A5102773561- Genetic factors in colorectal cancer
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Plant and Fungal Interactions Research
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Digestive system and related health
- Colorectal Cancer Screening and Detection
- Protein Degradation and Inhibitors
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
Breast Cancer Now
2024
Institute of Cancer Research
2024
Karolinska Institutet
2019-2023
QIMR Berghofer Medical Research Institute
2010-2018
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that coordinates cell survival, inflammation, and immunogenic death (ICD). Although the catalytic function of RIPK1 is required to trigger death, its non-catalytic scaffold mediates strong pro-survival signaling. Accordingly, cancer cells can hijack block necroptosis evade immune detection. We generated small-molecule proteolysis-targeting chimera (PROTAC) selectively degraded human murine...
Research Article14 August 2018Open Access Source DataTransparent process CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer Murugan Kalimutho Corresponding Author [email protected] orcid.org/0000-0002-0772-8673 QIMR Berghofer Medical Institute, Herston, Qld, Australia School Natural Sciences, Griffith University, Nathan, Search for more papers by this author Debottam Sinha Jessie Jeffery Katia Nones Queensland Centre Genomics, Institute Molecular Bioscience, The...
Colorectal cancer is a major cause of death and approximately 20% arises within serrated polyps, which are under-recognized poorly understood. Human colorectal polyps frequently exhibit both oncogenic BRAF mutation widespread DNA methylation changes, important in silencing genes restraining neoplastic progression. Here, we investigated whether vivo induction mutant Braf sufficient to result coordinated promoter changes for multiple cancer-related genes. The BrafV637E was induced murine...
Cutaneous squamous cell carcinoma (cSCC) is one of the most common type cancer with metastatic potential. MicroRNAs (miRNAs) regulate gene expression at post-transcriptional level. Here, we report that miR-23b downregulated in cSCCs and actinic keratosis its regulated by MAPK signaling pathway. We show suppresses a network associated key oncogenic pathways miR-23b-gene signature enriched human cSCCs. MiR-23b decreased FGF2 both mRNA protein level impaired angiogenesis-inducing ability cells....
Abstract Defects in the number, structure, and function of centrosomes can generate mono- or multipolar mitotic spindles cytokinesis failure resulting aneuploidy chromosome instability, which are common characteristics tumour cells. Centrosomal proteins thus play central roles execution proper cell division. Cep55 is a centrosomal protein required for segregation two daughter cells during cytokinesis. It often elevated wide range cancer types including breast cancer. To ascertain functional...
Abstract Background. The majority of conventional colorectal adenomas are initiated by activation the Wnt signal, whilst MAPK pathway is associated with progression to cancer. In contrast, sessile serrated signaling due mutation BRAF oncogene, activated at transition dysplasia. We hypothesised that both and pathways play key roles in tumorigenesis, order which these would determine morphology lesion arising. Methods. To test this hypothesis, we utilised a conditional mutant mouse model...
Abstract Serrated polyps are now recognized as the precursor lesion from which sporadic BRAF (V600E) mutant/CIMP-H colorectal cancers (CRC) develop, but it appears likely mutation alone is not enough to drive progression carcinoma. CIMP generally localized proximal colon and may cause epigenetic silencing of key genes such IGFBP7 that act in concert with promote neoplasia. We conducting a detailed molecular analysis mechanism serrated neoplasia involving evasion oncogene-induced senescence...
Abstract The WNT and MAPK signaling pathways are central to colorectal homeostasis. Mutation of the APC tumor suppressor gene activates pathway initiate most conventional adenomas. By contrast, oncogenic BRAF mutation initiates development sessile serrated adenomas (SSA) via activation pathway. purpose this study was investigate frequency, timing mechanism in neoplasia. Methods: examined a range polyp cancer subtypes. Aberrant nuclear immuno-localization β-catenin used as surrogate for...