A5069102417- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Cassava research and cyanide
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Retinoids in leukemia and cellular processes
- Gestational Diabetes Research and Management
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Drug Transport and Resistance Mechanisms
- Folate and B Vitamins Research
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Effects and risks of endocrine disrupting chemicals
- Metabolism and Genetic Disorders
- Zebrafish Biomedical Research Applications
- Vitamin C and Antioxidants Research
- Eicosanoids and Hypertension Pharmacology
California Polytechnic State University
2017-2024
University of Illinois Urbana-Champaign
2023-2024
University of California, Davis
2012-2023
Western Human Nutrition Research Center
2012-2017
Agricultural Research Service
2012-2016
United States Department of Agriculture
2014
West Health
2013
Jean Mayer Human Nutrition Research Center on Aging
2013
Dichlorodiphenyltrichloroethane (DDT) has been used extensively to control malaria, typhus, body lice and bubonic plague worldwide, until countries began restricting its use in the 1970s. Its malaria continues some according recommendation by World Health Organization. Individuals exposed elevated levels of DDT metabolite dichlorodiphenyldichloroethylene (DDE) have an increased prevalence diabetes insulin resistance. Here we hypothesize that perinatal exposure disrupts metabolic programming...
Biofortification of cassava with the provitamin A carotenoid β-carotene is a potential mechanism for alleviating vitamin deficiency. Cassava staple food in African diet, but data regarding human bioavailability from this are scarce. The objective present study was to evaluate A-enhanced as source and healthy adult women. randomised, cross-over trial ten American subjects consumed three different porridges separated by 2 week washout periods. Treatment meals (containing 100 g cassava)...
Early time-restricted eating (eTRE) improves aspects of cardiometabolic health. Although the circadian system appears to regulate nutrient absorption, little is known about effects eTRE on intestinal absorption. In this randomized crossover trial, 16 healthy adults follow a controlled, weight maintenance diet for 9 days, consuming all calories between 0800 and 1400 (eTRE schedule) or 2000 (control schedule). We measure energy content diet, stool, urine with bomb calorimetry calculate The...
Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170 μg of TPhP maternal food from gestational day 8.5 to weaning evaluated metabolic phenotypes 3.5 month old male female rats, weight-matched males up 6 months, assess the development obesity type 2 diabetes mellitus (T2DM), respectively. Perinatal exposure increased body fat mass while leptin cumulative energy intake were elevated females, Independent mass,...
Pulmonary hypertension (PH) is a common consequence of bronchopulmonary dysplasia (BPD) and remains primary contributor to increased morbidity mortality among preterm infants. Unfortunately, at the present time, there are no reliable early predictive markers for BPD-associated PH. Considering its health consequences, understanding in utero perturbations that lead development BPD PH identifying utmost importance. As part discovery phase, we applied multiplatform metabolomics approach...
Abstract Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies shown or Geniposide can cause hepatotoxicity rats. We investigated Geniposide-induced hepatic injury male Sprague-Dawley rats after 3-day intragastric administration 100 mg/kg 300 Geniposide. Changes histomorphology, serum liver enzyme, and bile acid profiles, synthesis...
To investigate the role of bile acids (BAs) in pathogenesis diet-induced nonalcoholic steatohepatitis (NASH), we fed a "Western-style diet" [high fructose, high fat (HFF)] enriched with cholesterol, and saturated for 10 wk to juvenile Iberian pigs. We also supplemented probiotics vitro BA deconjugating activity evaluate their potential therapeutic effect NASH. Liver lipid function, cytokines, hormones were analyzed using commercially available kits. Metabolites, BAs, fatty measured by liquid...
Abstract Conversion of heterotrophic organisms into partially or completely autotrophic is primarily accomplished by extensive metabolic engineering and laboratory evolution efforts that channel CO 2 central carbon metabolism. Here, we develop a directed endosymbiosis approach to introduce assimilation in budding yeasts. Particularly, engineer assimilating sugar-secreting photosynthetic cyanobacterial endosymbionts within the yeast cells, which results generation yeast/cyanobacteria chimeras...
Inadequate vitamin and mineral intake is documented among individuals with obesity, but unknown long-term weight loss maintainers (WLM). This study examined dietary quality micronutrient adequacy WLMs in a commercial management program. Participants were 1207 WLM Weight Watchers (WW) who had maintained 9.1 kg or greater (29.7 on average) for 3.4 years body mass index (BMI) of 28.3 kg/m2. A control group stable adults obesity (controls; N = 102) BMI 41.1 Measures included the Diet History...
Gestational Diabetes Mellitus (GDM) results in complications affecting both mothers and their offspring. Metabolomic analysis across pregnancy provides an opportunity to better understand GDM pathophysiology. The objective was conduct a metabolomics of first third trimester plasma samples identify metabolic differences associated with development. Forty pregnant women overweight/obesity from multisite clinical trial lifestyle intervention were included. Participants who developed (n = 20;...
The objective of this study was to investigate whether juvenile Iberian pigs with diet-induced nonalcoholic fatty liver disease (NAFLD), cholestasis, and gut dysbiosis would develop histological metabolic markers neurodegeneration in the frontal cortex (FC) supplementing probiotics influence response diet. Twenty-eight were fed for 10 wk either a control (CON) or high-fructose high-fat (HFF) diet without commercial probiotic mixture. Compared CON, HFF-fed had decreased number neurons an...
Non-alcoholic fatty liver disease (NAFLD) is a serious metabolic condition affecting millions of people worldwide. A "Western-style diet" has been shown to induce pediatric NAFLD with the potential disruption skeletal muscle composition and metabolism. To determine in vivo effect on fiber type fuel utilization, 28 juvenile Iberian pigs were fed either control diet (CON) or high-fructose, high-fat (HFF), without probiotic supplementation, for 10 weeks. The HFF diets increased total...