A5078118692- Ovarian function and disorders
- Reproductive Biology and Fertility
- Hypothalamic control of reproductive hormones
- Estrogen and related hormone effects
- Regulation of Appetite and Obesity
- Lipid metabolism and disorders
- Birth, Development, and Health
- Ovarian cancer diagnosis and treatment
- Phytochemistry and biological activities of Ficus species
- Sexual Differentiation and Disorders
Shiraz University
2018-2023
An abnormality in pulse amplitude and frequency of gonadotropin releasing hormone (GnRH) secretion is the most characteristics polycystic ovarian syndrome (PCOS). On other hand, arginine-phenylalanine-amide (RFamide)-related peptide-3 (RFRP3) inhibits GnRH mammalian hypothalamus. The current study performed order to investigate expression RFRP3 mRNA dorsomedial hypothalamic nucleus (DMH) after induction PCOS a rat model constant light exposure, possible role parity on occurrence PCOS.In...
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder associated with irregular menstrual cycles, hyperandrogenism, obesity, and reduced fertility. Objectives: The present study aimed to formulate herbal syrup based on Iranian traditional medicine (ITM) evaluate its effect the letrozole-induced PCOS model in female rats. Methods: contains anise, fennel, celery seed extracts. Five different formulations were made percentages of additive components. Quality control...
Hypothalamic Melanocortin-4Receptor (MC4R) and kiss1/kisspeptin systems play roles in reproductive processes. This study was conducted to evaluate changes MC4R kiss1 genes expression the arcuate nucleus (ARC) of hypothalamus its relationship with polycystic ovary syndrome (PCOS) rats.In current experimental study, 24 female rats were randomly equally allocated into nulliparous primiparous groups then divided two subgroups PCOS control. induced by exposure continuous light. Sex-related...
Background: Hypothalamic Melanocortin-4 Receptor (MC4R) and kiss1/kisspeptin systems play roles in reproductive processes. This study was conducted to evaluate changes MC4R kiss1 genes expression the arcuate nucleus (ARC) of hypothalamus its relationship with polycystic ovary syndrome (PCOS) rats.Materials Methods: In current experimental study, 24 female rats were randomly equally allocated into nulliparous primiparous groups then divided two subgroups PCOS control. induced by exposure...
Intrauterine endocrine abnormalities have profound effects on the development of physiological disorders.This study aimed to assess in utero exposure letrozole (an aromatase inhibitor) and its late consequences reproductive metabolic performance an adult male offspring.15 pregnant Sprague-Dawley rats (8 wk, 155 gr) were randomly assigned into 5 experimental groups (n = 3/each) orally received either at doses 0.25, 0.75, 1.00, 1.25 mg/kg body weight (BW) or vehicle (control) gestation days...
Despite prevalence of polycystic ovary syndrome (PCOS) among childbearing women and development many animal models for this syndrome, information on its etiology is still scarce. The intrauterine hyperandrogenic environment may underlie changes at the level hypothalamus, pituitary, organization in female offspring, PCOS later life. Letrozole has been shown to mimic reproductive metabolic characteristics adult rodent models. Therefore, research aimed assess condition a prenatal...
Abstract Despite the prevalence of polycystic ovary syndrome (PCOS) among childbearing women and development many animal models for this syndrome, information on its etiology is still scarce. Intrauterine hyperandrogenic environment may underlie changes at levels hypothalamus, pituitary organization in female offspring, PCOS later life. Letrozole, has been shown to mimic reproductive metabolic characteristics adult rodent models. Therefore, aim research was assess condition a prenatal...
Background: Hypothalamic Melanocortin-4 Receptor (MC4R) and kiss1/kisspeptin systems play roles in reproductive processes. This study was conducted to evaluate changes MC4R kiss1 genes expression the arcuate nucleus (ARC) of hypothalamus its relationship with polycystic ovary syndrome (PCOS) rats. Materials Methods: In current experimental study, 24 female rats were randomly equally allocated into nulliparous primiparous groups then divided two subgroups PCOS control. induced by exposure...
Abstract Background: Despite the prevalence of polycystic ovary syndrome (PCOS) among childbearing women and development many animal models for this syndrome, information on its etiology is still scarce. Intrauterine hyperandrogenic environment may underlie changes at levels hypothalamus, pituitary organization in female offspring, PCOS later life. Letrozole, has been shown to mimic reproductive metabolic characteristics adult rodent models. Therefore, aim research was assess condition a...