A5083916718- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Infant Nutrition and Health
- Lysosomal Storage Disorders Research
- Polysaccharides Composition and Applications
- Carbohydrate Chemistry and Synthesis
- Dye analysis and toxicity
- Osteoarthritis Treatment and Mechanisms
- Trypanosoma species research and implications
- Protease and Inhibitor Mechanisms
- Glycogen Storage Diseases and Myoclonus
- Neonatal Respiratory Health Research
- Tendon Structure and Treatment
- Protein Hydrolysis and Bioactive Peptides
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Calpain Protease Function and Regulation
- Microfluidic and Capillary Electrophoresis Applications
- Biochemical Analysis and Sensing Techniques
- Botanical Studies and Applications
- Plant Surface Properties and Treatments
- Escherichia coli research studies
- Cytomegalovirus and herpesvirus research
- Insect and Pesticide Research
- Synthesis of Organic Compounds
- Acoustic Wave Resonator Technologies
University of Modena and Reggio Emilia
2015-2022
Fidia Farmaceutici (Italy)
1978
Chondroitin sulfate/dermatan sulfate (CS/DS) was extracted from Atlantic bluefin tuna (Thunnus thynnus) skin (SGAT) and purified characterized. SGAT characterized by acetate cellulose electrophoresis, FTIR spectroscopy, 13C NMR spectroscopy SAX-HPLC. According to the results obtained for specific chondroitinases (ABC AC) SAX-HPLC separation of generated unsaturated repeating disaccharides, polymer found contain a disaccharide monosulfated in positions 6 4 GalNAc disulfated disaccharides...
Abstract The pharmacokinetic profile of a new 800‐mg tablet nonanimal chondroitin sulfate (CS) (Mythocondro®, tablets, Gnosis S.p.A., Italy) was investigated vs an animal CS in healthy volunteers for total period 48 hours. After single 2400‐mg dose the test and reference formulation, CS, compositional disaccharides (ΔDi6S, ΔDi4S ΔDi0S), overall charge density were quantified plasma. safety tolerability after this tablets excellent. baseline‐corrected concentrations, greater plasma...
Chondroitin sulfate (CS) is a linear heteropolysaccharide of repeating disaccharide units bearing groups in various positions, commonly at C4 and/or C6 galactosamine. CS plays important roles (patho)physiological processes also performing intriguing biological and therapeutical activities. Plasmatic mainly composed nonsulfated 4-sulfated disaccharides. To obtain samples for the determination amount composition blood/plasma, dried blood spot (DBS) could be used. DBSs have many advantages over...
It has recently been demonstrated that chronic supplementation with nonanimal chondroitin sulfate (nonanimal CS) in overweight subjects knee osteoarthritis (OA) improves the function, pain and inflammation, but there are no studies of its effectiveness an acute setting. In 48 obese moderate OA, we investigated CS for eight weeks on functional status, oxidative stress, cartilage catabolism markers, metabolic profile body composition, by Dual-Energy X-ray Absorptiometry (DXA) at baseline,...
Propolis is important in complementary and alternative medicine having well-known therapeutic applications. Artepillin C, a main component of Brazilian (green) propolis, has attracted great attention for its anticancer action. Consequently, the synthesis artepillin C been reported but, due to limited yield elevated costs, this biomolecule largely produced from propolis. We report capillary electrophoresis (CE) separation propolis also comparing results with those HPLC-UV-MS. Optimal was...
Abstract Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of lysosomal hydrolase iduronate 2-sulfatase (IDS). This leads severe clinical condition caused by multi-organ accumulation glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids. Since 2006, enzyme replacement therapy (ERT) has been clinically applied, showing efficacy some peripheral districts. In addition monitoring, GAG dosage...