A5100631144- Genetic and Kidney Cyst Diseases
- Vibration Control and Rheological Fluids
- Renal and related cancers
- Vibration and Dynamic Analysis
- Hedgehog Signaling Pathway Studies
- Structural Engineering and Vibration Analysis
- Caveolin-1 and cellular processes
- Numerical methods in engineering
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Virus-based gene therapy research
- Thermoelastic and Magnetoelastic Phenomena
- Microtubule and mitosis dynamics
- Fluid Dynamics and Vibration Analysis
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Composite Structure Analysis and Optimization
Harbin Institute of Technology
2010-2023
Cornell University
2008-2018
The primary cilium is a microtubule-based organelle that protrudes from the cell surface and plays essential roles in embryonic development. Ciliogenesis begins with successive fusion of preciliary vesicles to form ciliary vesicles, which then dock onto distal end mother centriole. Rab proteins have been linked cilia formation cultured cells, but not yet vivo In present study, we demonstrate endocytic recycling protein Rab34 localizes cilia, its mutation results significant decrease...
Dynamic performance of sandwich beam with shear thickening fluid (STF) core subjected to a periodic excitation is investigated. The addition STF enables the have tuning stiffness and damping capacity under dynamic deformation. Here, constitutive model described by complex modulus related rate. transverse moving modeled based on Newtonian law derived nonlinear equations are solved finite difference method. It found that resonant frequency increases amplitude external power law. In addition,...
AbstractThe dynamic performances of a sandwich beam with shear thickening fluid (STF) core subjected to random excitation are investigated. First, the STF is prepared and new constitutive model proposed based on oscillatory rheological measurements. Next, flexural vibration an under load developed, parametric study carried out. It found that response frequencies damping ratios for first three modes increase standard deviation external excitation. The provides better larger broadband...
Meckel-Gruber syndrome (MKS) is a recessive disorder resulting in multiple birth defects that are associated with mutations affecting ciliogenesis. We recovered mouse mutant mutation the Mks1 gene (Mks1(del64-323)) caused 260-amino-acid deletion spanning nine amino acids B9 domain, protein motif unknown function conserved two other basal body proteins. showed that, wild-type cells, was localized to mother centriole from which cilium generated. However, Mks1(del64-323) not centriole, even...