A5005719758- Bone and Joint Diseases
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Total Knee Arthroplasty Outcomes
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Neurogenesis and neuroplasticity mechanisms
- Lower Extremity Biomechanics and Pathologies
- Bone health and treatments
- Laser Applications in Dentistry and Medicine
- Wound Healing and Treatments
- Alcohol Consumption and Health Effects
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Zebrafish Biomedical Research Applications
- Radiomics and Machine Learning in Medical Imaging
- Gout, Hyperuricemia, Uric Acid
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Axon Guidance and Neuronal Signaling
- Salivary Gland Tumors Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Breast Lesions and Carcinomas
Affiliated Zhongshan Hospital of Dalian University
2013-2025
Southern Medical University
2010-2021
Nanjing Drum Tower Hospital
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
University of California, Davis
2017
Central People's Hospital of Zhanjiang
2007-2009
Increasing evidence indicates that stimulating hippocampal neurogenesis could provide novel avenues for the treatment of depression, and recent studies have shown in vitro is enhanced by hypoxia. The aim this study was to investigate potential regulatory capacity an intermittent hypobaric hypoxia (IH) regimen on its possible antidepressant-like effect. Here, we show IH promotes proliferation endogenous neuroprogenitors leading more newborn neurons hippocampus adult rats. Importantly,...
A better understanding of the blood supply femoral head is essential to guide therapeutic strategies for patients with neck fractures. However, because limitations conventional techniques, precise distribution and characteristics intraosseous arteries are not well displayed.To explore interconnections vessel system between different areas possible compensatory mechanism after fracture.The three-dimensional (3-D) structures in 30 uninjured normal human heads were reconstructed using...
The treatment of acetabular defects is one the most difficult challenges revision total hip arthroplasty (RTHA), and tantalum regarded as a promising bone substitute material. This study aims to investigate effectiveness 3D printed augment used in RTHA for defect.A retrospective analysis clinical data seven patients who had undergone was carried out using from January 2017 December 2018. CT were exported Mimics 21.0 software (Materialise, Leuven, Belgium), defect designed, then implanted...
The aim of this report is to present our experience on the use digital subtraction angiography (DSA) in selection vascularized greater trochanter bone grafting for treatment osteonecrosis femoral head (ONFH) early stages. Between January 2005 and June 2007, DSA was used evaluate blood perfusion stages ONFH 32 patients (45 hips). There were 18 males 14 females with an average age 30 years old. Twenty-one hips ARCO stage I, 24 II. arterial supply insufficiency found 22 by DSA, venous stasis 23...
To investigate the collapse mechanism in osteonecrosis of femoral head (ONFH), we studied relationship between (FH) blood circulation changes and area histomorphometry characteristics.A technique involving microvascular perfusion FH vitro to reconstruct vessels at different stages nontraumatic ONFH (40 cases). In addition, also examined characteristics during using hard tissue section technique. supply on pathological involved process.The results showed that all FHs, always margin necrotic...
Abstract We describe a technique for perfusing barium sulphate suspension into the intraosseous artery. Following perfusion of abarium 14 fresh lower limbs Chinese cadavers, micro‐ CT scanning was applied to digitize, quantify and visualize arteries in human femoral heads. Then, heads were removed subjected scanning. The data imported amira mimics programs reconstruct arteries. head artery lengths, areas, volumes, bone volumes quantified. densities ratios calculated analysed with...
Objective Many methods of acetabular reconstruction with total hip arthroplasty (THA) for Crowe type II and III adult developmental dysplasia the (DDH) bone defect have been implemented clinically. However, there was no study comparing results integrated prosthesis (IAP) grafting (BG). This aims to investigate efficacy IAP BG in DDH. Methods The clinical data 45 patients unilateral DDH who underwent THA from January 2020 2023 were retrospectively analyzed. divided into two groups: 25 using...
The present study investigates the feasibility of micro perfusion femoral head specimens from neck fracture patients by inferior retinacular arteries and performing intraosseous artery quantitative analysis head. Twelve who had undergone conventional hip replacement surgery were included in this study. Femoral specimen first dissected exposed then perfused all heads underwent micro-CT scanning. After scanning, a digital 3-D model was reconstructed to quantify for comparison with normal...
With the development of material science, hydrogels with antibacterial and wound healing properties are becoming common. However, injectable simple synthetic methods, low cost, inherent properties, promoting fibroblast growth rare. In this paper, a novel hydrogel dressing based on carboxymethyl chitosan (CMCS) polyethylenimine (PEI) was discovered constructed. Since CMCS is rich in -OH -COOH PEI -NH2, two can interact through strong hydrogen bonds, it theoretically feasible to form gel. By...
