A5033309669- Medicinal Plant Pharmacodynamics Research
- Angiogenesis and VEGF in Cancer
- HER2/EGFR in Cancer Research
- Flavonoids in Medical Research
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Cancer therapeutics and mechanisms
- Diabetes Treatment and Management
- Multiple Myeloma Research and Treatments
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Analytical Chemistry and Sensors
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- Metabolomics and Mass Spectrometry Studies
Institute for Molecular Medicine Finland
2020-2024
University of Helsinki
2020-2024
Ministry of Health and Family Welfare
2019-2020
Amity University
2019
The tricarboxylic acid (TCA) cycle is a central part of carbon and energy metabolism, also connecting to glycolysis, amino acid, lipid metabolism. quantitation the TCA intermediate within one method lucrative due interest in metabolism profiling cells tissues. In addition, intermediates serum have been discovered correspond as biomarkers various underlying pathological conditions. this work, an Liquid Chromatography-Mass Spectrometry/Mass Spectrometry-based quantification developed...
CD33 (Siglec-3) is a cell surface receptor expressed in approximately 90% of acute myeloid leukemia (AML) blasts, making it an attractive target for therapy AML. Although previous CD33-targeting antibody-drug conjugates (ADC) like gemtuzumab ozogamicin (GO, Mylotarg) have shown efficacy AML treatment, they suffered from toxicity and narrow therapeutic window. This study aimed to develop novelADCwith improved tolerability wider GLK-33 consists the anti-CD33 antibody lintuzumab eight mavg-MMAU...
Background: A simple and sensitive Ultra Performance Liquid Chromatography-Mass Spectrometry method was developed validated to measure the concentrations of Alogliptin (ALO), Linagliptin (LIN), Saxagliptin (SAX), Sitagliptin (SIT) using Pioglitazone (PIO) as an internal standard. Methods: Chromatographic separation six gliptins achieved on a C-18 column (100×2.1 mm, 2.7 μm) mobile phase consisting formic acid in water, 0.1%v/v: acetonitrile gradient elution. Electrospray ionization (ESI)...
<p>Ex vivo cytotoxicity assays with leukemia blast samples.</p>
<p>Supplementary Methods and Results</p>
<p>GLK-33 binding and internalization to CD33+ cells.</p>
<p>Characterization of overconjugated GLK-33 batch in rat tolerability and toxicokinetic study.</p>
<p>Supplementary Methods and Results</p>
<p>Characterization of LN-mcvc-MMAE DAR4 (lintuzumab vedotin).</p>
<div>Abstract<p>CD33 (Siglec-3) is a cell surface receptor expressed in approximately 90% of acute myeloid leukemia (AML) blasts, making it an attractive target for therapy AML. Although previous CD33-targeting antibody–drug conjugates (ADC) like gemtuzumab ozogamicin (GO, Mylotarg) have shown efficacy AML treatment, they suffered from toxicity and narrow therapeutic window. This study aimed to develop novelADCwith improved tolerability wider GLK-33 consists the anti-CD33...
<p>GLK-33 binding and internalization to CD33+ cells.</p>
<p>Ex vivo cytotoxicity assays with leukemia blast samples.</p>
<p>Comparison of MTD and TI GLK-33 with comparator ADCs.</p>
<p>Characterization of overconjugated GLK-33 batch in rat tolerability and toxicokinetic study.</p>
<p>Characterization of LN-mcvc-MMAE DAR4 (lintuzumab vedotin).</p>
<p>Comparison of MTD and TI GLK-33 with comparator ADCs.</p>
<div>Abstract<p>CD33 (Siglec-3) is a cell surface receptor expressed in approximately 90% of acute myeloid leukemia (AML) blasts, making it an attractive target for therapy AML. Although previous CD33-targeting antibody–drug conjugates (ADC) like gemtuzumab ozogamicin (GO, Mylotarg) have shown efficacy AML treatment, they suffered from toxicity and narrow therapeutic window. This study aimed to develop novelADCwith improved tolerability wider GLK-33 consists the anti-CD33...
Background: A simple and sensitive ultra-performance liquid chromatography-mass spectrometry method was developed validated to measure the concentrations of gemigliptin (GEM) teneligliptin (TEN) using pioglitazone (PIO) as an internal standard. Methods: Chromatographic separation two gliptins achieved on a C-18 (100 mm X 2.1 mm, 2.7 μm) column mobile phase consisting formic acid in water (0.1 % v/ v): acetonitrile gradient elution. Electrospray ionization (ESI) source operated positive mode...