A5039597643- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Marine Bivalve and Aquaculture Studies
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Environmental and Agricultural Sciences
- Cholinesterase and Neurodegenerative Diseases
- Forest, Soil, and Plant Ecology in China
- Land Use and Ecosystem Services
- Ecosystem dynamics and resilience
- Remote Sensing and Land Use
- Environmental Quality and Pollution
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Environmental Changes in China
- Sustainable Industrial Ecology
- Neonatal and fetal brain pathology
Mila - Quebec Artificial Intelligence Institute
2023-2024
Massachusetts Institute of Technology
2015-2021
Nanjing University
2014
Shanghai Ocean University
2010
The memory for a new episode is formed immediately upon experience and can last up to lifetime. It has been shown that the hippocampal network plays fundamental role in rapid acquisition of one-time experience, which novelty component promotes prompt formation memory. However, it remains unclear neural circuits convey signal hippocampus single-trial learning. Here, we show during encoding neuromodulatory input from locus coeruleus (LC) CA3, but not CA1 or dentate gyrus, necessary facilitate...
Experiences need to be tagged during learning for further consolidation. However, neurophysiological mechanisms that select experiences lasting memory are not known. By combining large-scale neural recordings in mice with dimensionality reduction techniques, we observed successive maze traversals were tracked by continuously drifting populations of neurons, providing neuronal signatures both places visited and events encountered. When the brain state changed reward consumption, sharp wave...
Significance The importance of entorhinal–hippocampal circuits in the mammalian brain for an animal’s spatial and episodic experience is known, but neural basis these different computations unclear. Medial entorhinal cortex layer II contains island ocean cells that project via separate pathways into hippocampus. We performed Ca 2+ imaging freely exploring mice using cellular markers a miniature head-mounted fluorescence microscope, first time (to our knowledge) cortex. found that, although...
A general wisdom is that experiences need to be tagged during learning for further consolidation. However, brain mechanisms select lasting memory are not known. Combining large-scale neural recordings with a novel application of dimensionality reduction techniques, we observed successive traversals in the maze were tracked by continuously drifting populations neurons, providing neuronal signatures both places visited and events encountered (trial number). When state changed reward...
ABSTRACT A prevailing view is that the brain represents episodic experience as continuous moment to changes in experience. Whether also same a sequence of discretely segmented events, unknown. Here, we report hippocampal CA1 “chunking code”, tracking an episode its discrete event subdivisions (“chunks”) and sequential relationships between them. The chunking code unaffected by unpredicted variations within reflecting code’s flexible nature being organized around events abstract units....
The brain codes continuous spatial, temporal, and sensory changes in daily experience. Recent studies suggest that the also tracks experience as segmented subdivisions (events), but neural basis for encoding of events remains unclear. We designed a maze mice composed 4 materially indistinguishable lap events, report hippocampal CA1 neurons whose activity is modulated by number. This lap-specific ‘chunk code’ separate from spatial code. chunk code even when length unpredictably altered within...