Smart theranostic SPION-NIPAM produced in small sizes show high drug loading capacity and pH/temperature-sensitive release which is also influenced by PNIPAM molecular weight.

Abstract Diffusion magnetic resonance imaging (dMRI) is pivotal for probing the microstructure of rapidly-developing fetal brain. However, motion during scans and its interaction with field inhomogeneities result in artifacts data scattering across spatial angular domains. The effects those are more pronounced high-angular resolution dMRI, where signal-to-noise ratio very low. Those lead to biased estimates compromise consistency reliability dMRI analysis. This work presents HAITCH, first...

Magnetic particle imaging (MPI) has been shown to provide remarkable contrast for applications such as angiography, stem cell tracking, and cancer imaging. Recently, there is growing interest in the functional capabilities of MPI, where 'color MPI' techniques have explored separating different nanoparticles, which could potentially be used distinguish nanoparticles states or environments. Viscosity mapping a promising application increased viscosity levels vivo associated with numerous...

Magnetic particle imaging (MPI) is a novel modality with important potential applications, such as angiography, stem cell tracking, and cancer imaging. Recently, there have been efforts to increase the functionality of MPI via multi-color methods that can distinguish responses different nanoparticles, or nanoparticles in environmental conditions. The proposed techniques typically rely on extensive calibrations capture differences harmonic nanoparticles. In this paper, we propose method...

Magnetic particle imaging (MPI) uses superparamagnetic iron oxide (SPIO) nanoparticles as biomedical tracers. The potential applications of MPI have recently been broadened by the introduction “color” techniques that can distinguish different and/or environments, e.g., exploiting relaxation behavior SPIOs. One important color is viscosity mapping. In this work, we show relaxation-based experiments biologically relevant range up to 5 mPa s. To find optimal drive field parameters for...

Magnetic particle imaging (MPI) is emerging as a highly promising modality. nanoparticles (MNPs) are used tracers in MPI, and their relaxation behavior provides the foundation for its functional capability. Since MNPs also utilized magnetic fluid hyperthermia (MFH) MPI enables localized MFH, temperature mapping arises an important application area of MPI. To achieve accurate estimations, however, one must take into account confounding effects viscosity on signal. In this work, we analyze MNP...

Anisotropic macromolecules exposed to non-equilibrium (active) noise are very common in biological systems, and an accurate understanding of their anisotropic dynamics is therefore crucial.

Abstract The demand for highly efficient cancer diagnostic tools increases alongside the high incidence nowadays. Moreover, there is an imperative need novel treatment therapies that lack side effects of conventional options. Developments in this aspect employ magnetic nanoparticles (MNPs) biomedical applications due to their stability, biocompatibility, and properties. Certain organisms, including many bacteria, can synthesize nanocrystals, which help spatial orientation survival by sensing...

Motivation: To correct breathing-induced field fluctuations and ensuing artifacts on T2*-weighted MRI of the cervical cord to improve T2* mapping. Goal(s): characterize B0 changes caused by respiration within retrospectively compensate for those spatiotemporal using a FID navigator-based correction technique. Approach: coefficients up second order were measured navigators multi-channel low-resolution reference image. Retrospective was performed during an iterative image reconstruction....

Magnetic Particle Imaging (MPI) has gained a variety of potential applications since its first introduction in 2005 [1]. It offers safe tracers with angiography, stem cell tracking, and cancer imaging [2]. The response superparamagnetic iron oxide (SPIO) nanoparticles strongly affects the quality MPI images, which is unique not-before-seen feature for medical system [3]. In theory, as diameter nanoparticle increases, resolution also increases [1-4]. reality, however, larger start to lag...

In magnetic particle imaging (MPI), simultaneous excitation and signal acquisition leads to direct feedthrough problems.  While this direct-feedthrough can be mitigated up some extent with passive compensation, may not sufficient given the time-variant nature of system. Active compensation methods are proposed overcome challenge. resonance (MRI), we have recently a promising active technique that uses vector modulator-like structure modify copy transmitted use it for subtracting in analog...

