A5101966960- Ovarian function and disorders
- Nanoparticle-Based Drug Delivery
- Reproductive Biology and Fertility
- Microbial Natural Products and Biosynthesis
- Advanced Drug Delivery Systems
- Reproductive System and Pregnancy
- Chemical Synthesis and Analysis
- Microbial metabolism and enzyme function
- Metal-Catalyzed Oxygenation Mechanisms
- Curcumin's Biomedical Applications
- Metalloenzymes and iron-sulfur proteins
- Assisted Reproductive Technology and Twin Pregnancy
- Biochemical and Molecular Research
- Endometriosis Research and Treatment
- Rheumatoid Arthritis Research and Therapies
- Prenatal Screening and Diagnostics
- Genetics, Aging, and Longevity in Model Organisms
- Ocular Surface and Contact Lens
- Pituitary Gland Disorders and Treatments
- Nutrition, Genetics, and Disease
- Metabolism and Genetic Disorders
- Hemoglobin structure and function
- Obsessive-Compulsive Spectrum Disorders
- Peptidase Inhibition and Analysis
- Biochemical and Structural Characterization
Shandong University
2012-2024
Sun Yat-sen University
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
State Key Laboratory of Microbial Technology
2022-2023
East China Normal University
2020
Shaanxi University of Chinese Medicine
2020
Zhaotong University
2013
Objective To study the role of selected serum inflammatory cytokines and berberine in insulin signaling pathway among women with polycystic ovary syndrome (PCOS). Methods Selected were analyzed particle cells, which interfered by berberine, from 78 infertile who to be treated In Vitro Fertilization (IVF) /Intracytoplasmic Sperm Injection-Embryo Transfer (icsi-et). Among them, 49 patients had PCOS infertility, 29 non-PCOS whose infertility resulted fallopian tube male factors. The elisa...
Although curcumin (CUR) can inhibit proliferation and induce apoptosis of tumors, the poor water solubility restricted its clinical application. The aim this study was to improve aqueous CUR make more favorable changes bioactivity by preparing curcumin-loaded phospholipid-sodium deoxycholate-mixed micelles (CUR-PC-SDC-MMs). CUR-PC-SDC-MMs were prepared thin-film dispersion method. Based on results single factor exploration, preparation technology optimized using central composite...
Luteinization is the event of corpus luteum formation, a way follicle cells transformation and process steroidogenesis alteration. As core clock gene, Bmal1 was involved in regulation ovulation luteal function afterwards. Till now, underlying roles luteinization played by remain unknown. To explore unique role its pathway, we investigated hormone synthesis profile knockout female mice. We found that notably impaired, phosphorylation PI3K/NfκB pathway significantly activated. Then, results...
Controlled ovarian stimulation (COS) is one of the most vital parts in vitro fertilization-embryo transfer (IVF-ET). At present, no matter what kinds COS protocols are used, clinicians have to face challenge selection gonadotropin starting dose. Although several nomograms been developed calculate appropriate dose releasing hormone (GnRH) agonist protocol, nomogram was suitable for GnRH antagonist protocol. This study aimed develop a predictive individualized Single-center prospective cohort...
In vitro characterization experiments revealed the formations of 3-(trans-2'-aminocyclopropyl)alanine ((3-Acp)Ala) and 3-(trans-2'-nitrocyclopropyl)alanine ((3-Ncp)Ala) are originated via two homologous proteins, BelK HrmI, which regioselectively catalyze Nε-oxygenation l-lysine. The enzymes belong to emerging heme-oxygenase-like diiron oxidase oxygenase (HDO) superfamily catalytic center is validated by homology modeling site-directed mutations. Based on in characterization, biosynthetic...
Antral follicles consist of an oocyte cumulus complex surrounding by somatic cells, including mural granulosa cells as the inner layer and theca outsider layer. The communications between oocytes have been extensively explored in vitro studies, however, role oocyte-derived factor GDF9 on vivo antral follicle development remains elusive due to lack appropriate animal model. Clinically, phenotype variants needs be determined.
Non-ribosomal peptide synthetases (NRPSs) and their tailored enzymes have diverse biological functions. In this study, we investigated the biosynthesis function of chitinimides, which belong to non-ribosomal (NRP) subfamily featuring a pyrrolidine-containing part (X part) connected polypeptide chain via an ester bond. A conserved gene cassette, chmHIJK, is responsible for oxyacylation pyrrolidine moiety in X part. The thioesterase (TE) domain ChmC (ChmC-TE) catalyzes transesterification...
Abstract Aim To investigate whether treated hyperprolactinemia has an impact on pregnancy outcomes in vitro fertilization/intracytoplasmic sperm injection‐embryo transfer (IVF/ICSI‐ET). Methods A retrospective cohort study was conducted 535 women who underwent IVF/ICSI‐ET between January 2012 and December 2016, of which 123 had (case group), 369 were matched controls. Besides, 43 remained hyperprolactinemic after treatment consisted abnormal group. Cumulative live birth rate (CLBR) one...
We report that GvgD catalyzes a reversible amidinylation of l -canaline and GvgH installs the aminooxy group via γ-elimination addition.
Lasso peptides are ribosomally synthesized that undergo post-translational modifications including leader peptide removal by B (or the segregated B1 and B2) proteins core macrolactamization C to form a unique lariat topology. A conserved threonine residue at penultimate position of is hitherto found in lasso precursors shown be critical recognition element for effective enzymatic processing. We identified biosynthetic gene cluster (bsf) from Bradymonas sediminis FA350, Gram-negative...
To explore the relationship between parental hypertension history and in children adolescents based on relevant data of 6 049 aged to 17 years old Jinan city from September 2012 2014. The results showed that parents was positively correlated with systolic blood pressure adolescents, value coefficient β (95%CI) about 0.91 (0.23-1.59). Compared whose had no hypertension, those one parent both were more likely develop OR values 1.28 (1.01-1.61) 2.24 (1.09-4.61), respectively. Therefore, it is...
In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine ((3-Acp)Ala) and 3-(trans-2’-nitrocyclopropyl)alanine ((3-Ncp)Ala) are originated via two homologous proteins BelK HrmI, which regioselectively catalyze Nε-nitration L-lysine. The enzymes belong to emerging heme-oxygenase-like diiron oxidase oxygenase (HDO) superfamily catalytic center is validated by homology modeling site-directed mutations. Based on in characterization, biosynthetic...
In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine ((3-Acp)Ala) and 3-(trans-2’-nitrocyclopropyl)alanine ((3-Ncp)Ala) are originated via two homologous proteins BelK HrmI, which regioselectively catalyze Nε-nitration L-lysine. The enzymes belong to emerging heme-oxygenase-like diiron oxidase oxygenase (HDO) superfamily catalytic center is validated by homology modeling site-directed mutations. Based on in characterization, biosynthetic...