A5062766129- Virus-based gene therapy research
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Plant Virus Research Studies
- RNA Research and Splicing
- RNA modifications and cancer
- HIV Research and Treatment
- Alkaline Phosphatase Research Studies
- Respiratory viral infections research
- Biochemical and Molecular Research
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
Boston University
2023-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2021
Institut Pasteur
2015
Institut de Virologie
2015
Centre National de la Recherche Scientifique
2015
Abstract The transcription and replication processes of non-segmented, negative-strand RNA viruses (nsNSVs) are catalyzed by a multi-functional polymerase complex composed the large protein (L) cofactor protein, such as phosphoprotein (P). Previous studies have shown that nsNSV can adopt dimeric form, however, structure dimer its function poorly understood. Here we determine 2.7 Å cryo-EM human parainfluenza virus type 3 (hPIV3) L–P with connector domain (CD′) second L built, while...
Presently, respiratory syncytial virus (RSV), the main cause of severe infections in infants, cannot be treated efficiently with antivirals. However, its RNA-dependent polymerase complex offers potential targets for RSV-specific drugs. This includes recognition template, ribonucleoprotein (RNP), consisting genomic RNA encapsidated by RSV nucleoprotein, N. proceeds via interaction between phosphoprotein P, which is cofactor, and The determinant role C terminus more particularly last residue,...
A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules. These phase-separated molecular ‘sponges’, stabilized quinary (transient weak) interactions, control proteins involved in numerous biological functions. Retroviruses such as HIV-1 form self-assembly when their genomic RNA (gRNA) traps Gag GagPol polyprotein precursors. Infectivity requires extracellular budding the particle followed...
Abstract A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules. These phase separated molecular ‘sponges’, stabilized quinary (transient weak) interactions, control proteins involved in numerous biological functions. Retroviruses such as HIV-1 form self-assembly when their genomic RNA (gRNA) traps Gag GagPol polyprotein precursors. Infectivity requires extracellular budding the particle followed...