A5069565002- Meningioma and schwannoma management
- Melanoma and MAPK Pathways
- Insect and Pesticide Research
- Intracranial Aneurysms: Treatment and Complications
- Cutaneous Melanoma Detection and Management
- Neurofibromatosis and Schwannoma Cases
- Vector-borne infectious diseases
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Insect Pest Control Strategies
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Cancer Cells and Metastasis
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Epigenetics and DNA Methylation
- Fetal and Pediatric Neurological Disorders
- Viral Infections and Vectors
- Spinal Dysraphism and Malformations
- Mast cells and histamine
- RNA regulation and disease
- Plant Parasitism and Resistance
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
Sree Chitra Thirunal Institute for Medical Sciences and Technology
2015-2024
Kerala Veterinary and Animal Sciences University
2015-2024
Institute of Medical Sciences
2015-2023
Portsmouth Hospitals NHS Trust
2023
All India Institute of Medical Sciences Bhopal
2020
Michigan Cancer Research Consortium
2020
Regional Cancer Center, Thiruvananthapuram
2016
Inform (Germany)
2016
Lehigh Valley Hospital-Pocono
2015
Lehigh Valley Health Network
2015
Objective To evaluate the feasibility of using 68Ga PSMA-11 PET/CT for imaging brain lesions and its comparison with 18F-FDG. Methods Ten patients were included in study. Five treated cases glioblastoma suspected recurrence. 18F-FDG scans done these patients. sent assessing nature (primary lesion/metastasis) space occupying lesion brain. They underwent whole body scan a primary site elsewhere was ruled out. Subsequently they imaging. Target to background ratios (TBR) calculated contralateral...
Context With the advent of new imaging modalities, radiologists are faced with handling increasing volumes data for diagnosis and treatment planning. The use automated intelligent systems is becoming essential in such a scenario. Machine learning, branch artificial intelligence, increasingly being used medical image analysis applications as segmentation, registration computer-aided detection. Histopathological currently gold standard classification brain tumors. machine learning algorithms...
Vestibular schwannomas (VS) may be difficult to differentiate from cerebellopontine angle (CPA) meningiomas. Demonstration of microhemorrhages in VS on T2*-weighted gradient-echo (GRE) sequences have potential value CPA meningiomas.In this prospective study 20 patients, MR imaging was performed with GRE addition all basic sequences. Histopathologic examination after surgery. Intratumoral hemosiderin confirmed by pigment staining.There were 15 patients the group 16 and 5 meningioma posterior...
To study the effect of ethanolic extract leaves plant Jatropha curcas as a step towards developing safe and ecofriendly therapeutic agent to combat problems tick tick-borne diseases. Pulverised J. were subjected soxhlet extraction using ethanol. The at different dilutions such as, 50, 60, 70, 80, 90 100 mg / ml tested against ticks adult immersion test. per cent mortality, inhibition fecundity hatching laid ova studied. caused significant blocking by treated ticks. Eclosion is promising...
Magnesium sulphate commonly known as Epsom salt is used in aquaculture order to treat intestinal problems related digestion or parasites. In the present study an effort was made understand toxicity of magnesium sub adults Oreochromis niloticus (82± 4.5g). Acute test by bath treatment done exposing fish at concentrations 0 gL-1, 10 gL-1 30 gL-1and 60 gL-1as per OECD 203 guidelines for 96 hours. oral Limit 425 guidelines. After completion experimental period, blood collected and hematological...
A randomized three-arm phase II study was undertaken to evaluate the optimum administration schedule of pemetrexed and gemcitabine in chemotherapy-naïve patients with non-small-cell lung cancer.Patients were randomly assigned three schedules 500 mg/m2 plus 1,250 mg/m2, separated by a 90-minute interval, on 21-day cycle as follows: A, followed day 1 8; B, C, 8.One hundred fifty-two eligible (schedule n = 59; 31, 62) received median five A), two B), four C) treatment cycles. Overall, 66%...
