increase. At same time, subject recruitment be problematic major reason premature terminations. literature on recruitment, which spans several decades includes hundreds studies, an abundance findings that can synthesized by way overview provide a well-informed complete picture factors determine participation.An systematic reviews report barriers facilitators participation was conducted....
Dengue (DENV) is a mosquito-borne virus with four serotypes causing substantial morbidity in tropical and subtropical areas worldwide. V181 an investigational, live, attenuated, quadrivalent dengue vaccine. In this phase 1 double-blind, placebo-controlled study, the safety, tolerability, immunogenicity of baseline flavivirus-naïve (BFN) flavivirus-experienced (BFE) healthy adults were evaluated two formulations: TV003 TV005. TV005 contains 10-fold higher DENV2 level than TV003. Two-hundred...
One combined measles-mumps-rubella (MMR) vaccine without Human Serum Albumin (HSA) is currently licensed in the USA (M-M-R II; Merck, USA) and another has been developed (Priorix™ [MMR-RIT, GSK, Belgium]). In this follow-up study, children from or Puerto Rico, who had received one dose of M-M-R II MMR-RIT at 12–15 months age primary study (NCT00861744), were followed-up for 2 y post-vaccination. Anti-measles anti-rubella antibodies measured using Enzyme-Linked Immunosorbent Assay (ELISA),...
Abstract Background Dengue (DENV) is a mosquito-borne virus with four serotypes causing substantial morbidity in tropical and subtropical areas worldwide. A dengue vaccine that can be given to both seronegative seropositive populations remains an important unmet medical need. V181 investigational live, attenuated, quadrivalent vaccine. Methods In this phase 1 double-blind, placebo-controlled study, the safety, tolerability, immunogenicity of healthy adults were evaluated two formulations:...