A5005590996- Pneumonia and Respiratory Infections
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Neonatal and Maternal Infections
- Essential Oils and Antimicrobial Activity
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Oral microbiology and periodontitis research
- Enzyme Structure and Function
- Pregnancy and preeclampsia studies
- Phytochemistry and Bioactivity Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes and associated disorders
- Streptococcal Infections and Treatments
University of Mosul
2017-2022
University of Leicester
2015-2017
Pneumococcal neuraminidase is a key enzyme for sequential deglycosylation of host glycans, and plays an important role in survival, colonization, pathogenesis infections caused by Streptococcus pneumoniae. One the factors that can affect activity amount position acetylation present its substrate sialic acid. We hypothesised pneumococcal esterases potentiate removing from acid, will have major effect on survival mucin, virulence. These hypotheses were tested using isogenic mutants recombinant...
Abstract In this study, 15 isolates of Escherichia coli were isolated from patients with urinary tract infections Al-Khansa'a Teaching Hospital Mosul /Iraq May 2023 till July 2023. The studied and diagnosed biochemically. result microscopic tests showed that are short Gram-negative bacilli, the biochemical was positive for catalase, triple sugar iron, indole, methyl red, coagulation enzyme, fermentation following sugars maltose, sucrose, galactose glucose, while negative results urease,...
Abstract Catabolism of galactose by Streptococcus pneumoniae alters the microbe’s metabolism from homolactic to mixed acid fermentation, and this shift is linked virulence. However, genetic basis switch unknown. Pyruvate formate lyase (PFL) a crucial enzyme for fermentation. Functional PFL requires activities two enzymes: pyruvate activating (coded pflA ) pflB ). To understand transcriptional regulation was studied. By microarray analysis Δ , differential several regulators were identified,...
For the generation of energy, important human pathogen Streptococcus pneumoniae relies on host-derived sugars, including β-glucoside analogs. The catabolism these nutrients involves action 6-phospho-β-glucosidase to convert them into usable monosaccharaides. In this study, we characterized a (BglA3) encoded by SPD_0247. We found that enzyme has cell membrane localization and is active only against phosphorylated substrate. A mutated pneumococcal ΔSPD0247 strain had reduced...
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has become the most dangerous viral infection worldwide. Since its identification in late 2019, number of medical trials to combat sharply increased. Here, we investigated profiles IgG and IgM 85 patients with confirmed SARS-CoV-2 from day 1 after symptom onset until 35 5-day intervals. Serum samples were collected stored use. We observed that levels detectable on 5 post increased sharply, highest rate...
Pseudomonas aeruginosa is one of the most life-threatening pathogen. It considered nosocomialopportunistic microbe that cause wide range infections including wound and burn infections, respiratoryinfections, Otitis media. Despite efficiency antibiotics against infectious diseases, P. aeruginosastill causes complicated with antibiotic resistance in many clinical strains. The pigments producedby exhibits antibacterial properties. Thus, we have examined its ability to enhance antibioticseffect...
Abortion is considered as one of the major problems in women which can lead to termination fertility.Most abortion cases are directly linked with TORCH complex or congenital infections including bacterial, viral, and protozoal infections.Here, we collected 109 serum samples from pregnant (study group) 64 nonpregnant (control group).The were examined for presence anti-TORCH-IgM anti-TORCH-IgG antibodies against using enzyme-linked immunosorbent assay (ELISA) technique.Out study group, 51...
Streptococcus pluranimalium was first isolated in 1999. Recently, several case reports have been published that revealed S. can infect humans as well. The pathogenicity and pathophysiology of this pathogen is poorly studied its characteristics are not well known. In study, then identified from infants children who suffered upper respiratory infections. 90 samples were collected nasopharyngeal cavity. Among them, 83 spp. isolates identified. 3 out which biochemically molecularly...