A5023067579- Trypanosoma species research and implications
- RNA modifications and cancer
- Vector-Borne Animal Diseases
- Biochemical and Molecular Research
- Research on Leishmaniasis Studies
- Insect symbiosis and bacterial influences
- Viral-associated cancers and disorders
- Complement system in diseases
- T-cell and Retrovirus Studies
University of Würzburg
2021-2023
University of Ghana
2017-2022
Animal African trypanosomiasis (AAT) greatly affects livestock production in sub-Saharan Africa. In Ghana prevalence of AAT is estimated to range between 5 and 50%. Studies have reported serum biochemical aberrations variability cytokine profiles animals during infection. However, information regarding the parameters associated with natural infections are limited. This study was therefore aimed at investigating changes levels inflammatory cytokines a infection.Nested internal transcribed...
Background Animal African Trypanosomiasis (AAT) is one of the most economically important diseases affecting livestock productivity in sub-Saharan Africa. The disease caused by a broad range Trypanosoma spp., infecting both wild and domesticated animals through cyclical mechanical transmission. This study aimed to characterize trypanosomes present cattle at regular intervals over two years an AAT endemic non-endemic region Ghana. Methodology/Principal findings Groups Accra Adidome were...
The biosynthesis of ribosomes is a complex cellular process involving ribosomal RNA, proteins and several further trans-acting factors. DExD/H box constitute the largest family protein factors involved in this process. Several members have been directly implicated ribosome biogenesis yeast. In trypanosomes, differs features from described Here, we identified helicase Hel66 as being biogenesis. unique to Kinetoplastida, localises nucleolus its depletion via RNAi caused severe growth defect....
Abstract The cell surface of bloodstream form African trypanosomes is covered by a dense coat immunogenic variant glycoproteins (VSGs). By continuously changing the expressed VSG antigen, parasites can survive host’s immune response. highly in Trypanosoma brucei , accounting for approximately 10 – 20% total mRNA. Depletion mRNA lethal, and counterbalancing levels occurs when two or more VSGs are simultaneously expressed. How expression regulated unknown. Here, using inducible constitutive...
ABSTRACT The biosynthesis of ribosomes is a complex cellular process involving ribosomal RNA, proteins and several further trans-acting factors. DExD/H box constitute the largest family protein factors involved in this process. Several members have been directly implicated ribosome biogenesis yeast. In trypanosomes, differs features from described Here, we identified helicase Hel66 as being biogenesis. unique to Kinetoplastida, localises nucleolus its depletion via RNAi caused severe growth...
Abstract The variant surface glycoprotein (VSG) of African trypanosomes is essential for survival bloodstream form parasites. These parasites undergo antigenic variation, an immune evasion strategy in which they periodically switch VSG expression from one isoform to another. molecular processes central the and regulation are however not fully understood. In general, gene largely post-transcriptional. Regulatory sequences, mostly present 3’ UTRs, often serve as key elements modulation levels...
Abstract The biosynthesis of ribosomes is a complex cellular process involving ribosomal RNA, proteins and several further trans-acting factors. DExD/H box constitute the largest family protein factors involved in this process. Several members have been directly implicated ribosome biogenesis yeast. In trypanosomes, differs features from described Here, we identified helicase Hel66 as being biogenesis. unique to Kinetoplastida, localises nucleolus its depletion via RNAi caused severe growth...