A5059896114- Drug Transport and Resistance Mechanisms
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Plant Molecular Biology Research
- Plant and animal studies
- Plant Parasitism and Resistance
- Trace Elements in Health
The University of Tokyo
2017-2018
HYPOSENSITIVE TO LIGHT (HTL) and DWARF14 (D14) mediate the perception of karrikin strigolactone, which stimulates germination parasitic weed Striga. However, their role in seeds is poorly understood, basis for differing responsiveness remains unclear. Here, we show that Striga hermonthica HTL proteins (ShHTLs) 'conserved' 'intermediate' clades are able to bind karrikin. The 'divergent' clade hydrolyze strigolactone. Unexpectedly, find ShD14 also capable hydrolyzing Through comparative...
Strigolactones (SLs) are a new class of phytohormones that also act as germination stimulants for root parasitic plants, such Striga spp., and branching factors symbiotic arbuscular mycorrhizal fungi. Sources natural SLs very limited. Hence, efficient simple SL analogs needed elucidating SL-related biological processes well agricultural applications. Based on the structure non-canonical methyl carlactonoate, we developed new, easy to synthesize series analogs, termed phenlactonoates (MPs),...
Apical sodium-dependent bile acid transporter (ASBT) retrieves acids from the small intestine and plays a pivotal role in enterohepatic circulation. Currently, high-resolution structures are available for two bacterial ASBT homologs (ASBT NM Neisseria meningitides Yf Yersinia frederiksenii ), which an elevator-style alternating-access mechanism has been proposed substrate transport. A key concept this model is that binds to central cavity of so elevator-like motion can expose bound...
Apical sodium-dependent bile acid transporter (ASBT) mediates the uptake of acids from ileum lumen into enterocytes and presents a potential target for treatment several metabolic diseases, including type 2 diabetes. It has been proposed that underlying mechanism transport by ASBT is an elevator-style alternating-access model, which was deduced mainly comparing high-resolution structures two bacterial homologs (ASBT NM Neisseria meningitides Yf Yersinia frederiksenii ) in different...