<i>Background:</i> Aneurysmal subarachnoid hemorrhage (aSAH) has a mortality rate as high 50%. The prevalence of intracranial aneurysms from various parts India varies 0.75 to 10.3%, with higher numbers cases being diagnosed due the increasing age population and improvements in imaging techniques. However, little is known about attributable risk factors aSAH Indian population. <i>Methods:</i> Using case-control study we estimated such hypertension, cigarette smoking,...
Intracranial aneurysm (IA) is often asymptomatic until the time of rupture resulting in subarachnoid hemorrhage (SAH).There no precise biochemical or phenotype marker for diagnosis aneurysm. Environmental risk factors that associate with IA can result modifying effect inherited genetic and thereby increase susceptibility to SAH. In addition subsequent aneurismal rupture, nature quantum inflammatory response might be critical repair. Therefore, liability caused by polymorphisms cytokine genes...
A very high prevalence of microfilaremia 42.68 per cent out 164 canine blood samples examined was observed in Cherthala (of Alappuzha district Kerala state), a known human Brugia malayi endemic area south India. The species microfilariae were identified as Dirofilaria repens, , and Acanthocheilonema reconditum . D. repens the most commonly detected followed by B. pahangi immitis not any examined. Based on molecular techniques, with histochemical staining pattern “local at anal pore diffuse...
Lateral ventricular meningiomas are rare tumours that pose considerable surgical challenge. This study attempts to analyse some of the important clinical features these and review technical considerations in surgery for lateral meningiomas. A retrospective analysis case records patients with operated our institute since 1998 a minimum one year follow up was done. The variables analysed included age, sex, presentation, imaging characteristics, histopathology operative details. Outcome using...
Abstract BACKGROUND: The current study was conducted to assess the efficacy and toxicity of sorafenib as front‐line therapy in patients with stage IIIB (pleural effusion) or IV nonsmall cell lung cancer (NSCLC). METHODS: Patients received 400 mg twice daily by mouth continuously, were evaluated every 2 weeks during first 8 weeks. who manifested clinical progression this period proceeded receive standard care. primary endpoint confirmed objective tumor response. A 2‐stage Fleming design used...
This study investigated the effects of sequentially administered recombinant interferon gamma (rIFN gamma) and alfa alpha) in 36 patients with metastatic renal cell carcinoma (RCC). rIFN alpha was subcutaneously daily for 70 days at dosages that varied (2.5, 5, 10, 20 x 10(6) U/m2) across four cohorts patients. Within each cohort receiving a given dose alpha, three subsets received either 30, 300, or 1,000 micrograms/m2 gamma. intravenously 5 every third week, 6 hours prior to administration...
Ewing's sarcoma is a primary bone malignancy with the highest incidence in second decade of life. Although it mostly affects metaphyseal region long growing bones, involvement spine not very uncommon especially sacrum. Nonsacral spinal rarer and often mimics benign condition before spreading extensively. They present neurologic deficits due to cord compression, but acute onset paraplegia has been previously reported. A high index clinical suspicion can clinch diagnosis early course disease....
Intracranial aneurysm (IA) accounts for 85% of Subarachnoid Hemorrhage (SAH) and is mainly caused due to the weakening arterial wall. The structural integrity intracranial arteries influenced by extracellular matrix (ECM) remodeling. Proteoglycan Versican plays an important role in assembly a major pathogenesis IA. linkage studies also indicated VCAN as putative candidate gene IA 5q22-31 region. Using case-control study design, we tested hypothesis whether variants gene, nonsynonymous coding...
Background: Cystic vestibular schwannomas (VS) form a rare subgroup that differs from the solid variant clinically, radiologically, and histopathologically. These tumors also vary in their surgical outcome carry different risk of post-operative complications. We analyzed our series 64 patients with cystic VS discuss technical difficulties related to total excision these focus on complication avoidance. Materials Methods: A retrospective review surgically managed over span 11 years. The case...