A5018384480- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Vascular Malformations Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Photoreceptor and optogenetics research
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
University of York
2019-2024
York Teaching Hospital NHS Foundation Trust
2020-2024
Hull York Medical School
2023-2024
Visual Acuity (VA) and structural biomarker assessment before at 24-months after early detection routine treatment of second eye involvement with neovascular age-related macular degeneration (nAMD) additional comparison the first affected. Prospective, 22-centre observational study participants unilateral nAMD in Early Detection Neovascular AMD (EDNA) study, co-enrolled into Observing fibrosis, atrophy subretinal highly reflective material, intervention anti-VEGF (FASBAT) for an 2-year...
To assess the effectiveness, burden and safety of two categories treatment for central retinal vein occlusion (CRVO): intravitreal injections anti-vascular endothelial growth factor (anti-VEGF) dexamethasone (Ozurdex).A retrospective analysis Medisoft electronic medical record (EMR) data from 27 National Health Service sites in UK identified 4626 treatment-naive patients with a single mode macular oedema secondary to CRVO. Statistics describing overall CRVO patient cohort individual...
Purpose: Previous research has shown atrophy of visual cortex can occur in retinotopic representations retinal lesions resulting from eye disease. However, the time course cannot be established these cross-sectional studies, which included patients with longstanding disease varying severity. Our aim, therefore, was to measure cortical structure over participants after onset unilateral loss AMD. Methods: Inclusion criteria were acute neovascular AMD bilateral dry based on clinical...
To date there are yet no available approved therapies for Geographic Atrophy (GA) secondary to age-related macular degeneration (AMD).Single site, non-randomized safety and efficacy study presenting the preliminary results in a cohort of five late stage AMD patients successfully implanted with Argus II Retinal Prosthesis System (Second Sight Medical Products Inc., Sylmar, CA, USA). Extensive fundus imaging including retinal photographs from which GA area was measured. A combination custom...
Purpose: The aim of this study was to assess both retinal and cortical structure in a cohort patients with long-term acquired central disease order identify potential biomarkers explore the relationship between anterior posterior visual pathways. Methods: Fourteen participants diagnosed underwent structural assessments retina using spectral-domain optical coherence tomography, including macular ganglion cell layer (GCL) peripapillary nerve fiber (pRNFL) thickness. Structural magnetic...
Abstract Macular degeneration (MD) embodies a collection of disorders causing progressive loss central vision. Cross-sectional MRI studies have revealed structural changes in the grey and white matter posterior visual pathway MD but there remains need to understand how such progress over time. To that end we assessed pathway, characterising cortex optic radiations ~ 2-year period patients controls. We performed cross-sectional longitudinal analysis former. Reduced cortical thickness...
Abstract Background/objectives In healthcare research investigating complex interventions, gaps in understanding of processes can be filled by using qualitative methods alongside a quantitative approach. The aim this mixed-methods pilot trial was to provide feasibility evidence comparing two treatment regimens for neovascular age-related macular degeneration (nAMD) inform future large-scale randomised controlled (RCT). Subjects/methods Forty-four treatment-naïve nAMD patients were followed...
Abstract Purpose Data are limited pertaining to the long‐term benefits of aflibercept treatment for neovascular age‐related macular degeneration (nAMD). The aim this study was provide outcomes, safety, durability and quality‐of‐life data with using a modified treat, extend fixed regime over 4 years. Methods Prospective, multicentre, single cohort observational treatment‐naïve nAMD participants treated as 2‐year extension MATE‐trial that compared early late Treat‐and‐Extend 2 Refracted ETDRS...