A5067392084- Gear and Bearing Dynamics Analysis
- Mechanical stress and fatigue analysis
- Adhesion, Friction, and Surface Interactions
- Genomics and Rare Diseases
- Contact Mechanics and Variational Inequalities
- Tribology and Lubrication Engineering
- Railway Engineering and Dynamics
- Genetic Syndromes and Imprinting
- Advanced machining processes and optimization
- Metabolism and Genetic Disorders
- Neurogenetic and Muscular Disorders Research
- Dynamics and Control of Mechanical Systems
- Telomeres, Telomerase, and Senescence
- Muscle Physiology and Disorders
- Prenatal Screening and Diagnostics
- Occupational Health and Safety Research
- Per- and polyfluoroalkyl substances research
- Advanced Chemical Sensor Technologies
- Toxic Organic Pollutants Impact
- Neurotransmitter Receptor Influence on Behavior
- Marine and Coastal Research
- Effects and risks of endocrine disrupting chemicals
- Environmental Impact and Sustainability
- Icing and De-icing Technologies
- Non-Destructive Testing Techniques
Southwest Research Institute
2019-2024
American College of Medical Genetics
2020-2022
Research Network (United States)
2022
Intel (United States)
2021
Torrington Hospital
1976-1987
Abstract The Human Phenotype Ontology (HPO, https://hpo.jax.org) was launched in 2008 to provide a comprehensive logical standard describe and computationally analyze phenotypic abnormalities found human disease. HPO is now worldwide for phenotype exchange. has grown steadily since its inception due considerable contributions from clinical experts researchers diverse range of disciplines. Here, we present recent major extensions the neurology, nephrology, immunology, pulmonology, newborn...
A numerical solution is presented which can be used to analyze the complete range of frictionless contact problems found in rolling element bearings. three dimensional, linear elastic problem developed by combining Boussinesq force-displacement relationships for a half-space with modified flexibility method. In this manner stable system algebraic equations terms unknown surface pressures formed, no restrictions placed upon either symmetry or material connectivity. Several examples common but...
Advancements in therapies for Duchenne muscular dystrophy (DMD) have made diagnosis within the newborn period a high priority. We undertook consortia approach to advance DMD screening United States. This manuscript describes formation of Newborn Screening Consortium, development pilot protocols, data collection tools including parent surveys, and findings from first year two-year pilot. The design is population-based recruitment infants born New York State. Data were developed document...
Abstract Despite their effectiveness in modeling complex phenomena, the adoption of machine learning (ML) methods computational mechanics has been hindered by lack availability training datasets, limitations on accuracy out-of-sample predictions, and cost. This work presents a physics-informed ML approach network architecture that addresses these challenges context behavior materials with damage. The proposed methodology is novel general convolutional (PIGCN) framework features (1) fusion...
Presented herein is a method of solution for three dimensional counterformal contact problems involving layered solids. Based on the generalized Boussinesq half space, displacement and stress coefficients are formulated uniformly distributed load applied over rectangular area surface space. A precise analytical has been developed to find pressure, area, approach subsurface stresses arbitrary shapes. Numerical results have obtained indentation second order with solid case layer substrate...
The goal of newborn screening is to improve health outcomes by identifying and treating affected newborns. This manuscript provides an overview a data tool facilitate the longitudinal collection information on newborns diagnosed with condition through NBS. Newborn Screening Translational Research Network (NBSTRN) developed Longitudinal Pediatric Data Resource (LPDR) capture, store, analyze, visualize, share genomic phenotypic over lifespan NBS identified understanding genetic disease assess...
Masks constructed of a variety materials are in widespread use due to the COVID-19 pandemic, and people exposed chemicals inherent masks through inhalation. This work aims survey commonly available mask provide an overview potential exposure. A total 19 were analyzed using nontargeted analysis two-dimensional gas chromatography (GCxGC)–mass spectrometric (MS) workflow. Traditionally, there has been lack GCxGC–MS automated high-throughput screening methods, resulting trade-offs with...
