A5082394591- Radioactivity and Radon Measurements
- Radioactive contamination and transfer
- Geology and Paleoclimatology Research
- Earthquake Detection and Analysis
- Nuclear Physics and Applications
- Geochemistry and Geologic Mapping
- Radioactive element chemistry and processing
- Geochemistry and Elemental Analysis
- Nuclear and radioactivity studies
- Heavy metals in environment
- Geological and Geochemical Analysis
- earthquake and tectonic studies
- Isotope Analysis in Ecology
- Cell death mechanisms and regulation
- Methane Hydrates and Related Phenomena
- Archaeology and ancient environmental studies
- Pacific and Southeast Asian Studies
- Ubiquitin and proteasome pathways
- Nanoparticle-Based Drug Delivery
- Water Quality and Pollution Assessment
- Computational Drug Discovery Methods
- Seismology and Earthquake Studies
- Analytical chemistry methods development
- Lichen and fungal ecology
- Cultural Heritage Materials Analysis
Granta Design (United Kingdom)
2017-2024
Applied Research Associates
2015
Hutt Hospital
1994-2009
Hiroshima University
2007-2008
GNS Science
1994-2006
Kanazawa University
2004
Osaka University
2004
Hacettepe University
2004
Acadia University
1998
International Atomic Energy Agency
1994
Escape from apoptosis is one of the major hallmarks cancer cells. The B-cell Lymphoma 2 (BCL-2) gene family encodes pro-apoptotic and anti-apoptotic proteins that are key regulators apoptotic process. Overexpression pro-survival member BCL-2 a well-established mechanism contributing to oncogenesis chemoresistance in several cancers, including lymphoma leukemia. Thus, has become an attractive target for therapeutic strategy cancer, as demonstrated by recent approval ABT-199 (Venclexta™)...
We describe our work to establish structure- and fragment-based drug discovery identify small molecules that inhibit the anti-apoptotic activity of proteins Mcl-1 Bcl-2. This identified hit series compounds, some which were subsequently optimized clinical candidates in trials for treating various cancers. Many protein constructs designed with suitable properties different biophysical assays structural methods. Fragment screening using ligand-observed NMR experiments several compounds each...
// Patrick Casara 1, * , James Davidson 2, Audrey Claperon 3, Gaëtane Le Toumelin-Braizat 3 Meike Vogler 4 Alain Bruno 5 Maïa Chanrion Gaëlle Lysiak-Auvity Thierry Diguarher 1 Jérôme-Benoît Starck Ijen Chen 2 Neil Whitehead Christopher Graham Natalia Matassova Pawel Dokurno Pedder Youzhen Wang 6 Shumei Qiu Anne-Marie Girard Emilie Schneider Fabienne Gravé Aurélie Studeny Ghislaine Guasconi Francesca Rocchetti Sophie Maïga 7 Jean-Michel...
The New Zealand Kaikoura Earthquake (Mw 7.8, 14 November 2016) produced co-seismic flashes of earthquake light near the ground at midnight, 230 km north epicentre. Mostly, there was a white hemisphere in atmosphere just above ground, up to 250 m radius, colour becoming radially increasingly dark blue. Fifteen videos were available for analysis which led following new or reaffirmed conclusions: (i) blue is due Rayleigh Scattering (new explanation); (ii) also sometimes occurs within low clouds...
Aquatic bryophytes growing in streams were used for biogeochemical prospecting uranium the Buller Gorge area of New Zealand. Alpha radioactivity was found to bear an inverse relationship content many bryophytes. The concentration this element gave approximately quantitative indication mineralization and correlated well with waters. Bryophytes have sometimes been search minerals but they mainly as geobotanical indicators using such plants known copper mosses which are said grow preferentially...
Libraries of nonpurified resorcinol amide derivatives were screened by surface plasmon resonance (SPR) to determine the binding dissociation constant (off-rate, kd) for compounds pyruvate dehydrogenase kinase (PDHK) enzyme. Parallel off-rate measurements against HSP90 and application structure-based drug design enabled rapid hit lead progression in a program identify pan-isoform ATP-competitive inhibitors PDHK. Lead optimization identified selective sub-100-nM enzyme which significantly...
The origin of soils on Niue Island, an uplifted South Pacific former atoll, has long been a subject debate because the are highly radioactive. A new assessment proposed sources shows that content in major elements such as Fe and Al rules out erosion carbonate buildup or pristine aragonite coral. Subaerial volcanic ash previously argued to be source according newly employed diagnostic ratio Fe2O3/Al2O3 it is confirmed definite minor contributor. ratios offer evidence most likely soil...
The maternal immune hypothesis (MIH) argues same sex attraction (SSA) results from attack on fetal male-specific brain structures and involves the previous biological influence of elder brothers. One surveys supporting this is shown to be based an unsuitable sample contain some strong contrary evidence. relies at least four speculative ideas there evidence against each. (1) Likely response prevalence too low compared with calculated SSA resulting fraternal birth order effect. (2) Testis...
<p>Earthquake light (EQL) mainly blue-white flashes from the ground, was observed coseismically during a NewZealand M7.1 earthquake, (4.47 am 4-Sep-2010 local time). A production mechanism is most probable. The flash observations support Freund et al. mechanism, i.e. shockwave disturbance creating electronic“holes” ruptured peroxy bonds in quartz, and subsequent surface positive charge followed by emission neutralization. Examination of video records shows median length about half...
Abstract The major and trace element contents of 241 Niue Island lateritic soils were determined, mainly by X‐ray fluorescence, to deduce soil origins. analyses showed very low SiO2 content, a high content Mg, P, V, Cr, Sr, Y, Hg, α‐counts, compared with other laterites worldwide. distribution patterns are consistent derivation weathering from calcite dolomite rather than deposited volcanic ash. Weathering is particularly novel explanation for the origin relatively P in these soils. contain...
Abstract. Previous published work after the Kobe and İzmit earthquakes (1995 1999, respectively) demonstrated some reported meteorological animal behaviour precursors were valid. Predictions freshly tested for Christchurch earthquake (M = 7.1, 4 September 2010). An internet survey with nearly 400 valid replies showed relative numbers of reports in precursor categories day before quake, statistically significantly different from those preceding three days (excess events behaviour). The there...
Abstract Dentine samples of 50 mg were drilled from the pulp cavity region human incisors a series burials on Polynesian outlier Taumako in Solomon Islands. Electron spin resonance (ESR) spectra obtamed, and height peak near g = 2.002 compared with that for an internal ruby standard was used dating purposes. The 15 archaeological specimens fit into tight chronological sequence, age burial ground dated by radiocarbon to A.D. 153 ‡ years. Where independent stratigraphic information exists...