A5044109489- Supramolecular Chemistry and Complexes
- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Extraction and Separation Processes
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Electrochemical Analysis and Applications
- Nanoplatforms for cancer theranostics
- Trace Elements in Health
Université Libre de Bruxelles
2020-2025
Here we present the anion binding and transport properties of a series calix[6]arenes decorated on their small rim with either halogen bond or hydrogen donating groups. We show that iodotriazole groups enable highly selective chloride nitrate anions, without protons hydroxide, at rates similar to those observed thiourea squaramide
Lipid bilayers are impermeable to ions, including copper cations. Copper is an essential trace element for life, present in the active site of various enzymes, whereas free detrimental inside cells. homeostasis thus finely controlled, involving Cu(I) transporting membrane proteins Ctr1 and ATP7A/B. Disruption has been reported as a potential anti-cancer strategy. With this objective, we have developed series lipophilic compounds with two coordinating (benz)imidazole groups that able function...
In this communication we present a ligand for copper(<sc>i</sc>) that can selectively extract cation into chloroform and transport across lipid bilayers, as demonstrated in newly developed fluorescence assay.
Abstract Introduction: Cuproptosis is a novel programmed cell death pathway triggered by increased intracellular Copper (Cu) levels. This process offers promising avenues for cancer therapy and underscores the pivotal role of Cu-targeting molecules, such as chelators ionophores. Despite progress made, there still critical need molecules capable disrupting copper homeostasis within cells. Methods: We developed patented class Cu(I) ionophores characterized calix[4]arene structures. The...
Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu + transporters. A series of calix[4]arenes with two imidazole groups has developed their bidentate linear coordination motif allows selective extraction into chloroform. Transmembrane transport liposomes was investigated a newly assay opens way to further development ionophores biomedical applications.
Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu + transporters. A series of calix[4]arenes with two imidazole groups has developed their bidentate linear coordination motif allows selective extraction into chloroform. Transmembrane transport liposomes was investigated a newly assay opens way to further development ionophores biomedical applications.
Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu<sup>+</sup> transporters. A series of calix[4]arenes with two imidazole groups has developed their bidentate linear coordination motif allows selective extraction into chloroform. Transmembrane transport liposomes was investigated a newly assay opens way to further development ionophores biomedical applications.
Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu + transporters. A series of calix[4]arenes with two imidazole groups has developed their bidentate linear coordination motif allows selective extraction into chloroform. Transmembrane transport liposomes was investigated a newly assay opens way to further development ionophores biomedical applications.