A5026977716- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Minimally Invasive Surgical Techniques
- Uterine Myomas and Treatments
- Pregnancy-related medical research
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Diverticular Disease and Complications
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Urological Disorders and Treatments
- Colorectal Cancer Surgical Treatments
- AI in cancer detection
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Tissue Engineering and Regenerative Medicine
- Optical measurement and interference techniques
- Intestinal and Peritoneal Adhesions
- Urinary Tract Infections Management
- Brain Tumor Detection and Classification
- Electric Vehicles and Infrastructure
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
Obstetrics and Gynecology Hospital of Fudan University
2015-2024
Chang'an University
2024
Peking University
2017-2018
Illinois Institute of Technology
2015-2017
University of Chicago
2015
University of New Mexico
2015
Loyola University Medical Center
2015
Fudan University
2012-2013
Jiangyin People's Hospital
2010
Southeast University
2010
The present study was carried out to observe the impact of advanced glycation end products (AGEs) on collagen I derived from vaginal fibroblasts in context pelvic organ prolapse (POP), and explore downstream effects MAPK nuclear factor-κB (NF-κB) signaling. After treating primary cultured human (HVFs) POP non-POP cases with AGEs, cell counting by sulforhodamine B. expression levels I, receptor (RAGE), matrix metalloproteinase-1 (MMP-1) tissue inhibitor (TIMP-1) were detected western blot...
Abstract Objective To introduce our experience of robotic surgery reconstructive uterovaginal anastomosis and operative outcomes in congenital cervical vaginal atresia patients. Methods Clinical observation follow‐up four patients with who underwent reconstruction cervix vagina by SIS (small intestinal submucosa, SIS) graft. Results Average patient age was 13.8 ± 2.2. Patients complained severe periodic abdominal pain. Diagnosis made according to clinical characteristics, physical...
Abstract Background The transvaginal natural orifice transluminal endoscopic surgery (vNOTES) applied in gynecology has been developed recent years and evolving. In this study, we aimed to evaluate the feasibility effect of vNOTES hysterectomy for uterus ≥1 kilogram (kg). Methods From January 2019 March 2020, patients with benign indications cases weighing kg, underwent were studied retrospectively. patients’ demographics, surgery, operation outcomes follow-up details recorded. Results 39...
Abstract Background To describe the short-term outcomes of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for uterosacral ligament suspension (USLS) in patients with severe prolapse. Methods This was a retrospective study prolapse (≥ stage 3) who underwent vNOTES USLS between May 2019 and July 2020. The Pelvic Organ Prolapse Quantification (POP-Q) score, Prolapse/Urinary Incontinence Sexual Questionnaire short form (PISQ-12) Floor Inventory-20 (PFDI-20) were used to...
BACKGROUND Pelvic organ prolapse (POP) involves pelvic herniation into the vagina due to floor tissue laxity, and vaginal structure is an essential factor. In POP, walls exhibit abnormal collagen distribution decreased fibroblast levels functions. The intricate etiology of POP prohibition transvaginal meshes in reconstruction surgery present challenges targeted therapy development. Human umbilical cord mesenchymal stromal cells (hucMSCs) limitations, but their exosomes (hucMSC-Exo) are...
In spite of rapid growth in the use vaginally placed mesh pelvic reconstructive surgery, there are few reports on long-term efficacy and safety mesh-augmented repairs.To compare outcomes modified floor surgery with (MPFR) versus traditional anterior-posterior colporrhaphy (APC) for treatment organ prolapse (POP).This retrospective cohort study involved 158 women who underwent surgical management MPFR (n = 84) or APC 74) period between January 2007 June 2008. Main outcome measures included...
Previous studies by our group revealed that the phosphoinositide 3‑kinase (PI3K)/AKT pathway was involved in estrogen‑induced metastasis ovarian cancer cells. In present study, role and mechanism of invasion further explored using a stable short hairpin RNA (shRNA) estrogen receptor α/β (ER α/β) SKOV3 cell line when ER α β were knocked down lentiviral infection. The effects LY294002, PI3K inhibitor, on shRNA cells evaluated vitro vivo. 17‑β estradiol promoted invasion, activated...
Pelvic organ prolapse (POP) is a common degenerative disease among females. We previously reported that advanced glycation end products (AGEs), compounds derived from nonenzymatic glycoxidation reactions, accumulated in the human vaginal wall and impaired function of fibroblasts pathogenesis POP. This study investigated apoptosis induced by AGEs uterosacral ligament underlying mechanism.Human were cultured identified. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was...
This study establishes life cycle assessment model to quantitively evaluate and predict material resource consumption, fossil energy consumption environmental emissions of plug-in hybrid electric vehicles (PHEVs) by employing the GaBi software. envi-ronmental impact different vehicle working conditions, power battery degradation scenarios mileage on operation use stage PHEV, BEV HEV is distinguished. The findings indicate that under urban, highway, aggressive driving PHEVs' fuel...
The objective of this study was to evaluate the overall outcomes and complications transvaginal mesh (TVM) placement for management pelvic organ prolapse (POP) with different meshes a greater than 10-years follow-up.We performed retrospective review patients POP who underwent repair surgery (Prolift kit or self-cut Gynemesh) between January 2005 December 2010. Baseline patient characteristics were collected from patients' medical records. During follow-up, anatomical evaluated using...
Abstract Background Sacrocolpopexy is the gold standard treatment for apical prolapse. With development of minimally invasive surgical techniques, new approach transvaginal single-port laparoscopic sacrocolpopexy (TS-LSC) has become available. However, its therapeutic effects remain unclear. The aim this study to compare middle-term clinical outcomes with multi-port (LSC) Methods We conducted a retrospective cohort study. Patients advanced prolapse who underwent either TS-LSC or LSC between...
The altered behaviors and functions of pelvic floor fibroblasts are pathophysiological changes organ prolapse (POP). Our previous study showed that advanced glycated end products (AGEs) accumulated in the tissues POP induced fibroblast apoptosis. was designed to investigate whether quercetin antagonize AGEs-induced apoptosis functional inhibition fibroblasts. uptake 5-ethynyl-2'-deoxyuridine (EdU) evaluated for cell proliferation. Flow cytometric analysis applied Intracellular reactive...