Presented here is a method of solution for three-dimensional contact involving cylindrical bodies without using the half-space assumption. The involves numerical iterative technique to determine pressure in various cells discretizing prescribed area on surface, sufficiently large cover contact. iteration carried out flexibility matrix which radial deflections at cell centers due uniformly distributed unit load acting small surfaces. Numerical results have been obtained (1) closely conformed...
The purpose of the paper has been to present a comparison theoretically predicted and experimentally measured pressures between nearly cylindrical rollers. primary theoretical experimental tools have described earlier, but required some refinement evaluate critical edge stress conditions. At misalignment levels on order 0.86 1.25 × 10−3 radians, stresses 2 GPa predicted. These are more than twice that would occur for ideal line contact.
The goal of newborn screening is to improve health outcomes by identifying and treating affected newborns. This manuscript provides an overview a data tool facilitate the longitudinal collection information on newborns diagnosed with condition through NBS. Newborn Screening Translational Research Network (NBSTRN) developed Longitudinal Pediatric Data Resource (LPDR) capture, store, analyze, visualize, share genomic phenotypic over lifespan NBS identified understanding genetic disease, assess...
This work demonstrates high-throughput screening of personal care products to provide an overview potential exposure. Sixty-seven from five categories (body/fragrance oil, cleaning product, hair care, hand/body wash, lotion, sunscreen) were rapidly extracted and then analyzed using suspect by two-dimensional gas chromatography (GCxGC) high-resolution mass spectrometry (GCxGC-HRT). Initial peak finding integration performed commercial software, followed batch processing the machine learning...
With the rapid increase in publicly available sequencing data, healthcare professionals are tasked with understanding how genetic variation informs diagnosis and affects patient health outcomes. Understanding impact of a variant disease could be used to predict susceptibility/protection help build personalized medicine profile. In United States, over 3.8 million newborns screened for several rare diseases each year, follow-up testing screen-positive often involves identification variants....
The purpose of the paper has been to present a comparison theoretical predictions and experimental data for contact stresses between two bodies lubricated in contact. analysis is based on three-dimensional linear elastic solution problem combines Boussinesq force-displacement relationships half-space with modified flexibility method. approach involves direct measurement pressures profiled rollers using thin-film pressure transducer. Pressure measurements were made three roller designs under...
Characterization of chemicals in household products is important for understanding this potential source chemical exposure. Increasingly, suspect screening and nontargeted analysis techniques are used to characterize as many signatures possible. Solids such most conveniently prepared using solvent extraction, revealing what contained within the product matrix but providing no information about those leave cause actual In work, profile relative abundances "extractable" found after extraction...
Abstract This work examines data from a multi-year, large deployment of corrosion sensors in variety locations representing range corrosivity severities. The used this measure atmospheric parameters including relative humidity and temperature addition to conductance the electrolyte formed by salt deposition. First, rudimentary model is developed based on small sampling sites demonstrate means which environmental (RH, temperature, conductance) can be viewed assess severity. simplified applied...
Depths of permanent deformation, resulting from the heavily stressed contact a cylindrical roller on bearing raceway surface, are evaluated by employing an analytical treatment elasto-plastic bodies in line contact. Constitutive relations, that analysis obtained incremental theory plasticity conjunction with respective von Mises and Tresca yield criterion applicable to isotropic problems plane stress or strain, advanced. The significance elastic strains problem, as well work hardening...
Presented herein is a design model which may be employed to estimate the life of nonuniformly supported surface acted upon by translating cylinder when latter subjected periodic loadings. The Lundberg-Palmgren theory contact fatigue in conjunction with modified finite element method thereby allowing prediction for roller track system. First, advanced using analysis technique pressure resulting from and nonuniform back-up supports determined, next, basic dynamic capacity rating system,...