The purpose of this report is to present a method revascularization the femoral head for treatment neck fracture in young adult. patient 22-year-old male with Garden type III. We performed an open reduction internal fixation and repaired superior retinacular vessels using microsurgical techniques achieve head. A desensitized-digital subtraction angiography examination showed that blood supply from artery was re-established three months after surgery. X-ray had normal shape without any...
Objective: To evaluated the outcome of prevention and treatment for glucocorticoid-induced osteonecrosis femoral head with anticoagulant vasodilator drugs. Methods: A prospective, randomized, double-blind study was performed. From August 2003 to 2006, 58 patients large amounts hormone therapy in Zhongshan Hospital Affiliated Dalian University were enrolled randomly assigned control group (placebo) or preventive (anticoagulant drugs). And we prospectively analyzed clinical outcomes 24 early...
Abstract Objective To explore the clinical effect of a new type bidirectional pressurized porous tantalum screw (PTS) internal fixation in treating femoral neck fractures (FNFs). Methods In this study, geometric models FNF were first established via reverse engineering method, followed by stimulation strength PTSs FNFs. A randomized control trial study was then conducted 41 patients with from October 2015 to December 2018. These included 12 males and 29 females an average age 59.9. The...
Introduction Nontraumatic osteonecrosis of the femoral head (NONFH) is a common and difficult disease in orthopedics. Magnetic resonance imaging (MRI) assessment NONFH bone marrow edema was combined with digital subtraction angiography (DSA) to evaluate circulatory status different Association Research Circulation Osseous stages. Based on obstruction (venous stasis, arterial ischemia, occlusion), appropriate perioperative management adopted achieve hip joint preservation effectively delay...
Objective: To investigate the feasibility of trans-catheter closure multiple atrial septal defects (ASD) monitored by trans-thoracic echocardiography (TTE) under guidance 3D printing heart model. Methods: Between April and August 2016, a total 21 patients (8 male 13 female) with ASD in Fuwai Hospital Chinese Academy Medical Sciences underwent CT scan 3-dimensional for disease model produced technique. The best occlusion program was determined through simulation test on Percutaneous device...
Clinical angiography and vascular microperfusion confirmed that the femoral head retains blood supply after a collum femur fracture. However, no animal model accurately mimics this clinical situation. This study was performed to establish rat with retained viability of partial vasculature deprivation-induced traumatic caput femoris necrosis by surgery.Thirty rats were randomly divided into three groups (n = 10 per group): normal group, sham-operated group (Control), ischemic osteonecrosis...
To define if exposure to tobacco smoke (TS) could induce reduction of bone mass and impairment architecture, features observed in osteoporosis normotensive rats the influence TS on osteoporotic exhibited spontaneously hypertensive (SH) rats.
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and has been associated with periods intense lung inflammation. The objective this study was to characterize whether similar rat strains, possessing different genetic predispositions, might play a role in exacerbating pathophysiology COPD-like cellular structural changes progressive 12-week exposure tobacco smoke (TS). Normotensive Wistar Kyoto (WKY) spontaneously hypertensive (SH) rats were...
Objective. To investigate the feasibility of using 3D printed personalized guide plates in core decompression procedures for treatment osteonecrosis femoral head (ONFH). Methods. The clinical data 8 patients undergoing from January to December 2019 were analyzed retrospectively. Three-dimensional (3D) images reconstructed CT scan taken preoperatively. From obtained, puncture position, drill hole, and depth evaluated, individualized designed Mimics 21.0 software. During operation, needle went...
The aim of this study was to investigate the relationship between femoroacetabular impingement (FAI) and superior retinacular artery interruption using plain radiographs digital subtraction angiography (DSA).Sixty-one patients included in were divided into 2 groups based on integrity as evaluated DSA images. Group A intact arteries: 33 (24 men, 9 women,); group B interrupted 28 (21 7 women). parameters abnormal radiographic findings thought be associated with FAI, including positive...
Osteonecrosis of the femoral head (ONFH) often affects young, active patients, and head's preservation is primary goal treatment for this disease. Vascularized iliac crest bone grafting one many vascularized procedures used in treating ONHF. In some cases, we selectively performed procedure using musculoperiosteal flap with ascending branch lateral circumflex artery ONFH treatment.Twelve patients (12 hips) nontraumatic necrosis underwent transfer artery. The Harris Hip Score (HHS), visual...