A5070838276- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- Enzyme Structure and Function
- RNA regulation and disease
- HIV/AIDS drug development and treatment
- Membrane Separation Technologies
- Vector-borne infectious diseases
- Virus-based gene therapy research
- Toxin Mechanisms and Immunotoxins
- Biochemical effects in animals
- Glycosylation and Glycoproteins Research
- interferon and immune responses
Dartmouth College
2024
University of Maryland, Baltimore County
2020
Howard Hughes Medical Institute
2020
Centre de Recherches sur les Macromolécules Végétales
1974
Our current understanding of HSV latency is based on a variety clinical observations, and in vivo, ex vitro model systems, each with unique advantages drawbacks. The criteria for authentically modeling include the ability to easily manipulate host genetics biological pathways, as well mimicking immune response viral pathogenesis human infections. Although realistically necessary when choosing model, cost, time requirement, ethical constraints, reagent availability are also equally important....
Herpes simplex virus 1 (HSV-1) establishes latent infections in sensory neurons, from which HSV sporadically reactivates due to external stress and other stimuli. Latency reactivation are studied through vivo models a variety of hosts, as well vitro using primary neurons derived pluripotent stem cells (iPSCs). These systems behave disparately, but the reasons remain unknown. The interferon (IFN)-based neuronal innate immune response is critical controlling HSV-1 replication counters these...