A5010860413- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Endoplasmic Reticulum Stress and Disease
- Neural and Behavioral Psychology Studies
Harvard University
2020-2024
Stanford University
2020
Columbia University Irving Medical Center
2017
Columbia University
2017
Making the right contacts Contacts between endoplasmic reticulum (ER) and mitochondria mediate key physiological processes such as Ca 2+ exchange lipid biogenesis. wiIn yeast, ER are tethered by a complex of four proteins called ERMES. However, no functional orthologs these ERMES have been identified in metazoans. Hirabayashi et al. PDZD8 structural ortholog yeast protein MMM1 (see Perspective Lombardi Elrod). was found at ER-mitochondria contact sites required for tethering mammalian cells....
Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how secretory system is built support fast and slow neuromodulation not known. Here, we set out identify Ca2+-triggering mechanisms for release. We find that synchronous secretion abolished in acute brain slices of conditional knockout mice which Synaptotagmin-1 removed from neurons. This indicates Ca2+...