A5089958745- Organic Chemistry Cycloaddition Reactions
- Multicomponent Synthesis of Heterocycles
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Organic and Inorganic Chemical Reactions
- Inorganic and Organometallic Chemistry
- Crystallization and Solubility Studies
- Carbohydrate Chemistry and Synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Chemical Reaction Mechanisms
Ollscoil na Gaillimhe – University of Galway
2022-2024
The optimization of a multicomponent reaction, to prepare triarylpyridines (triphenylpyridine), and which includes 17 examples where each aryl substituent is distinct (non-symmetric pyridine) reported. non-symmetric triarylpyridine aqrar forming reaction involves the sequential addition two different acetophenones benzylamine in DMF presence copper (I) iodide (20 mol %), methanolic ammonia (2 equiv.), oxygen. optimized method was used give twenty five 43–91% yield, including products with...
Abstract The solvent‐free elimination of sulfinic acid and aromatization 1,6‐trans‐substituted bis(arylsulfone) trienes is reported. It shown that sublimation can be used as a ‘green’ method to combine the thermal transformation six crystal growth resulting 4‐(phenylsulfonyl)biphenyls. When conditions are carefully controlled, high quality single crystals 4‐(phenylsulfonyl)biphenyls obtained. Theoretical modelling reaction using simplified triene Ph‐(CH) 6 ‐SO 2 H showed cyclization...
1,6-trans-Substituted bis(arylsulfone) trienes undergo electrocyclization followed by elimination of phenylsulfinic acid, both in the gas phase, to give (4-phenylsulfonyl)biphenyls during sublimation. Pure, high-quality single crystals product grow desublimation area. More information can be found Research Article A. Erxleben and co-workers (DOI: 10.1002/chem.202400672).
The optimization of a multicomponent reaction, to prepare triphenylpyridines is reported. triphenylpyridine forming reaction involves the sequential addition two different acetophenones (or 2 equivalents one acetophenone) benzylamine in DMF presence copper (I) iodide (20 mol %), methanolic ammonia (2 equiv.), and oxygen. optimized method gave twenty 43-91% isolated yield includes 12 examples where three phenyl substituents are distinct (non-symmetric pyridine).