A5003649591- Inflammatory Bowel Disease
- NF-κB Signaling Pathways
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
- Helicobacter pylori-related gastroenterology studies
- Digital Mental Health Interventions
- Mental Health Research Topics
- COVID-19 Digital Contact Tracing
- COVID-19 and Mental Health
- Immune Response and Inflammation
- Respiratory viral infections research
- Otolaryngology and Infectious Diseases
- Influenza Virus Research Studies
- Data-Driven Disease Surveillance
- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Bacterial Identification and Susceptibility Testing
- Biomedical Text Mining and Ontologies
- Rabies epidemiology and control
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Mobile Health and mHealth Applications
- Mental Health via Writing
- Genomics, phytochemicals, and oxidative stress
LifeGlimmer (Germany)
2017-2022
Inserm
2019
Centre International de Recherche en Infectiologie
2019
Université Claude Bernard Lyon 1
2019
École Normale Supérieure de Lyon
2019
Centre National de la Recherche Scientifique
2019
Hospices Civils de Lyon
2019
Abstract Background Necrotizing soft-tissue infections (NSTI) are life-threatening conditions often caused by β-hemolytic streptococci, group A Streptococcus (GAS) in particular. Optimal treatment is contentious. The INFECT cohort includes the largest set of prospectively enrolled streptococcal NSTI cases to date. Methods From 409 adults admitted with 5 clinical centers Scandinavia, patients culture-positive for GAS or dysgalactiae (SD) were selected. Risk factors identified comparison a...
The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using lentivirus approach, NF-κB-regulated luciferase was expressed patient macrophages, isolated from frozen peripheral blood mononuclear cell samples. Following activation, samples could be segregated into three clusters based on response. ulcerative colitis (UC) appeared...
Real-life data on long-term disease activity in Crohn's [CD] are scarce. Most studies describe course by using proxies, such as drug exposure, need for surgery or hospitalisations, and progression. We aimed to identify distinctive patterns the population-based IBD South Limburg cohort [IBDSL].All CD patients IBDSL with ≥10 years follow-up [n = 432] were included. Disease was defined each yearly quarter mucosal inflammation endoscopy imaging, hospitalisation, surgery, treatment adjustment...
<title>Abstract</title> High maternal mortality rates persist as a critical challenge in low-resource settings. This study investigates whether integrating Clinical AI (cAI) designed for symptom assessment (Ada) into Whatsapp-based government platform (MomConnect) enhances self-care and health-seeking decision-making among pregnant women mothers. From May to June 2023, mixed-methods enrolled participants. A baseline survey captured initial care-seeking intentions, followed by cAI use...
Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has major protective role in the intestine. Although its production by cells of innate and adaptive immune system been extensively studied, intrinsic intestinal epithelial poorly understood. In this study, we utilised both ATAC sequencing RNA to define transcriptional response murine enteroids tumour necrosis factor (TNF). We identified key early phase drivers TNF within epithelium were NF κ B transcription dependent....
Background The INFECT project aims to advance our understanding of the pathophysiological mechanisms in necrotizing soft tissue infections ( NSTI s). observational study is part with aim studying clinical profile patients s and correlating these patient‐important outcomes. With this protocol statistical analysis plan we describe methods used obtain data details planned analyses. Methods a multicentre, prospective cohort study. Patients are enrolled five Scandinavian hospitals, which all...
Background Unprecedented lockdown measures have been introduced in countries worldwide to mitigate the spread and consequences of COVID-19. Although attention has focused on effects these epidemiological indicators relating directly infection, there is increased recognition their broader health implications. However, assessing implications real time a challenge, due limitations existing syndromic surveillance data tools. Objective The aim this study explore added value mobile phone app–based...
Abstract Analyses of plasma collected pre- and postadministration intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose toxin-triggered T-cell proliferation (r = −.67, P &lt; .0001). One 25-g was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT 01790698 NCT02111161.
ABSTRACT Inflammatory bowel diseases (IBDs) cause significant morbidity and mortality. Aberrant NF-κB signalling is strongly associated with these conditions, several established drugs influence the network to exert their effect. This study aimed identify that alter could be repositioned for use in IBD. The SysmedIBD Consortium a novel drug-repurposing pipeline based on combination of silico drug discovery biological assays targeted at demonstrating an impact signalling, murine model...
Necrotizing soft tissue infections (NSTIs) caused by group A Streptococcus (GAS) and occasionally Staphylococcus aureus (SA) frequently involve the deep fascia often lead to muscle necrosis.To assess pathogenicity of GAS S. for muscles in comparison keratinocytes, adhesion invasion NSTI-GAS NSTI-SA isolates were assessed these cells. Bloodstream (BSI-SA) noninvasive coagulase-negative staphylococci (CNS) used as controls.NSTI-SA BSI-SA exhibited stronger internalization into human...
