A5073152424- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Biomedical Text Mining and Ontologies
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Semantic Web and Ontologies
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Health, Medicine and Society
- Tuberous Sclerosis Complex Research
- Global Cancer Incidence and Screening
- Vascular Tumors and Angiosarcomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Oral health in cancer treatment
University of Chicago Medical Center
2025
University of Chicago
2024
University at Buffalo, State University of New York
2017-2024
Jacobs Institute
2018-2021
Roswell Park Comprehensive Cancer Center
2017-2018
Various methods exist to correct for intrafraction motion (IFM) of the prostate during radiotherapy. We sought characterize setup corrections in our practice informed by TrueBeam Advanced imaging package, and analyze factors associated with IFM. 132 men received radiation therapy cancer a volumetric modulated arc technique. All patients underwent planning CT immediately following transrectal placement 3 fiducial markers. The most common RT course was 20 fractions (range: 17-44). Triggered kV...
The purpose of this study was to evaluate nationwide trends in pathologic complete response (pCR) and its racial variations for breast cancer. National Cancer Database queried women from 2010 2017 with non-metastatic cancer who underwent neoadjuvant chemotherapy. primary endpoints, pCR overall survival, were evaluated using Cochran-Armitage test, logistic, Cox regression multivariable analyses. A total 104,161 analyzed. Overall, improved (15.1% 27.2%, trend p < 0.001). Compared...
Osteoporosis is the most common cause of vertebral collapse, which significantly impairs mobility and quality life. Primary management consists conservative therapeutic measures such as analgesics, bed rest, external bracing rehabilitation. Percutaneous vertebroplasty for treatment osteoporotic compressive fractures has gained popularity during last decade. The limited invasiveness encouraging results obtained in patients with symptomatic compression have favored an extensive use procedure...
Within the cancer domain, ontologies play an important role in integration and annotation of data order to support numerous biomedical tools applications. This work seeks leverage existing standards immunophenotyping cell types found hematologic malignancies provide ontological representation them aid analysis for patient data.We have developed Cancer Cell Ontology according OBO Foundry principles as extension Ontology. We define classes by using a genus-differentia approach logical axioms...
Abstract Background This National Cancer Database (NCDB) analysis evaluates the clinical outcomes of postoperative chemotherapy followed by concurrent chemoradiation (C + CRT) compared to (CRT) alone or adjuvant (C) for resected pancreatic cancer. Methods The NCDB was queried primary stage I‐II, cT1‐3N0‐1M0, adenocarcinoma treated with C, CRT, C CRT (2004‐2015). Patients were those (cohort C) and CRT). Baseline patient, tumor, treatment characteristics examined. Kaplan‐Meier analysis,...
Stem cells and stem cell lines are widely used in biomedical research. The Cell Ontology (CL) Line (CLO) two community-based OBO Foundry ontologies the domains of vivo vitro line cells, respectively. To support standardized investigations, we have developed an for Investigations (OSCI). OSCI imports terms from CL CLO, investigation-related existing ontologies. A novel focus is its application representing metadata types associated with various investigations. We also applied to...
372 Background: Prior National Cancer Database (NCDB) studies have demonstrated an overall survival (OS) benefit for adjuvant concurrent chemoradiation (CRT) compared to chemotherapy alone. Given the more recent adoption of postoperative followed by (C+CRT), this NCDB analysis evaluates clinical outcomes C+CRT CRT alone or (C) resected pancreatic cancer. Methods: The was queried primary stage I-II, cT1-3N0-1M0, adenocarcinoma treated with C, CRT, (2004-2015). Patients were those C (cohort C)...
Abstract Aim: Induction chemotherapy (iC) followed by concurrent chemoradiation has been shown to improve overall survival (OS) for locally advanced pancreatic cancer (LAPC). However, the benefit of stereotactic body radiation therapy (SBRT) versus conventionally fractionated (CFRT) following iC remains unclear. Materials and methods: The National Cancer Database (NCDB) was queried primary stage III, cT4N0-1M0 LAPC (2004–15). Kaplan–Meier analysis, Cox proportional hazards method propensity...
Abstract Aim: This National Cancer Database (NCDB) analysis was performed to evaluate the outcomes of adjuvant chemotherapy (AC) versus observation for resected pancreatic adenocarcinoma treated with neoadjuvant therapy (NT). Materials and methods: The NCDB queried primary stages I–II cT1-3N0-1M0 NT (2004–2015). Baseline patient, tumour treatment characteristics were extracted. end point overall survival (OS). With a 6-month conditional landmark, Kaplan–Meier analysis, multivariable Cox...
378 Background: Induction chemotherapy (iC) followed by concurrent chemoradiation has been shown to improve overall survival (OS) for locally advanced pancreatic cancer (LAPC). A recent National Cancer Data Base (NCDB) analysis also improved OS with the use of stereotactic body radiation therapy (SBRT) versus conventionally fractionated (CFRT). This NCDB evaluated outcomes SBRT compared CFRT, following iC. Methods: The was queried primary stage III, cT4N0-1M0 unresected adenocarcinoma...
Magnetic resonance imaging of the brain is a useful tool in both clinic and research settings, aiding diagnosis treatments neurological disease expanding our knowledge brain. However, there are many challenges inherent managing analyzing MRI data, due large part to heterogeneity data acquisition.
375 Background: For resected early-stage pancreatic cancer, RTOG 9704 has evaluated the outcome of 3 weeks adjuvant chemotherapy (C) followed by chemoradiation (CRT) and post-CRT C. locally advanced a recent literature review showed that typical duration for induction C is between 1 6 months prior to CRT. The ideal CRT remains unclear. This National Cancer Database (NCDB) study was performed identify optimal in patients with cancer. Methods: NCDB queried primary stage I-II, cT1-3N0-1M0, III,...