A5022815323- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Child Development and Digital Technology
- Child Nutrition and Feeding Issues
- Autism Spectrum Disorder Research
- Circadian rhythm and melatonin
- Plant Molecular Biology Research
- Vasculitis and related conditions
- Adipose Tissue and Metabolism
- Mechanical Engineering and Vibrations Research
- Diet and metabolism studies
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Silk-based biomaterials and applications
Seattle Children's Hospital
2024
University of Washington
2024
Georgia Highlands College
2018-2024
Washington State University
2024
Washington State University Spokane
2018-2022
Autism Spectrum Disorder (ASD) is the most prevalent neurodevelopmental disorder in United States and often co-presents with sleep problems. Sleep problems ASD predict severity of core diagnostic symptoms have a considerable impact on quality life caregivers. Little known, however, about underlying molecular mechanisms ASD. We investigated role Shank3, high confidence gene candidate, architecture regulation. show that mice lacking exon 21 Shank3 falling asleep even when sleepy. Using RNA-seq...
Abstract Sleep problems are prevalent in autism spectrum disorder (ASD), can be observed before diagnosis, and associated with increased restricted repetitive behaviors. Therefore, sleep abnormalities may a core feature of the disorder, but developmental trajectory remains unknown. Animal models provide unique opportunity to understand ontogenesis ASD. Previously we showed that adult mice truncation high‐confidence ASD gene Shank3 (Shank3 ∆C ) recapitulate clinical phenotype. In this study...
We present the case of an acute onset ANCA positive vasculitis in asymptomatic COVID-19 infected teenager, resulting significant colonic damage. The patient was initially diagnosed with Henoch-Schönlein purpura and presented worsening symptoms necrosis her perineum rectum requiring surgical debridement diverting colostomy. As a part work-up, she tested for total IgG/IgM antibodies antibodies. This complements previously reported cases induced autoimmune disease children but is novel...
ABSTRACT Sleep problems are prevalent in Autism Spectrum Disorder (ASD), can be observed before diagnosis, and associated with increased restricted repetitive behaviors. Therefore, sleep abnormalities may a core feature of the disorder, but developmental trajectory remains unknown. Animal models provide unique opportunity to understand ontogenesis ASD. Previously we showed that adult mice truncation high-confidence ASD gene Shank3 (Shank3 ΔC ) recapitulate clinical phenotype. In this study...
Abstract Introduction Insomnia, characterized by problems falling asleep, less sleep, and a lower quality is more prevalent among individuals with autism spectrum disorders (ASD) compared to typical development. Insomnia in ASD predicts severity of symptoms impacts life, however the mechanisms linking poor sleep are not well understood. Genetic mouse models have been essential understanding ASD. We previously showed that mice deletion exon 21 Shank3 (Shank3ΔC), high confidence gene,...
Abstract Sleep is an essential, tightly regulated biological function. also a homeostatic process, with the need to sleep increasing as function of being awake. Acute deprivation (SD) increases need, and subsequent recovery (RS) discharges it. SD known alter brain gene expression in rodents, but it remains unclear which changes are linked homeostasis, SD-related impairments, or non-sleep-specific effects. To investigate this question, we analyzed RNA-seq data from adult wild-type male mice...
Abstract Autism Spectrum Disorder (ASD) is the most prevalent neurodevelopmental disorder in United States and often co-presents with sleep problems. Sleep problems ASD predict severity of core diagnostic symptoms have a considerable impact on quality life caregivers. Little known, however, about underlying molecular mechanisms. We investigated role Shank3 , high confidence gene candidate, architecture regulation. show that mice lacking exon 21 falling asleep even when sleepy. Using RNA-seq...