Brian Pietrosimone

ORCID: 0000-0002-2632-413X
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About
Contact & Profiles
Research Areas
  • Knee injuries and reconstruction techniques
  • Total Knee Arthroplasty Outcomes
  • Sports injuries and prevention
  • Osteoarthritis Treatment and Mechanisms
  • Muscle activation and electromyography studies
  • Lower Extremity Biomechanics and Pathologies
  • Shoulder Injury and Treatment
  • Foot and Ankle Surgery
  • Tendon Structure and Treatment
  • Sports Performance and Training
  • Cardiovascular Effects of Exercise
  • Effects of Vibration on Health
  • Transcranial Magnetic Stimulation Studies
  • Ultrasound Imaging and Elastography
  • Orthopedic Surgery and Rehabilitation
  • Photoacoustic and Ultrasonic Imaging
  • Ultrasonics and Acoustic Wave Propagation
  • Winter Sports Injuries and Performance
  • Motor Control and Adaptation
  • Injury Epidemiology and Prevention
  • Sport Psychology and Performance
  • Traumatic Brain Injury Research
  • Musculoskeletal pain and rehabilitation
  • Ergonomics and Musculoskeletal Disorders
  • Bone fractures and treatments

University of North Carolina at Chapel Hill
2016-2025

Duke University
2019-2024

University of North Carolina Health Care
2017-2024

High Point University
2023

Duke University Health System
2020-2022

Florida State University
2021-2022

University of Colorado Anschutz Medical Campus
2022

Applied Physical Sciences (United States)
2022

Duke University Hospital
2018-2021

Duke Medical Center
2020-2021

Quadriceps strength is a useful clinical predictor of self-reported function after anterior cruciate ligament reconstruction (ACLR). However, it remains unknown if quadriceps normalized to body mass (QBM) or limb symmetry index (QLSI) the best in individuals with ACLR. We sought determine whether QBM and QLSI are able predict ACLR who self-report high (≥90% on international knee documentation committee (IKDC) index).Ninety-six history primary unilateral were recruited for multisite...

10.1249/mss.0000000000000946 article EN Medicine & Science in Sports & Exercise 2016-04-19

The purpose of our study was to determine the association between biomechanical outcomes walking gait (peak vertical ground reaction force [vGRF], vGRF loading rate [vGRF-LR], and knee adduction moment [KAM]) 6 months following anterior cruciate ligament reconstruction (ACLR) biochemical markers serum type-II collagen turnover (collagen cleavage product C-propeptide [C2C:CPII]), plasma degenerative enzymes (matrix metalloproteinase-3 [MMP-3]), a pro-inflammatory cytokine (interleukin-6...

10.1002/jor.23534 article EN Journal of Orthopaedic Research® 2017-02-02

Background: Individuals who have sustained an anterior cruciate ligament (ACL) injury and undergo ACL reconstruction (ACLR) are at higher risk of developing knee osteoarthritis. It is hypothesized that altered loading may influence the underlying joint metabolism hasten development posttraumatic Purpose: To explore associations between serum biomarkers cartilage peak vertical ground-reaction force (vGRF) vGRF rate in injured uninjured limbs individuals with ACLR. Study Design: Descriptive...

10.1177/0363546515618380 article EN The American Journal of Sports Medicine 2015-12-18

Chronic quadriceps dysfunction has been implicated as a contributor to knee osteoarthritis (OA) development after anterior cruciate ligament reconstruction (ACLR). This potentially leads impulsive/high-rate loading during gait, thus accelerating cartilage degradation. The purpose of this study was examine relationships between several indices function and gait biomechanics linked OA in individuals with ACLR.Gait were assessed 39 ACLR. Indices included isometric peak torque rate (RTD),...

10.1249/mss.0000000000000963 article EN Medicine & Science in Sports & Exercise 2016-04-29

ABSTRACT Purpose Aberrant walking biomechanics after anterior cruciate ligament reconstruction (ACLR) are hypothesized to be associated with deleterious changes in knee cartilage. T1ρ magnetic resonance imaging (MRI) is sensitive decreased proteoglycan density of Our purpose was determine associations between MRI interlimb ratios (ILR) and 6 months ACLR. Methods Walking (peak vertical ground reaction force (vGRF), vGRF loading rate, extension moment, abduction moment) were extracted from the...