Background Participatory epidemiology is an emerging field harnessing consumer data entries of symptoms. The free app Ada allows users to enter the symptoms they are experiencing and applies a probabilistic reasoning model provide list possible causes for these Objective objective our study explore potential contribution syndromic surveillance by comparing influenza-like illness (ILI) entered in Germany with from national population-based reporting system called GrippeWeb. Methods We...
Background Necrotizing soft tissue infections ( NSTI s) are rare but carry a high morbidity and mortality. The multicenter INFECT project aims to improve the understanding of pathogenesis, clinical characteristics, diagnosis, prognosis s. This article describes study outline statistical analyses that will be used. Methods Within framework project, patients with at 5 Scandinavian hospitals enrolled in prospective observational cohort study. goal is evaluate outcome characteristics for...
Representative studies concerning the long-term prognosis and disease course in Crohn’s (CD) primarily describe steroid exposure, need for surgery or hospitalisations, progression as characteristics of an unfavourable outcome. Real-life data on activity are lacking. We aimed to define clusters with different patterns population-based IBDSL cohort. All CD patients from cohort at least 10 years follow-up (>18 years, diagnosed between 1991 2004) were included. Data demographics, phenotype,...
Abstract Objective Inflammatory bowel diseases cause significant morbidity and mortality. Aberrant NF-κB signalling is strongly associated with these conditions, several established drugs influence the network to exert their effect. This study aimed identify which alter may be repositioned for use in inflammatory disease. Design The SysmedIBD consortium a novel drug-repurposing pipeline based on combination of in-silico drug discovery biological assays targeted at demonstrating an impact...
<sec> <title>BACKGROUND</title> Unprecedented lockdown measures have been introduced in countries worldwide to mitigate the spread and consequences of COVID-19. Although attention has focused on effects these epidemiological indicators relating directly infection, there is increased recognition their broader health implications. However, assessing implications real time a challenge, due limitations existing syndromic surveillance data tools. </sec> <title>OBJECTIVE</title> The aim this study...
Background: Inflammatory bowel diseases (IBD) are characterized by a chronic inflammation of the gastrointestinal tract. The course is variable, ranging from quiescent to multiple (severe) flares, often necessitating surgery. Early identification patients with an expected poor prognosis may be importance, adapt treatment strategies accordingly. Currently used clinical markers for severe disease have limited value decision making in daily practice. Although diagnostic medical reports, e.g....
Abstract Background Unprecedented lockdown measures have been introduced in countries across the world to mitigate spread and consequences of COVID-19. While attention has focused on effects these epidemiological indicators relating directly infection, there is increased recognition their broader health implications. However, assessing implications real time a challenge, due limitations existing syndromic surveillance data tools. Objective To explore added value mobile phone app-based...
Abstract The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation the NF-κB transcription factor is a highly-regulated, dynamic event in IBD pathogenesis. We expressed human NF-κB/p65 subunit blood-derived macrophages, using lentivirus. Confocal imaging p65 activation revealed that higher proportion macrophages from Crohn’s patients responded to lipid-A compared controls. In contrast, cells ulcerative colitis (UC)...
The NFκB transcription factors are major regulators of innate immune responses, and signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκBα-eGFP transgenic strain study functional implication xenogeneic (human) RelA(p65) protein introduced into mouse genome. Confocal imaging showed that human RelA expressed in cells can translocate nucleus following activation Toll-like receptor 4. RNA sequencing lipid...
<sec> <title>BACKGROUND</title> Participatory epidemiology is an emerging field harnessing consumer data entries of symptoms. The free app Ada allows users to enter the symptoms they are experiencing and applies a probabilistic reasoning model provide list possible causes for these </sec> <title>OBJECTIVE</title> objective our study explore potential contribution syndromic surveillance by comparing <i>influenza-like illness</i> (ILI) entered in Germany with from national...
<sec> <title>BACKGROUND</title> Mental health conditions pose a significant challenge for healthcare systems globally, and digital solutions have been proposed to address the challenges of limited access healthcare, stigmatization, lack reliable data. An understanding potential risk factors, comorbidities, symptom constellations forms necessary foundation future with diagnostic capabilities. Currently used products such as checkers generate novel data sets that could provide insight into...
The global spread of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARSCoV2) has led to pandemic outbreak disease 2019 (COVID19), an inflammatory that is primarily affecting system. However, gastrointestinal symptoms in COVID19 patients suggests gut may present another viral target organ. Disease development and severity dependent on interaction with two cell surface human proteins, ACE2 TMPRSS2, antiviral response which lead systemic hyperinflammatory multiorgan...