A5012365458- Immune cells in cancer
- Inflammasome and immune disorders
- Genetics, Aging, and Longevity in Model Organisms
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Immune Response and Inflammation
- Cellular transport and secretion
- Phagocytosis and Immune Regulation
- Photoreceptor and optogenetics research
- Single-cell and spatial transcriptomics
- Adipokines, Inflammation, and Metabolic Diseases
- CRISPR and Genetic Engineering
Ludwig-Maximilians-Universität München
2022-2025
Istituto Superiore di Sanità
2021-2023
Common genetic variants in a conserved cis-regulatory element (CRE) at histone deacetylase (HDAC)9 are major risk factor for cardiovascular disease, including stroke and coronary artery disease. Given the consistency of this association its proinflammatory properties, we examined mechanisms whereby HDAC9 regulates vascular inflammation. bound mediated deacetylation NLRP3 NACHT LRR domains leading to inflammasome activation lytic cell death. Targeted deletion critical CRE mice increased Hdac9...
Dominant GNAO1 mutations cause an emerging group of childhood-onset neurological disorders characterized by developmental delay, intellectual disability, movement disorders, drug-resistant seizures and deterioration. encodes the α-subunit inhibitory GTP/GDP-binding protein regulating ion channel activity neurotransmitter release. The pathogenic mechanisms underlying GNAO1-related remain largely elusive there are no effective therapies. Here, we assessed functional impact two disease-causing...
Innate immune pathways play a crucial role in the development of atherosclerosis, from sensing initial danger signals to long-term reprogramming cells. Despite success lipid-lowering therapy, anti-hypertensive medications, and other measures reducing complications associated with cardiovascular disease (CVD) remains leading cause death worldwide. Consequently, there is an urgent need devise innovative preventive therapeutic strategies alleviate global burden CVD. Extensive experimental...
De novo CLTC mutations underlie a spectrum of early-onset neurodevelopmental phenotypes having developmental delay/intellectual disability (ID), epilepsy, and movement disorders (MD) as major clinical features. encodes the widely expressed heavy polypeptide clathrin, component coated vesicles mediating endocytosis, intracellular trafficking, synaptic vesicle recycling. The underlying pathogenic mechanism is largely unknown. Here, we assessed functional impact recurrent c.2669C > T...