A5020544245- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Electrochemical Analysis and Applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Invertebrate Immune Response Mechanisms
- Coordination Chemistry and Organometallics
- Force Microscopy Techniques and Applications
Zhejiang University
2022-2025
Interface (United Kingdom)
2025
Zhejiang Lab
2024
Sir Run Run Shaw Hospital
2022
Insects rely on a family of seven transmembrane proteins called gustatory receptors (GRs) to encode different taste modalities, such as sweet and bitter. We report structures
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize membrane potential. KCNQ2 can be activated by analgesics and antiepileptic drugs but their activation mechanisms remain unclear. Here we report cryo-electron microscopy (cryo-EM) structures of KCNQ2-CaM in complex with three activators, namely drug cannabidiol (CBD), lipid phosphatidylinositol 4,5-bisphosphate (PIP2), HN37 (pynegabine), an clinical trial, either closed or open...
The cardiac KCNQ1 potassium channel carries the important I Ks current and controls heart rhythm. Hundreds of mutations in can cause life-threatening arrhythmia. Although structures have been recently resolved, structural basis for dynamic electro-mechanical coupling, also known as voltage sensor domain–pore domain (VSD-PD) remains largely unknown. In this study, utilizing two VSD-PD coupling enhancers, namely, membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP 2 ) a small-molecule...
The human voltage-gated potassium channels KCNQ2, KCNQ3, and KCNQ5 can form homo- heterotetrameric that are responsible for generating the neuronal M current maintaining membrane potential stable. Activation of KCNQ requires both depolarization phosphatidylinositol 4,5-bisphosphate (PIP 2 ). Here, we report cryoelectron microscopy structures KCNQ5–calmodulin (CaM) complex in apo, PIP -bound, - activator HN37-bound states either a closed or an open conformation. In conformation, molecule...