A5059774215- Bone Metabolism and Diseases
- Thermal properties of materials
- Microbial Inactivation Methods
- Heat Transfer and Optimization
- Spaceflight effects on biology
- Bone health and osteoporosis research
- Graphene research and applications
- Nanopore and Nanochannel Transport Studies
- Bone Tissue Engineering Materials
- Bone health and treatments
- Gas Sensing Nanomaterials and Sensors
- Microfluidic and Bio-sensing Technologies
- Bone fractures and treatments
- 3D Printing in Biomedical Research
- Freezing and Crystallization Processes
- Ultrasound and Hyperthermia Applications
- Advanced MEMS and NEMS Technologies
- Thermal Radiation and Cooling Technologies
- Advanced Sensor Technologies Research
- Photoacoustic and Ultrasonic Imaging
- Cellular Mechanics and Interactions
- Heat Transfer and Boiling Studies
- nanoparticles nucleation surface interactions
- Adhesion, Friction, and Surface Interactions
- Advanced Chemical Sensor Technologies
Kyushu University
2013-2024
Juntendo University
2016
Tokyo Medical and Dental University
2010-2012
Kyushu Sangyo University
2004-2009
TDK (Japan)
2003
Regulation of irreversible cell lineage commitment depends on a delicate balance between positive and negative regulators, which comprise sophisticated network transcription factors. Receptor activator NF-kappaB ligand (RANKL) stimulates the differentiation bone-resorbing osteoclasts through induction nuclear factor activated T cells c1 (NFATc1), essential for osteoclastogenesis. Osteoclast-specific robust NFATc1 is achieved an autoamplification mechanism, in constantly by calcium signaling...
Abstract Utilizing nanomachining technologies, it is possible to manipulate the heat transport in graphene by introducing different defects. However, due difficulty suspending large-area single-layer (SLG) and limited temperature sensitivity of present probing methods, correlation between defects thermal conductivity SLG still unclear. In this work, we developed a new method for fabricating micro-sized suspended SLG. Subsequently, focused ion beam (FIB) was used create nanohole tune...
We measured both in-plane electrical and thermal properties of the same suspended monolayer graphene using a novel T-type sensor method. At room temperature, values are about 240 000 Ω−1 m−1 2100 W K−1 for conductivities, respectively. Based on Wiedemann-Franz law, electrons have negligible contribution to conductivity graphene, while LA TA modes phonons dominant heat carriers. In absence layer-layer layer-substrate interactions enhances long wave-length transport increases accordingly. The...
Irreversible electroporation (IRE) is attracting much attention as a less-invasive therapy to ablate abnormal tissues. With pair of electrodes inserted into the tissue, IRE perforates targeted cells non-thermally by train intensive electric pulses that exceeds certain threshold. Since only are necrotized percutaneously, extracellular matrix kept intact in IRE, which favorable for prompt tissue regeneration. In this study, we demonstrated also applicable treat superficial targets such...
Three-dimensional cell culture is widely used for challenging to biomedical tissue reconstruction. A mass of the reconstructed has been limited because difficulty in supplying sufficient amount oxygen deep into densely cultured cells. Although many methods are available oxygen, we focused on utilizing microbubbles. The aims present study were therefore develop a microbubble generator suitable culture, and examine its effects cellular activity. new was designed so that it could be autoclaved...
Influence of sample insertion holes in resonant cavity for a measuring fixture was investigated experimentally and numerically. Shift the frequency caused by loaded decreased when height or dielectric constant increased. Employing tall improved measurement error. Using commercial simulators, it found that disturbance electric field near hole deviation from ideally closed cavity. The simulation result inspected viewpoint physical rationality.
Osteocytes inside bone matrix play an important role in detecting the local mechanical environment. In order to study their responses, we have developed a loading device that can apply physiological and supraphysiological strains osteocytes embedded three dimensional (3-D) gel. The newly designed elastic chamber with ten separated culture wells simultaneously five different strain magnitudes for stretching of cells. When gel-embedded MLO-Y4 cells were prepared wells, they subjected levels 24...
Irreversible electroporation (IRE) is a new treatment to necrotize abnormal cells by high electric pulses. Electric potential difference over 1 V across the plasma membrane permanently permeabilizes cell with keeping extracellular matrix intact if thermal damage due Joule heating effect avoided. This largest advantage of IRE compared other conventional treatment. However, since has just started be used in clinical tests, it important predict necrotized region that depends on pulse parameters...
A new method is proposed to measure the longitudinal thermal conductivity of fibers and films. The novel one- two-dimensional materials has previously been measured using a T-type probe. Although this applicable polymer films, measurements are influenced by contact resistance between probe sample. We therefore propose so-called ITX method, which determines inherent sample from made in three geometric configurations ("I", "T", "X" shape) sample, heat sinks, measurement Application DNA solid...
The discovery of ultrafast water flow in graphene channels holds significant implications for a variety applications like electronics cooling, thermally driven energy harvesting, and solar-driven desalination. However, existing slip measurements on are confined to room temperature, limiting our understanding temperature-dependent behaviors constraining potential thermal applications. Here, we simultaneously measured lengths evaporation fluxes nanochannels with depths ranging from 78 290 nm,...