A5102782168- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Gastroesophageal reflux and treatments
- CRISPR and Genetic Engineering
- Protein Tyrosine Phosphatases
- Cancer and Skin Lesions
- Epigenetics and DNA Methylation
- Cerebral Venous Sinus Thrombosis
- Sports injuries and prevention
- Cardiac pacing and defibrillation studies
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- DNA Repair Mechanisms
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- RNA regulation and disease
- Tendon Structure and Treatment
- Immune cells in cancer
- Migraine and Headache Studies
- Nonmelanoma Skin Cancer Studies
- Cerebrovascular and Carotid Artery Diseases
- Ear and Head Tumors
University of Cyprus
2024
Autolus (United Kingdom)
2018-2023
University of Zurich
2023
AstraZeneca (United Kingdom)
2021
University of Crete
2017
Barts Health NHS Trust
2016
Royal London Hospital
2016
University College London
2015
North Central College
2013
Lister Hospital
2012-2013
Engineered T cell therapies show considerable promise in the treatment of refractory malignancies. Given ability engineered cells to engraft and persist for prolonged periods along with unpredicted toxicities, incorporation a suicide gene allow selective depletion after administration is desirable. Rapamycin safe widely available immunosuppressive pharmaceutical that acts by heterodimerization FKBP12 FRB fragment mTOR. The apical caspase 9 activated homodimerization through its CARD domain....
Abstract DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether how IFN signaling in turn impacts the process has remained elusive. Here we show that basal levels of IFN-stimulated gene 15, ISG15, its conjugation (ISGylation) are essential to protect nascent from degradation. Moreover, IFNβ treatment restores fork stability BRCA1/2-deficient cells, which strictly depends on topoisomerase-1, rescues lethality...
Abstract Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. Here we compare intracellular traffic of anti KRAS oligonucleotide (AZD4785) cell lines PC9 LK2, with good uptake, respectively. We find that the majority AZD4785 is rapidly delivered to CD63+late endosomes (LE) both lines. Importantly, lysobisphosphatidic acid (LBPA)...
SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs ITSMs on immune receptors. Consequently, key in the transmission of signals within T cells, constituting an important point convergence for diverse Therefore, inhibition may represent a strategy preventing immunosuppression cells mediated by cancers hence improving immunotherapies directed against these malignancies. Both contain dual domains responsible...
Perianal extra-mammary Paget's disease is a rare skin disorder of unknown aetiology, which frequently associated with malignancy. This case report draws attention to this condition and comments upon its diagnosis treatment.A 64-year-old otherwise fit man, presented us in 2006 one-year-long history perianal irritation. On examination there was an erythematous discoid lesion the right area. The excised wide margins defect closed local transposition flap. Histology confirmed (EMPD) focus...
Objective. Heart failure remains a major cause of morbidity and mortality. Given that heart generally has chronic course, it is important to appreciate the impact can have on quality life patients also their partners or family carers. Method. Questionnaires were given patient newly diagnosed with dilated cardiomyopathy, during his hospital admission, as well after discharge. The responses are summarised explored in discussion section, where we used review literature discuss implications new...
<h3>Introduction</h3> Nissen9s fundoplication for gastro-oesophageal reflux disease provides good long term control of acid but is often not without unwanted side-effects. We investigated outcome at our centre. <h3>Methods</h3> Study group included 100 patients who underwent from 2005 to 2011 unit. Pre-operative demographics, symptom profile, investigations and operative data were reviewed. Symptoms after surgery (heartburn, dysphagia, bloating excessive flatus), antacid usage patient...
Abstract Adoptive transfer of antigen specific regulatory T (Treg) cells was shown to be beneficial for the suppression autoimmunity and Graft versus Host Disease (GvHD). To create a cellular regimen targeted unwanted immune responses, we engineered mouse MHC-class II Treg-like cells. The restricted expression MHCII professional presenting presence at high levels all inflammatory sites, allow employment in various settings. A MHCII-specific Chimeric Antigen Receptor (CAR) used redirect...
A 20 year old woman with a history of migraine visual aura in the form both positive (fortification spectrum) and negative features was admitted to hospital because unilateral pulsatile right sided headache one day’s duration. The associated photophobia, intense nausea vomiting, facial upper arm numbness, temporal field defect. She described as similar her habitual migraines character but “the worst ever.” On examination she normotensive Glasgow coma scale 15. neurological defect confirmed...
Abstract SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs ITSMs on immune receptors. Consequently, key in the transmission of signals within T cells, constituting an important point convergence for diverse Therefore, inhibition may represent a strategy preventing immunosuppression cells mediated by cancers hence improving immunotherapies directed against these malignancies. Both contain dual domains responsible...
<h3>Introduction</h3> To review the long-term efficacy of Laparoscopic Heller9s Cardiomyotomy in patients with Achalasia Cardia at a large UK District General Hospital. <h3>Methods</h3> A structured postal survey was undertaken on 40 consecutive clinical, radiologic, endoscopic and manometric diagnosis who underwent by single surgeon our unit between 1996 2011. The procedure supplemented Anterior Fundoplication all patients. <h3>Results</h3> average age study group 49 years (range 18–80...