A5026916725- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Primate Behavior and Ecology
- Voice and Speech Disorders
- Digital Mental Health Interventions
- Speech and Audio Processing
- Virology and Viral Diseases
- Action Observation and Synchronization
- Metabolism and Genetic Disorders
- Speech Recognition and Synthesis
- Genomics and Rare Diseases
- RNA regulation and disease
Massachusetts General Hospital
2021-2024
Harvard University
2022-2024
Hartford Financial Services (United States)
2021
Trinity College
2021
Abnormal eye movements occur early in the course of disease many ataxias. However, clinical assessments oculomotor function lack precision, limiting sensitivity for measuring progression and ability to detect subtle signs. Quantitative assessment during everyday behaviors such as reading has potential overcome these limitations produce functionally relevant measures. In this study, we analyze individuals with ataxia passage reading. Binocular gaze sampled at 1000 Hz was collected from 102...
Objective, sensitive, and meaningful disease assessments are critical to support clinical trials care. Speech changes one of the earliest most evident manifestations cerebellar ataxias. This work aims develop models that can accurately identify quantify signs ataxic speech. We use convolutional neural networks capture motor speech phenotype ataxia based on time frequency partial derivatives log-mel spectrogram representations train classification distinguish patients with from healthy...
Both individuals with diagnosed Autism Spectrum Disorder (ASD) and high in psychopathic traits show reduced susceptibility to contagious yawning; that is, yawning after seeing or hearing another person yawn. Yet it is unclear whether the same underlying processes (e.g., eye gaze) are responsible for relationship between contagion these very different types of clinical traits. College Students ( n = 97) watched videos scratching (a form not reliant on gaze transmission) while their movements...
Abstract Quantitative analysis of human behavior is critical for objective characterization neurological phenotypes, early detection neurodegenerative diseases, and development more sensitive measures disease progression to support clinical trials translation new therapies into practice. Sophisticated computational modeling can these objectives, but requires large, information-rich data sets. This work introduces Neurobooth, a customizable platform time-synchronized multimodal capture...
Objective, sensitive, and meaningful disease assessments are critical to support clinical trials care. Speech changes one of the earliest most evident manifestations cerebellar ataxias. The purpose this work is develop models that can accurately identify quantify these abnormalities.We use deep learning such as ResNet 18 , take time frequency partial derivatives log-mel spectrogram representations speech input, learn capture motor phenotype ataxia. We train classification separate patients...
To clarify the natural history of neurodegeneration related to a heterozygous missense de novo mutation in upstream binding transcription factor (UBTF) gene and understand movement patterns extracted from continuous wrist ankle accelerometer data.