A5071656590- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiomics and Machine Learning in Medical Imaging
- Trauma Management and Diagnosis
- Esophageal and GI Pathology
- Airway Management and Intubation Techniques
- Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Cardiac tumors and thrombi
- Respiratory Support and Mechanisms
- Colorectal Cancer Treatments and Studies
- Foreign Body Medical Cases
- Sarcoma Diagnosis and Treatment
- Dysphagia Assessment and Management
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Cancer survivorship and care
- Pneumothorax, Barotrauma, Emphysema
- Immune Response and Inflammation
University of Tsukuba
2016-2025
Hitachi General Hospital
2016-2025
University of Tsukuba Hospital
2000-2025
Hitachi (Japan)
2017-2021
Tsukuba Medical Center Hospital
2006-2018
Ibaraki University
2010
Regional Cancer Center
2008
Columbia University
2001-2007
St. Luke's-Roosevelt Hospital Center
2001-2007
Institute of Clinical Research
2004
Elevation of lung capillary pressure causes exocytosis the leukocyte adhesion receptor P-selectin in endothelial cells (ECs), indicating that ECs generate a proinflammatory response to pressure-induced stress. To define underlying mechanisms, we followed EC signaling sequence leading through application real-time, situ fluorescence microscopy capillaries. Pressure elevation increased amplitude cytosolic Ca(2+) oscillations triggered increases mitochondrial and reactive oxygen species (ROS)...
To evaluate the effectiveness of lung cancer screening using low-dose computed tomography for general population, we conducted a retrospective cohort study participants among Hitachi residents.Citizens aged 50-74 who underwent at least once during 1998-2006 were defined as group, and those X-ray same period, but did not receive throughout follow-up XP group. We investigated incidence rate, mortality rate all-cause both groups from first to end 2012.In group (17 935 residents; 9790 males 8145...
Many patients with lung cancer have been cured by surgical intervention. However, the long-term effects of resection on pulmonary function are unclear. Therefore, we investigated after surgery.We retrospectively reviewed medical records who underwent surgery for between 2001 and 2009. A total 445 had survived more than 5 years since were included. The divided into lobectomy, segmentectomy partial groups. time-dependent changes in investigated.The percentages vital capacity forced expiratory...
Left upper lobectomy may be followed by complications such as thrombus formation in a stump of the left superior pulmonary vein (LSPV), which cause systemic embolization. We have encountered four cases, account for 3.4% all lobectomies performed at our institution. Right renal infarction was observed one these cases; remaining cases were asymptomatic, with incidentally detected enhanced computed tomography (CT). The postoperative duration detection varied from 4 days to 24 months. Even case...
Although capillary barrier deterioration underlies major inflammatory lung pathology, barrier-enhancing strategies are not available. To consider hyperosmolar therapy as a possible strategy, we gave 15-minute infusions of sucrose in venular capillaries imaged real time. Surprisingly, this treatment enhanced the barrier, indicated by quantification hydraulic conductivity. The enhancement was sufficient to block injurious effects thrombin, TNF-α, and H2O2 single capillaries, intratracheal acid...
Abstract Cytokine-induced lung expression of the endothelial cell (EC) leukocyte receptor P-selectin initiates rolling. To understand early EC signaling that induces expression, we conducted real-time digital imaging studies in venular capillaries. compare receptor- vs nonreceptor-mediated effects, infused capillaries with respectively, TNF-α and arachidonate. At concentrations adjusted to give equipotent increases cytosolic Ca2+, both agents increased reactive oxygen species (ROS)...
Real-world data on the clinical outcomes of first-line osimertinib treatment for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations is lacking. This study aimed to reveal and prognostic factors as therapy in practice settings.We retrospectively evaluated patients EGFR-mutated NSCLC treated across 12 institutions Japan between August 2018 March 2020.Among 158 enrolled patients, objective response rate (ORR) was 68%, estimated median progression-free...
Abstract Purpose Pleural adhesions, which may be present in varying degrees and involve blood vessels, often complicate thoracic surgery. The flow within pleural adhesions can identified on computed tomography (CT) as micro-vessels beneath the surface (MVBP). We conducted a prospective study to assess if MVBP detected preoperative CT predict intraoperative adhesions. Methods This investigated images of patients scheduled undergo surgery for lung tumors. was defined positive when vessels were...
