A5046064649- Evolution and Genetic Dynamics
- Plant Reproductive Biology
- Plant and animal studies
- Genetic Mapping and Diversity in Plants and Animals
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Plant Molecular Biology Research
- HIV/AIDS drug development and treatment
- Genetic diversity and population structure
- Genetic Associations and Epidemiology
- Gene Regulatory Network Analysis
University of Bern
2024-2025
Max Planck Institute for Plant Breeding Research
2023
University of Konstanz
2012
The capability of DNA polymerases to accept chemically modified nucleotides is paramount importance for many biotechnological applications. Although these analogues are widely used, the structural basis acceptance unnatural nucleotide surrogates has been only sparsely explored. Here we present in total six crystal structures 2'-deoxynucleoside-5'-O-triphosphates (dNTPs) carrying modifications at C5 positions pyrimidines or C7 7-deazapurines complex with a polymerase and primer/template...
We study natural DNA polymorphisms and associated phenotypes in the Arabidopsis relative Cardamine hirsuta . observed strong genetic differentiation among several ancestry groups broader distribution of Iberian relict strains European C compared to Arabidopsis. found synchronization between vegetative reproductive development a pervasive role for heterochronic pathways shaping variation. A single, fast-cycling ChFRIGIDA allele evolved adaptively allowing range expansion from glacial refugia,...
The evolution from outcrossing to selfing occurred recently across the eukaryote tree of life in plants, animals, fungi, and algae. Despite short-term advantages, is hypothetically an evolutionary dead-end reproductive strategy. tippy distribution on phylogenies suggests that most species are recent origin. However, dating such transitions challenging yet central for testing this hypothesis. We build previous theories disentangle differential effect past changes rate or population size...
Abstract Purifying selection is a critical factor in shaping genetic diversity. Current theoretical models mostly address scenarios of either very weak or strong selection, leaving significant gap our knowledge. The effects purifying on patterns genomic diversity remain poorly understood when against deleterious mutations to moderate, particularly recombination limited absent. In this study, we extend an existing approach, the fitness-class coalescent, incorporate arbitrary levels haploid...
Abstract Purifying selection is a critical factor in shaping genetic diversity. Current theoretical models only address scenarios of either very weak or strong selection, leaving significant gap our knowledge. The effects purifying on patterns genomic diversity remain poorly understood when against deleterious mutations to moderate, particularly recombination limited absent. In this study, we extend an existing approach, the fitness-class coalescent, incorporate arbitrary levels selection....