Stefano Gualdi

ORCID: 0000-0002-2605-9292
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About
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Research Areas
  • Cystic Fibrosis Research Advances
  • Vibrio bacteria research studies
  • Bacterial biofilms and quorum sensing
  • Heavy metals in environment
  • Nanoparticles: synthesis and applications
  • Legume Nitrogen Fixing Symbiosis
  • Arsenic contamination and mitigation
  • Ocean Acidification Effects and Responses
  • Marine Biology and Environmental Chemistry
  • Trace Elements in Health
  • Chromium effects and bioremediation
  • Aquaculture Nutrition and Growth
  • Marine Sponges and Natural Products
  • Marine Bivalve and Aquaculture Studies
  • Parasite Biology and Host Interactions

University of Zurich
2017-2025

It is now recognized that host microbiome, the community of microorganisms colonize animal body (e.g. microbiota) and their genomes, play an important role in health status all organisms, from nutrient processing to protection disease. In particular, complex, bilateral interactions between innate immune system microbiota are crucial maintaining whole homeostasis. The development nanotechnology raising concern on potential impact nanoparticles-NPs human environmental health. Titanium...

10.1016/j.scitotenv.2019.03.133 article EN cc-by-nc-nd The Science of The Total Environment 2019-03-14

Summary Infectious agents such as the bacteria Vibrio aestuarianus or Ostreid herpesvirus 1 have been repeatedly associated with dramatic disease outbreaks of Crassostrea gigas beds in Europe. Beside roles played by these pathogens, microbial infections C . may derive from contribution a larger number microorganisms than previously thought, according to an emerging view supporting polymicrobial nature bivalve diseases. In this study, communities large samples collected during recurrent...

10.1111/1462-2920.14750 article EN cc-by Environmental Microbiology 2019-07-20

ABSTRACT Burkholderia cenocepacia is an opportunistic pathogen that has been associated with nosocomial outbreaks in hospitals and can cause severe respiratory infections among immunocompromised patients individuals suffering from cystic fibrosis. The transmissibility intrinsic antibiotic resistance of B. pose a significant challenge healthcare settings. In this study, the aim to identify novel drug targets fight infections, we employed genome-wide transposon sequencing (Tn-seq) approach...

10.1128/msystems.01354-24 article EN cc-by mSystems 2025-03-19

ABSTRACT The study of the minimum set genes required to sustain life is a fundamental question in biological research. Recent studies on bacterial essential suggested that between 350 and 700 are support autonomous cell growth. Essential interest as potential new antimicrobial drug targets; hence, our aim was identify genome cystic fibrosis (CF) isolate Burkholderia cenocepacia H111. Using transposon sequencing (Tn-Seq) approach, we identified for growth rich medium under aerobic microoxic...

10.1128/jb.00260-17 article EN Journal of Bacteriology 2017-08-29

Summary Copper is an essential element but in excess highly toxic and therefore cytoplasmic levels must be tightly controlled. Member of the genus Burkholderia are resistant to various heavy metals often isolated from acidic soils where copper bioavailability high. In this study, we employed transposon sequencing (Tn‐Seq) identify resistance genes cenocepacia H111. We identified a efflux system that shares similarities with plasmid‐based detoxification systems found Escherichia coli...

10.1111/1758-2229.12828 article EN Environmental Microbiology Reports 2020-02-24

Summary Members of the genus Burkholderia show remarkable abilities to adapt a wide range environmental conditions and is frequently isolated from soils contaminated with heavy metals. In this study, we used transposon sequencing approach identify 138 164 genes that provide benefit for growth opportunistic pathogen cenocepacia H111 in presence silver gold ions respectively. The data suggest arginine metabolism citrate biosynthesis are important tolerance, while components an ABC transporter...

10.1111/1462-2920.15471 article EN Environmental Microbiology 2021-03-18
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