Although clusters of alveoli form the acinus, which is most distal respiratory unit, it not known whether interalveolar communication coordinates acinar surfactant secretion. To address this, we applied real-time digital imaging in conjunction with photo-excited Ca 2+ uncaging intact isolated, blood-perfused rat lung. We loaded alveolar cells cage o-nitrophenyl EGTA-AM (NP-EGTA-AM) together fluorophores, fluo 4, or LysoTracker green (LTG) to determine, respectively, cytosolic concentration...
Although alveoli clear liquid by active transport, the presence of surface-active material on alveolar surface suggests that convective mechanisms for rapid removal may exist. To determine such mechanisms, we held isolated blood-perfused rat lung at a constant pressure (Pa). Under videomicroscopy, micropunctured single alveolus to infuse saline or Ringer solution in ∼10 adjacent alveoli. Infused were lost from view. However, as infused cleared, reappeared and their diameters could be...
Aim: To describe the prevalence and determinants of acquired epidermal growth factor receptor (EGFR) T790M gene mutation in a clinical practice setting. Materials Methods: We performed retrospective chart review study between January 2013 November 2017 across multiple institutes, covering population 3 million people. Results: reviewed charts 233 patients non-small cell lung cancer with EGFR mutations. Of them, 99 (42.5%) had mutations EGFR. Patients ≥75 years old an exon 19 deletion higher...
Abstract Background The preoperative predictors of quality life (QOL) in patients who undergo lung resection for cancer are poorly known. Here, we investigated these such using two QOL measures. Methods In this single‐institutional prospective cohort study, administered the EQ‐5D‐5 levels (EQ‐5D‐5L) from January 2015, and European Organization Research Treatment Cancer (EORTC) Quality Life Questionnaire with 30 items April 2015 to 2018 preoperatively (Pre) at one month postoperatively (M1),...
Older persons can be susceptible to respiratory-related conditions, particularly pneumonia.This study examined the effects of breathing training on respiratory function, swallowing and quality life in community-dwelling frail older with musculoskeletal disorders.The participants were divided into 2 groups.One group performed a regular rehabilitation programme, other exercises, including coughing exercise, muscle stretching using hand-held resistance device.The exercises improved swallowing,...
The presence of mediastinal lymph node metastasis is important because it related to the treatment and prognosis lung cancer. Although prevalently used, evaluation nodes not always reliable. We introduced sphericity as a criterion for evaluating morphologic differences between metastatic nonmetastatic nodes.We reviewed cases 66 patients with N2 disease 68 N0-1 who underwent lobectomy dissection January 2012 December 2021. dissected station nodes, which represents how close being true sphere,...
Although pressure elevation in lung postcapillary venules increases endothelial P-selectin expression, the extent to which causes leukocyte margination remains controversial. To address this issue, we optically viewed of isolated blood-perfused rat by real-time fluorescence imaging. determine single venules, quantified leukocytes labeled situ with rhodamine 6G (R6G). baseline was sparse, a 10-min 10 cmH(2)O markedly increased R6G fluorescence. Both stopping blood flow during and eliminating...
The incidence and mortality of lung cancer have increased worldwide over the last decades, with an observed particularly among elderly populations. It has not yet been determined whether erlotinib therapy exhibits same efficacy safety in younger patients non-small-cell (NSCLC). aim this retrospective subgroup analysis data from a population-based observational study was to assess (≥75 years, n=74) group (<75 n=233) who received treatment for NSCLC. time failure similar [median, 62 days; 95%...
Pulmonary papillary adenoma is a benign pulmonary neoplasm. Previously was described in terms of immunohistochemistry and ultrastructure. However, there are no previous reports describing the cytologic characteristics adenoma.A 50-year-old male admitted for evaluation coin lesion left upper lung field. Radiologic images showed solid, round tumor approximately 25 mm diameter lung. Transbronchial needle aspiration biopsy (TBNA) performed, small numbers atypical cells were collected....
Background/Aim: To describe real clinical outcomes in patients with non-small cell lung cancer who have uncommon epidermal growth factor receptor (EGFR) mutations. Materials and Methods: We performed a retrospective chart review from 15 medical institutes that cover population of three million people April 2008 to March 2019. Results: There were 102 EGFR mutation. Progression-free survival (PFS) tended be longer receiving afatinib compared first-generation tyrosine kinase inhibitors. PFS...