A5053802073- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Pregnancy-related medical research
- Medical Imaging and Analysis
- Veterinary Orthopedics and Neurology
- Scoliosis diagnosis and treatment
- Corneal surgery and disorders
- Cancer Immunotherapy and Biomarkers
- Diabetic Foot Ulcer Assessment and Management
- CAR-T cell therapy research
- Corneal Surgery and Treatments
- Plant Toxicity and Pharmacological Properties
- Immunotherapy and Immune Responses
University of Pittsburgh
2016-2020
Abstract Rationale Age‐related changes in the intervertebral discs are predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, process wherein cells undergo growth arrest chronically secrete numerous inflammatory molecules proteases, has been reported cause decline health function of multiple tissues with age. Although senescent have increase degeneration (IDD), it is not known whether they causative age‐related...
We have previously reported that direct injection of dendritic cells (DC) engineered to express the Type-1 transactivator Tbet (i.e., DC.Tbet) into murine tumors results in antitumor efficacy association with development structures resembling tertiary lymphoid organs (TLO) tumor microenvironment (TME). These TLO contained robust infiltrates B cells, DC, NK and T proximity PNAd+ blood vessels; however, they were considered incomplete, since recruited failed organize classic germinal...
Whether disc aging is influenced by factors beyond its local environment an important unresolved question.Here we performed heterochronic parabiosis in mice to study the effects of circulating young and old blood on age-associated intervertebral degeneration.Compared isochronic pairs (Y-Y), paired with (Y-O) showed significant increases levels MMP-13 ADAMTS4, aggrecan fragmentation, histologic tissue degeneration, but negligible changes cellular senescence markers (p16 INK4a , p21 Cip1...