Abstract The formation of long‐term memory requires protein synthesis, particularly during initial consolidation. This process also seems to be dependant upon degradation, degradation by the ubiquitin‐proteasome system. aim this study was investigate temporal requirement synthesis and consolidation allocentric spatial learning. As returns a labile state reactivation, we focus on role reconsolidation Male CD1 mice were submitted massed training in version Morris water maze. At various time...

Progress in understanding the roles of kainate receptors (KARs) synaptic integration, networks, and higher brain function has been hampered by lack selective pharmacological tools. We have found that UBP310 related willardiine derivatives, previously characterized as GluK1 GluK3 KAR antagonists, block postsynaptic KARs at hippocampal mossy fiber (MF) CA3 synapses while sparing AMPA NMDA receptors. further show is an antagonist recombinant GluK2/GluK5 receptors, major population brain....

Translational control of long-term synaptic plasticity via Mechanistic Target Of Rapamycin Complex 1 (mTORC1) is crucial for hippocampal learning and memory. The role mTORC1 well characterized in excitatory principal cells but remains largely unaddressed inhibitory interneurons. Here, we used cell-type-specific conditional knock-out strategies to alter function selectively somatostatin (SOM) interneurons (SOM-INs). We found that, male mice, upregulation downregulation SOM-IN activity...

Dentate granule cells, at the gate of hippocampus, use coincidence detection synaptic inputs to code afferent information under a sparse firing regime. In both human patients and animal models temporal lobe epilepsy, mossy fibers sprout form an aberrant glutamatergic network between dentate cells. These new synapses operate via long-lasting kainate receptor-mediated events, which are not present in naive condition. Here, we report that chronic epileptic rat, receptors interplay with...

Abstract Cortical GABAergic interneurons represent a highly diverse neuronal type that regulates neural network activity. In particular, in the hippocampal CA1 oriens/alveus (O/A-INs) area provide feedback dendritic inhibition to local pyramidal cells and express somatostatin (SOM). Under relevant afferent stimulation patterns, they undergo long-term potentiation (LTP) of their excitatory synaptic inputs through multiple induction expression mechanisms. However, cell-type specificity these...

Mutations in TSC1 or TSC2 genes cause tuberous sclerosis complex (TSC), a disorder associated with epilepsy, autism, and intellectual disability. are repressors of the mechanistic target rapamycin 1 (mTORC1), key regulator protein synthesis. Dysregulation mTORC1 TSC mouse models leads to impairments excitation-inhibition balance, synaptic plasticity, hippocampus-dependent learning memory deficits. However, inhibition arises from multiple types inhibitory interneurons how changes specific...

Abstract Our understanding of the memory reconsolidation process is at an earlier stage than that consolidation. For example, it unclear if, as for consolidation, a trace necessitates protein synthesis. In fact, conflicting results appear in literature and this discrepancy may be due to differences experimental reactivation procedure. Here, we addressed question whether synthesis CA3 hippocampal region crucial consolidation allocentric knowledge after different conditions Morris water maze....

Abstract Hippocampal CA1 parvalbumin-expressing interneurons (PV INs) play a central role in controlling principal cell activity and orchestrating network oscillations. PV INs receive excitatory inputs from CA3 Schaffer collaterals local pyramidal cells, they provide perisomatic inhibition. collateral synapses onto express Hebbian anti-Hebbian types of long-term potentiation (LTP), as well elicit LTP intrinsic excitability (LTP IE ). requires the activation type 5 metabotropic glutamate...

Objective Patients with temporal lobe epilepsy often display cognitive comorbidity recurrent seizures. However, the cellular mechanisms underlying impairment of neuronal information processing remain poorly understood in epilepsy. Within hippocampal formation networks undergo major reorganization, including sprouting mossy fibers dentate gyrus; they establish aberrant synapses between granule cells and operate via postsynaptic kainate receptors. In this report, we tested hypothesis that...

Reconsolidation is necessary for the restabilization of reactivated memory traces. However, experimental parameters have been suggested as boundary conditions this process. Here we investigated role a spatial trace's age, strength, and update on reconsolidation process in mice. We first found that protein synthesis to occur hippocampal CA3 region after reactivation partially acquired old memories but not strongly recent memories. also demonstrated previously stable required, again, CA3....

Abstract Translational control of long-term synaptic plasticity via Mechanistic Target Of Rapamycin Complex 1 (mTORC1) is crucial for hippocampal learning and memory. The role mTORC1 well-characterized in excitatory principal cells but remains largely unaddressed inhibitory interneurons. Here we used cell type-specific conditional knockout strategies to alter function selectively somatostatin (SOM) interneurons (SOM-INs). We found that up- down-regulation SOM-IN activity bi-directionally...