10.1249/mss.0000000000001834 article EN Medicine & Science in Sports & Exercise 2018-11-17

Concussion is commonly associated with immediate and persistent alterations in motor function affecting postural control gait. Patients lower extremity joint injury have demonstrated functional the cerebral cortex, suggesting that musculoskeletal may be linked to brain function. Therefore, we examined associations between concussion frequency sustained during professional careers of National Football League (NFL) players a cross-sectional study.An inclusive health history survey was mailed...

10.1249/mss.0000000000000684 article EN Medicine & Science in Sports & Exercise 2015-04-14

Aberrant biomechanics may affect force attenuation at the knee during dynamic activities, potentially increasing risk of sustaining a injury or hastening development osteoarthritis after anterior cruciate ligament reconstruction (ACLR). Impaired quadriceps neuromuscular function has been hypothesized to influence aberrant biomechanics. To determine association between (strength, voluntary activation, and spinal-reflex corticomotor excitability) sagittal-plane jump landings in individuals...

10.4085/1062-6050-306-16 article EN Journal of Athletic Training 2018-01-19

The association between lower-extremity loading and clinically relevant knee symptoms at different time points after anterior cruciate ligament reconstruction (ACLR) is unclear. Vertical ground reaction force (vGRF) from walking was compared individuals with without in three cohorts: <12 months post-ACLR, 12-24 >24 post-ACLR.One hundred twenty-eight unilateral ACLR were classified as symptomatic or asymptomatic, based on previously defined cutoff values for the Knee Osteoarthritis Injury...

10.1249/mss.0000000000001776 article EN Medicine & Science in Sports & Exercise 2018-08-30

ABSTRACT Purpose To compare gait biomechanics throughout stance phase 6 and 12 months after unilateral anterior cruciate ligament reconstruction (ACLR) between ACLR contralateral limbs compared with controls. Methods Vertical ground reaction force (vGRF), knee flexion angle (KFA), internal extension moment (KEM) were collected bilaterally post-ACLR in 30 individuals (50% female, 22 ± 3 yr, body mass index = 23.8 2.2 kg·m −2 ) at a single time point matched uninjured controls 4 23.6 2.1 )....

10.1249/mss.0000000000002208 article EN Medicine & Science in Sports & Exercise 2019-12-06

Interactions among muscle strength, pain, and self-reported outcomes in patients with anterior cruciate ligament reconstruction (ACLR) are not well understood. Clarifying these interactions is of clinical importance because improving physical psychological function thought to optimize after ACLR. To examine the relationships neuromuscular quadriceps function, knee readiness return activity, emotional response injury both before Descriptive laboratory study. Twenty (11 females 9 males; age =...

10.4085/1062-6050-245-16 article EN Journal of Athletic Training 2018-04-01

ABSTRACT The study sought to determine the association between gait biomechanics (vertical ground reaction force [vGRF], vGRF loading rate [vGRF‐LR]) collected 6 months following anterior cruciate ligament reconstruction (ACLR) with patient‐reported outcomes at 12 ACLR. Walking and all subsections of Knee Injury Osteoarthritis Outcomes Score (KOOS) were ACLR, respectively, in 25 individuals a unilateral Peak peak instantaneous vGRF‐LR extracted from first 50% stance phase. Limb symmetry...

10.1002/jor.24056 article EN Journal of Orthopaedic Research® 2018-05-21

Objective To determine whether walking speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction ( ACLR ), is associated with inter‐extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, tibiofemoral articular cartilage . Methods Twenty‐one individuals a unilateral patellar‐tendon autograft (10 women 11 men, mean ± SD age 23.9 2.7 years, body mass index kg/m 2 ) were recruited for participation this study. Walking speed was...

10.1002/acr.23477 article EN Arthritis Care & Research 2017-11-29

ABSTRACT Purpose Determine the associations of body mass index (BMI) and composition (lean fat mass) with i ) patient-reported outcomes, ii quadriceps strength, iii physical performance in anterior cruciate ligament reconstruction (ACLR) patients. Methods Thirty-four individuals participated (56% female; 22 ± 4 years; % fat: 22.9 6.7%). Dual energy x-ray absorptiometry was used to measure percent lean (%LM) (%FM) for whole-body, whole-limb thigh region ACLR limb. Knee Injury Osteoarthritis...

10.1249/mss.0000000000003670 article EN Medicine & Science in Sports & Exercise 2025-02-10
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