A5020631192- Endometrial and Cervical Cancer Treatments
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Molecular Biology Techniques and Applications
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
Institute of Medical Sciences
2023-2024
King George's Medical University
2022-2023
Background: Endometrioid endometrial carcinoma is one of the most prevalent gynecologic cancers. The epithelial-mesenchymal transition a multistep process involved in development cells that results disappearance intercellular adhesion epithelium and acquiring mesenchymal properties, hence influence cancer progression metastasis. Loss can be activated by different mechanisms, including transcriptional repression. However, expression repressors EEC precursor lesions remain to investigated. In...
Gargi Tignath Shukla, Sunita Yadav, Ajay Krishna Kumar Amit V. Varma, Sirish Nandedekar, Mili Senger and Sudha Gupta. Korean J Gastroenterol 2024;84:153-9. https://doi.org/10.4166/kjg.2024.063
ObjectivesEndometrial carcinoma (EC), majority being endometroid endometrial (EEC), is the most common invasive gynecological cancer world-wide. Epithelial mesenchymal transition (EMT) process that cells undergo to switch from a polarized epithelial phenotype motile phenotype. Loss of E-cadherin and expression N-cadherin are critical step for development progression malignant tumors. In present study we evaluated immunohistochemical (IHC) with clinicopathological parameters EEC its...
Endometrioid endometrial carcinoma (EEC) is most common invasive malignancy of female genital tract. In spite advances in diagnosis and treatment, incidence EEC has been rising because increasing aging population prevalence obesity. Therefore, there need research exploring the underlying molecular mechanism its precursors. Wnt/ β-catenin signaling are involved progression invasion EEC. However, potential role effectors cancer precursor lesions remains to be investigated. present study a...
Endometrioid endometrial carcinoma (EEC) is the most common invasive malignancy of female genital tract. Despite advances in diagnosis and treatment, incidence EEC mortality related to it have not decreased. Therefore, research needed explore underlying molecular mechanisms its precursors reduce societal burden associated with them. Phosphatase tensin homolog (PTEN) a tumor suppressor gene commonly altered precursor lesions. Promoter methylation mechanism for inactivation PTEN gene.This was...