A5063607351- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Chronic Disease Management Strategies
- Pharmacology and Obesity Treatment
- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Dietary Effects on Health
- Myasthenia Gravis and Thymoma
- Bone health and treatments
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Trauma and Emergency Care Studies
- Growth Hormone and Insulin-like Growth Factors
- Botulinum Toxin and Related Neurological Disorders
- Regulation of Appetite and Obesity
- Clinical practice guidelines implementation
- Cardiac Health and Mental Health
- Eating Disorders and Behaviors
- Autopsy Techniques and Outcomes
- Cardiovascular and exercise physiology
Dubai Hospital
2021-2025
Dubai Health Authority
2012-2022
Dubai Medical College
2020
Research Institute for Endocrine Sciences
1998
University of Minnesota Rochester
1998
Mayo Clinic
1995-1997
University of Utah
1995
Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by genetic environmental factors. T2DM associated with long-term complications that have contributed the burden of morbidity mortality worldwide. The objective this manuscript conduct an Exome-Wide Association Study (EWAS) on Emirati individuals improve our understanding diabetes-related early diagnostic methods treatment strategies.
The prevalence of painful diabetic peripheral neuropathy (DPN) was evaluated in type 1 or 2 diabetes mellitus patients (n = 4097) attending outpatient clinics across the Middle East. Overall, 53.7% 3989 with DN4 data met criteria for DPN (Douleur Neuropathique-4 [DN4] scores ≥ 4). Significant predictors included long history (≥ 10 years) (odds ratio [OR] 2.43), age 65 years (OR 2.13), 50 - 64 1.75), presence versus 1.59), body mass index > 30 kg/m(2) 1.35) and female gender 1.27). Living one...
Background: Lipohypertrophy is a common complication in patients with diabetes receiving insulin therapy. There lack of consensus regarding how much lipohypertrophy affects management. Our study aimed to assess the potential correlation between and glycemic control, as well dosing diabetes. Methods: We performed systematic review followed by meta-analysis collect data about control diabetic without lipohypertrophy. To identify relevant studies published English, we searched medical databases...
To assess, in a real-world setting, the effect of vildagliptin compared with sulphonylurea (SU) treatment on hypoglycaemia Muslim patients type 2 diabetes mellitus (T2DM) fasting during Ramadan.This multinational, non-interventional study, conducted Asia and Middle East, included adult T2DM who received or SU as add-on to metformin monotherapy. During ~16-week observation period, data were collected up 6 weeks before after Ramadan fasting. The primary study objective was compare proportion ≥...
Abstract Background There has been a rapid increase in the incidence and prevalence of metabolic dysfunction-associated liver disease (MASLD) Middle East Africa (MEA) regions. Methods We aimed to assess knowledge awareness MASLD among MEA physicians evaluate their current approach diagnosing, managing, referring MASLD. used an online survey through validated questionnaire convenience sample clinicians examine knowledge, practices, attitudes regarding barriers providing care for this...
Hepatitis C-associated osteosclerosis (HCAO) is a rare disorder characterized by marked increase in bone mass during adult life. Despite the rarity of HCAO, understanding mediator(s) skeletal disease great interest. The IGFs-I and -II have potent anabolic effects on bone, alterations IGFs and/or IGF-binding proteins (IGFBPs) could be responsible for formation this disorder. Thus, we assayed sera from seven cases HCAO IGF-I, IGF-II, IGF-IIE (an IGF-II precursor), IGFBPs. distribution serum...
Aims There is a large population of people with type 2 diabetes mellitus (T2DM) who are Muslim and fast during Ramadan. Changes in the pattern amount meal fluid intake Ramadan, addition to long fasting hours, may increase risk hypoglycaemia, hyperglycaemia, dehydration. The Canagliflozin Ramadan Tolerance Observational Study (CRATOS) evaluated tolerability canagliflozin, sodium glucose co-transporter inhibitor, compared sulphonylureas among patients T2DM Methods This non-randomised,...
Among patients with type 2 diabetes, insulin intensification to achieve glycemic targets occurs less often than clinically indicated. Barriers are not well understood. We present patients' baseline characteristics from MOSAIc, a study investigating patient-, physician-, and healthcare environment-based factors affecting subsequent health outcomes. MOSAIc is longitudinal, observational following diabetes care in 18 countries: United Arab Emirates (UAE), Argentina, Brazil, Canada, China,...
The American Diabetes Association and the European for Study of guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management glucose-lowering drugs decrease burden diabetes-related complications. This real-world practice study aimed assess predictive factors achieving glycemic hemoglobin A1c (HbA1c) at 6 months as targeted treating physician adults with type 2 diabetes who required initiation basal insulin, bolus or...
Background . Transcription factor 7-like 2 gene ( TCF7L2 ) and peroxisome proliferator-activated receptors- γ PPAR- have a profound effect on the incidence of type diabetes mellitus (T2DM) had previously been found to be associated with T2DM risk in various ppopulations. However, studies Arab population are inconsistent. We conducted case control study confirm association variants rs10885409 Pro12Ala (rs1801282) related complications Emirati origin. also investigated interaction these...
Rapid urbanisation and socioeconomic development in the United Arab Emirates (UAE) have led to widespread adoption of a sedentary lifestyle Westernised diet local population consequently high prevalence obesity diabetes. In 2019, International Diabetes Federation statistics reported diabetes rate 16.3% for adult UAE. view wealth recent literature on care new pharmacotherapeutics, Society convened panel experts update existing guidelines with international management recommendations. The goal...
Insular thyroid carcinoma, which is intermediate in aggressiveness and morphology between well differentiated anaplastic carcinomas, exceptionally rare children. The authors describe two children with this carcinoma who had different outcomes.
The effectiveness and safety of long-acting insulin glargine U300 (Gla-300), in patients with type 2 diabetes mellitus (T2DM) requiring insulin, has not been reported the Gulf region. Insulin-naïve T2DM, uncontrolled on OADs, prescribed Gla-300 were followed up a 12-month prospective observational study. was titrated to glycemic targets. primary endpoint (achieving targets) evaluated at month 6 treatment. need for treatment intensification, safety, patient-reported outcomes (PRO) also...
Current and future estimates of the burden diabetes in Middle East North Africa (MENA) region are among highest world. VISION, an 18-month observational study, explored patterns insulin initiation intensification T2DM patients MENA region.1192 aged ≥18 years were enrolled from Algeria, Egypt, Saudi Arabia UAE. Treating physicians recorded participants' data. Patient-reported outcomes (PROs) assessed using questionnaires completed by participants.67.6% had HbA1c ≥9% at initiation, with a mean...
The association of Angiotensin Converting Enzyme ( ACE ) insertion-deletion (I/D) polymorphism with Type 2 Diabetes Mellitus (T2DM) and hypertension has been extensively studied throughout various ethnic populations but largely inconsistent findings. We investigated these associations in Emirati population their interaction obesity status. Saliva samples were collected from a total 564 Emiratis (277 T2DM 297 healthy). DNA was extracted the genotyped for I/D by PCR based method followed gel...
Aims Developing countries face a high and growing burden of type 2 diabetes. We surveyed physicians in diverse range the Middle East Africa (Egypt, Kingdom Saudi Arabia, United Arab Emirates, South Lebanon) with regard to their perceptions barriers diabetes care identified as potentially important literature by authors. Methods One thousand eighty-two completed questionnaire developed Results Most enroled study employed guideline-driven care; 80–100% prescribed metformin (with lifestyle...