A5056166395- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Historical Geopolitical and Social Dynamics
- Balkans: History, Politics, Society
- Platelet Disorders and Treatments
- Hungarian Social, Economic and Educational Studies
- Neural dynamics and brain function
- Multiple Sclerosis Research Studies
- Philippine History and Culture
- Inflammasome and immune disorders
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Sleep and related disorders
University of Szeged
2023-2024
Eötvös Loránd University
2000-2012
Novartis (Austria)
2007-2008
FTY720 [2-amino-2-[2-(4-octylphenyl) ethyl]propane-1,3-diol hydrochloride] is an oral sphingosine-1-phosphate receptor modulator under development for the treatment of multiple sclerosis (MS). The drug phosphorylated in vivo by sphingosine kinase 2 to its bioactive form, FTY720-P. Although with accompanied a reduction peripheral lymphocyte count, efficacy MS and experimental autoimmune encephalomyelitis (EAE) may be due additional, direct effects central nervous system (CNS). We now show...
FTY720 (fingolimod) is an oral sphingosine-1 phosphate (S1P) receptor modulator in phase III development for the treatment of multiple sclerosis. To further investigate its mode action, we analyzed gene expression central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE). downregulated inflammatory genes addition to vascular adhesion molecules. It decreased matrix metalloproteinase MMP-9 and increased counterregulator--tissue inhibitor metalloproteinase,...
The basal forebrain (BF) is a heterogeneous structure located in the ventral aspect of cerebral hemispheres. It contains cholinergic as well different types noncholinergic corticopetal neurons and interneurons, including GABAergic peptidergic cells. BF constitutes an extrathalamic route to cortex, its activity associated with increase cortical release neurotransmitter acetylcholine, concomitant electroencephalographic (EEG) low-voltage fast (LVFA). However, specific role cell has largely...
Orexin A and orexin B are neuropeptides produced by a group of neurons located in the lateral hypothalamus which send widespread projections virtually to whole neuraxis. Several studies indicated that orexins play crucial role sleep-wake regulation pathomechanism sleep disorder narcolepsy. As no data available related EEG effects healthy, freely moving rats, aim present experiments was analyze power changes generally used frequency bands after intracerebroventricular administration.Orexin...
The philosopher R. G. Collingwood claims in Idea of History that “every new generation must rewrite history its own way.”1 Revisiting and reframing given historical questions facilitates a more nuanced understanding the past. Apart from researching for sake, anniversaries different current actualities always make good excuse to reinvestigate certain phenomenon fresh angle. past couple years have been marked by centennial commemoration Great War 1914–1918, which left far-reaching impacts on...
Kaiga SAKIKO: Britain and the Intellectual Origins of League Nations, 1914–1919. Cambridge University Press, Cambridge, 2021. 224 p.
Reviewed by: The Balkans as Europe, 1821–1914 ed. by Timothy Snyder and Katherine Younger Balázs Balatoni (bio) (Eds.), (Rochester, NY: University of Rochester Press, 2018). 171 pp., ills. Index. ISBN: 978-1-58046-915-9. Over recent decades, historians the have engaged with different theoretical frameworks seeking to transcend limitations traditional national narratives frame their research transnational global contexts.1 This is also goal collection articles under review. book resulted from...