A5067422372- Environmental Toxicology and Ecotoxicology
- Heavy Metal Exposure and Toxicity
- Kruppel-like factors research
- Fish Ecology and Management Studies
- Animal Nutrition and Health
- Genetic Syndromes and Imprinting
- Pesticide and Herbicide Environmental Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Mercury impact and mitigation studies
- Arsenic contamination and mitigation
- Birth, Development, and Health
- Genomics, phytochemicals, and oxidative stress
- Toxic Organic Pollutants Impact
- Retinal Development and Disorders
- Fish Biology and Ecology Studies
- Organ Donation and Transplantation
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- Zebrafish Biomedical Research Applications
- Reproductive Biology and Fertility
- Chronic Kidney Disease and Diabetes
University of Maine
2019-2024
Chronic kidney disease of unknown etiology (CKDu) is an emerging global concern affecting several agricultural communities in the Americas and South Asia. Environmental contaminants such as heavy metals (e.g., Cd, As, Pb, V) organic pesticides glyphosate) drinking water have been hypothesized to play a role childhood onset progression this disease. However, comprehensive analysis chemical effects these compounds their mixtures on development function remains unknown. Here, we conducted...
Abstract Arsenic is a metalloid that contaminates drinking water supplies worldwide. Owing to concerns for human health, the World Health Organization and US Environmental Protection Agency have established safe level in of ≤10 ppb. Recently, arsenic exposure has also been linked lower IQ values children. The effect on neurogenesis, specifically eye development, not widely explored. This study aimed examine environmentally relevant concentrations early development by morphological molecular...
Abstract Contaminated drinking water is an important public health consideration in New England where well often found to contain arsenic and other metals such as cadmium, lead, uranium. Chronic or high level exposure these have been associated with multiple acute chronic diseases, including cancers impaired neurological development. While individual metal levels are regulated, adverse effects of mixtures, especially at concentrations considered safe for human consumption remain unclear....
Krüppel-like factor 9 (Klf9) is a feedforward regulator of glucocorticoid receptor (GR) signaling. Here we show that in zebrafish klf9 expressed with GR-dependent oscillatory dynamics synchrony fkbp5 , GR target encodes negative feedback We found transcript levels are elevated –/– mutants and Klf9 associates chromatin at the promoter, which becomes hyperacetylated –/ – mutants, suggesting regulates via an incoherent loop . As both Fkbp5 known to regulate metabolism, asked how loss affects...
Mixtures of chemical contaminants can pose a significant health risk to humans and wildlife, even at levels considered safe for each individual chemical. There is critical need develop statistical methods evaluate the drivers toxic effects in mixtures (i.e., bad actors) from exposure studies. Here, we hierarchical modeling framework disentangle toxicity complex metal screening study 92 drinking well water samples containing multiple elements Maine New Hampshire, USA. In order screen...
Agricultural run-off is complex mixture composed of low levels inorganic and organic pollutants known to contaminate drinking water sources around the globe. Metal mixtures, even at concentrations below maximum allowable limits (MALs), may elicit adverse biological impacts that depend on presence metal chelating compounds (e.g., herbicide glyphosate). As such, determining toxicity contamination from remains a challenge. Here we used zebrafish (Danio rerio) locomotor response light/dark...
Krüppel-like factor 9 (Klf9) is a feedforward regulator of glucocorticoid receptor (GR) signaling. We asked if klf9 interacts with fkbp5, negative feedback the GR implicated in stress-induced psychiatric and metabolic disorders. show that zebrafish fkbp5 are expressed highly correlated, GR-dependent oscillatory dynamics. Expression basally elevated klf9-/- mutants, Klf9 binds sequences promoter, suggesting an incoherent GR-fkbp5 circuit governs activity. Given both Fkbp5 regulate metabolism,...