Magnetic Particle Imaging (MPI) has been rapidly developing since its first publication at 2005 with significant progress in application areas such as angiograpgy, stem cell tracking, and cancer imaging. MPI promise to be a safe imaging modality due using non-ionizing radiation non-toxic iron oxide nanoparticles tracer. Although there is no human-sized scanner built so far, preclinial studies have shown that submilimeter resolution. In this work, we are presenting the design construction...

Multi-shot EPI can be a promising technique to improve the resolution limits of single shot EPI. However, its application has been so far limited in abdominal MRI, as phase errors between shots due unavoidable breathing motion creates artifacts images. Here, we tested Variable-Flip-Angle Fast Low-angle Excitation Echo planar Technique (VFA-FLEET) pulse sequence and showed that it used create high-resolution motion-robust images with high geometric fidelity without breath holding.

3D EPI is a clinically promising alternative for susceptibility weighted imaging due to multi-shot acceleration. However, achieving submillimeter resolution with challenging as shot-to-shot B0 variations result in artifactual images that limit detection of small veins which can be decisive the central vein sign multiple sclerosis. FID navigators have been shown estimate phase drifts sequences. We demonstrate FID-navigated acquisitions enable correction phase-induced distortions and achieve...

Motivation: Current methods for T2 mapping are time-consuming and susceptible to motion artifacts, hindering their clinical utility. Goal(s): Our goal is develop a rapid motion-robust technique. By significantly reducing scan times eliminating we aim enhance the feasibility of quantitative across diverse patient populations. Approach: Standard spin-echo EPI sequence was modified by incorporating additional readouts with alternating phase-encoding directions. Geometric distortions due...

In magnetic particle imaging (MPI), selection field (SF) gradients are utilized to form a field-free point (FFP) in space, such that only the nanoparticles (MNPs) vicinity of FFP respond applied drive (DF) and contribute received signal. While relaxation behavior MNPs adversely affects image quality by reducing signal intensity causing blurring, it also provides MPI with functional capabilities, as viscosity temperature mapping. This work investigates effects SF on using an in-house...

In magnetic particle imaging (MPI), simultaneous excitation and signal acquisition leads to direct feedthrough interference. While this interference can be mitigated up some extent with passive compensation, its time-varying nature necessitates active compensation methods achieve the sensitivity levels needed for applications such as stem cell tracking. We have recently proposed an technique MRI, which uses a vector modulator lookup-table-based algorithm reducing in analog domain. Here, we...

Motivation: Previous studies have demonstrated field correction with 3D-EPI for fMRI and SWI, but ideal would account both inhomogeneities motion. Goal(s): We aimed to investigate the limits of simultaneous motion 3D-EPI. Approach: Our approach was acquire in vivo data controlled head Volunteers were directed rotate their heads 4-8 degrees move left/right during scanning. performed using FID navigators after rigid registration. Results: Analysis across varying rotation showed ability...

Motivation: Accurately assessing fetal lung maturity and development with quantitative diffusion parameters could guide critical care for at-risk fetuses, but has been severely limited by artifacts. Goal(s): Develop an MRI technique to enable reliable imaging of lungs. Approach: Investigated a multi-echo spin echo sequence provide motion/distortion correction. Results: The improved analysis, in particular, resulting more consistent ADC fitting. method also increased the geometric fidelity...

This paper investigates the properties of superparamagnetic iron oxide (SPIO) nanoparticles for simultaneous MPI imaging and hyperthermia therapy. For that purpose, FeraSpin SPIO varying sizes (FeraSpin XS to XL, with hydrodynamic diameters ranging between 10 nm 70 nm) different concentrations (~ μM mM) are utilized investigate their heating efficiencies (i.e., specific absorption rate - SAR) as a function applied magnetic field. Once setup is fully functional, our results will provide...

In magnetic particle imaging (MPI), the relaxation behavior of nanoparticles has been exploited to expand quantitative mapping capabilities MPI applications such as viscosity and temperature mapping. We have previously proposed a technique called TAURUS estimate time constant directly from signal, demonstrated its via experiments. this work, we extend demonstrate capability 1D experiments at two different temperatures.   Int. J. Mag. Part. Imag. 6(2), Suppl. 1, 2020, Article ID: 2009066,...