Aldosterone increases tubular Na(+) absorption largely by increasing α-epithelial channel (αENaC) transcription in collecting duct principal cells. How aldosterone reprograms basal αENaC to high-level activity the is incompletely understood. Promoter methylation, a covalent but reversible epigenetic process, has been implicated control of gene expression health and disease. We investigated role promoter methylation/demethylation aldosterone-stimulated mIMCD3 Bisulfite treatment sequencing...

The epithelial Na(+) channel subunit-α (αENaC) of the distal nephron is essential for salt balance. We previously demonstrated that histone methyltransferase Dot1a and its protein partner Af9 basally repress αENaC transcription in mouse inner medullary collecting duct type 3 (mIMCD3) cells link aldosterone-elicited chromatin modifications to transcriptional activation. DNA-binding activity has never been demonstrated, whether where binds promoter target are unknown. present study sought...

Abstract Due to the heavy workload of RSS collection, instability WLAN signal strength and disappearance signals caused by complex indoor environments, construction radio map for wireless local area network (WLAN) fingerprint-based positioning system is time-consuming laborious. In order rapidly deploy system, bidirectional encoder representation from transformers (BERT) model used fill missing in quickly build map. The imported into BERT form natural language text, filled model. Since...

Connective tissue growth factor (CTGF) participates in diverse fibrotic processes including glomerulosclerosis. The adenylyl cyclase agonist forskolin inhibits CTGF expression mesangial cells by unclear mechanisms. We recently reported that the histone H3K79 methyltransferase disruptor of telomeric silencing-1 (Dot1) suppresses gene collecting duct (J Clin Invest 117: 773-783, 2007) and HEK 293 Biol Chem In press). present study, we characterized involvement Dot1 mediating inhibitory effect...

As one of the most important micronutrients, iron (Fe) plays a critical role in various metabolic processes during plant growth and development. However, molecular mechanisms towards Fe metabolism nutrition fruit trees are largely unknown. In this study, we examined effects amino acid-Fe compound fertilizer spraying on leaf development peach ( Prunus persica (L.) Batsch) at different developmental stages. Foliar with did not cause any significant changes morphology but remarkably increased...

With the development of information technology, indoor positioning technology has been rapidly evolving. Due to advantages high accuracy, low cost, and wide coverage simultaneously, received signal strength‐ (RSS‐) based WLAN become one mainstream technologies. A radio map is basis for realization system. However, by reasons huge workload RSS collection, instability wireless strength, disappearance signals caused occlusion people objects, construction a time‐consuming inefficient. In order...

The epithelial Na+ channel (ENaC) in the distal nephron constitutes rate-limiting step for renal sodium reabsorption. Aldosterone increases tubular absorption large part by increasing αENaC transcription collecting duct principal cells. We previously reported that Af9 binds to +78/+92 of and recruits Dot1a repress basal aldosterone-sensitive mouse inner medullary (mIMCD)3 Despite this epigenetic repression, is still evident physiologically necessary, indicating operation positive regulators....

The physical and functional interaction of Rnf2 (RING finger protein 2), a central component the PRC (Polycomb repressive complex) 1 Af9 (ALL1-fused gene from chromosome 9 protein), an aldosterone-sensitive transcription factor, in regulating basal aldosterone-stimulated α-ENaC (epithelial Na+ channel α-subunit) was explored mIMCD3 CD (collecting duct) cells. Since lacks DNA-specific binding activity, other factors must mediate its site-specific chromatin recruitment. co-localized nucleus...

Design a shunt active power filter (SAPF) based on average algorithm (APA) and recursive least squares (RLS) self-adapting algorithm. Its reference current is balanced three-phase which has the same phase with voltage of system source. There are two parts including in value. One instantaneous should give to load APA. The other that calculated mainly by RLS Algorithm SAPF maintain DC-bus invariable. Combine these get final Controlled PWM pulse comparing between compensating real generating...

When training a stereo matching network with single dataset, the may overly rely on learned features of dataset due to differences in scenes, resulting poor performance all datasets. Therefore, feature consistency between matched pixels is key factor solving network’s generalization ability. To address this issue, paper proposed more widely applicable that introduced whitening loss into extraction module matching, and significantly improved applicability model by constraining variation...

SQL Injection Attack (SQLIA) is one of the main attack vectors against databases, which exploits a vulnerability that user-input data executed in database to maliciously concatenate query statements for purpose illegally querying database, posing significant threat web security. Due fact there are many similarities between injection and normal HTTP requests terms numerous identical fields, directly matching keywords by computers can result considerable amount misjudgment missed judgments....

In the field of indoor Wi-Fi localization, Received Signal Strength (RSS) is commonly used for positioning. However, it limited by low sampling density and signal instability. To address this issue, study introduces an innovative localization approach applying Bidirectional Encoder Representation from Transformers (BERT) to We propose a data recovery strategy that significantly improves positioning accuracy while requiring only small number samples construct complete wireless map....

The purpose of low-light image enhancement is to improve the clarity objects in environments facilitate recognition and detection targets later. Local Contrast Denoising Fusion Network (LCDFN) constructed address problem poor contrast severe noise low light images. Images obtained have as a whole, but usually some edge regions larger due presence source, processing images often results over-enhancement region, generating noise. In order suppress noise, firstly, determines region with by...

Abstract Due to the heavy workload of RSS collection, instability WLAN signal strength and disappearance signals caused by complex indoor environments, construction Radio Map for Wireless local area network (WLAN) fingerprint-based positioning system is time-consuming laborious. In order rapidly deploy system, Bidirectional Encoder Representation from Transformers (BERT) model used fill missing in quickly build Map. The imported into BERT form natural language text, filled model. Since...

Feature extraction is a crucial part of the stereo matching algorithm based on deep learning. The existing algorithms have poor effects smaller objects in background and low-texture areas, which leads to decrease disparity estimation accuracy. To improve accuracy estimates, we propose TUNet, Transformer-based iterative update network this paper. After feature module, attention mechanism positional encoding Transformer are added network, enables transformed features better combine global...

Abstract Extracting traffic information from images plays an important role in Internet of Vehicle (IoV). However, due to the high-speed movement and bumpiness vehicle, motion blur will occur image acquisition. In addition, rainy days, because rain is attached lens, target be blocked by rain, distorted. These problems have caused great obstacles for extracting key transportation images, which affect real-time judgment vehicle control system on road conditions, further cause decision-making...